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Anti-inflammatory effects and restoration of uncoupling protein-1 (UCP-1) expression were observed in both models, indicating that the macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression.<\/jats:p>","DOI":"10.1093\/bbb\/zbag133","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:04:59Z","timestamp":1788264299000},"source":"Crossref","is-referenced-by-count":0,"title":["A macrophage-conditioned medium model recapitulates inflammation-associated suppression of UCP-1 expression in KK-Ay mice"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1941-3342","authenticated-orcid":false,"given":"Hisako","family":"Takahashi","sequence":"first","affiliation":[{"name":"Department of Agricultural Chemistry, School of Agriculture, Meiji University , Kanagawa ,","place":["Japan"]},{"name":"Department of Nutritional Science and Food Safety, Faculty of Applied Bioscience, Tokyo University of 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