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Pterin is a representative derivative, and its analogs are widely used in biological systems. The two imine bonds within the pteridine ring confer electron donor\u2013acceptor properties, and the oxidized form exhibits fluorescence because of its \u03c0-conjugated system. Owing to these structural and electronic features, pterins perform a variety of physiological functions, including serving as cofactors, pigments, and signaling molecules. To date, studies ofin the dynamics of pterins have been conducted independently from chemical and biochemical perspectives; thus, the resulting knowledge has not been sufficiently systematized. This review provides a comprehensive overview of the dynamics of naturally occurring pterins by systematically integrating existing chemical and biochemical data.<\/jats:p>","DOI":"10.1093\/bbb\/zbag094","type":"journal-article","created":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T11:46:57Z","timestamp":1782388017000},"page":"1135-1146","source":"Crossref","is-referenced-by-count":0,"title":["Chemical and biological dynamics of natural pterins"],"prefix":"10.1093","volume":"90","author":[{"given":"Yuki","family":"Doi","sequence":"first","affiliation":[{"name":"Institute of Life and Environmental Sciences, University of Tsukuba , Tsukuba, Ibaraki ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,25]]},"reference":[{"key":"2026082503464403000_bib1","doi-asserted-by":"publisher","first-page":"4219","DOI":"10.1039\/JR9520004219","article-title":"812. Pteridine studies. Part III. 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