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After oral intake of siphonaxanthin in mice, siphonaxanthin and its dehydrometabolites were detected in plasma and skin-related tissues, with dehydrometabolites predominating. The metabolites modulated UVB-induced responses as well as siphonaxanthin itself, suggesting that the metabolic conversion does not abolish the activity.<\/jats:p>","DOI":"10.1093\/bbb\/zbag100","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T11:23:48Z","timestamp":1783337028000},"page":"1416-1419","source":"Crossref","is-referenced-by-count":0,"title":["Dehydrometabolites of siphonaxanthin predominate in skin tissues and retain biological activity in keratinocytes"],"prefix":"10.1093","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5663-0074","authenticated-orcid":false,"given":"Yuki","family":"Manabe","sequence":"first","affiliation":[{"name":"Division of Applied Biosciences, Graduate School of Agriculture, Kyoto University , Kyoto ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natsuki","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Division of Applied Biosciences, 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