{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T12:51:15Z","timestamp":1791636675273,"version":"4.3.4"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:00:00Z","timestamp":1791590400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Raspberry ketone was identified as a contributor to the sweet, fruity flavor of heated Taoerxing Pushan Yezi (TPY) tobacco (Nicotiana tabacum L.) leaves through comparisons with an authentic standard, exploratory gas chromatography-olfactometry (GC-O), and descriptive sensory evaluation of spiked samples. Adding 2.0\u00a0mg\/kg to a Japanese cultivar lacking berry-like aroma elicited qualitative comments on body (flavor richness and fullness), mellowness, softness, and reduced irritation. TDU-GC-MS\/MS, which heats leaf samples in the inlet unit, detected 2\u20139\u00a0ppm in TPY leaves. Most importantly, amylase and protease treatments increased free raspberry ketone. LC-MS\/MS, without sample heating during measurement, quantified 0.6\u00a0mg\/kg in the control, versus 2.8, 5.4, and 9.0\u00a0mg\/kg after amylase, protease, and \u03b2-glucosidase treatments, respectively. These results suggest that free raspberry ketone may be retained within a matrix containing starch, proteins, and polyphenolic glycosides, or that raspberry ketone occurs as glycosides, and that it is released upon heating during smoking.<\/jats:p>","DOI":"10.1093\/bbb\/zbag153","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T11:53:27Z","timestamp":1791546807000},"source":"Crossref","is-referenced-by-count":0,"title":["Raspberry Ketone as a Contributor to the Sweet, Fruity Flavor of Heated Tobacco (\n                    <i>Nicotiana tabacum<\/i>\n                    L.) Leaves and Insights into Its Occurrence Form"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4556-0709","authenticated-orcid":false,"given":"Toru","family":"Kishimoto","sequence":"first","affiliation":[{"name":"Leaf Tobacco Research Center , Japan Tobacco Inc., 1900 Idei, Oyama, Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuka","family":"Koizumi","sequence":"additional","affiliation":[{"name":"Leaf Tobacco Research Center , Japan Tobacco Inc., 1900 Idei, Oyama, Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kei","family":"Bando","sequence":"additional","affiliation":[{"name":"Leaf Tobacco Research Center , Japan Tobacco Inc., 1900 Idei, Oyama, Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuta","family":"Negishi","sequence":"additional","affiliation":[{"name":"Leaf Tobacco Research Center , Japan Tobacco Inc., 1900 Idei, Oyama, Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taishi","family":"Hirase","sequence":"additional","affiliation":[{"name":"Leaf Tobacco Research Center , Japan Tobacco Inc., 1900 Idei, Oyama, Tochigi ,","place":["Japan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,10]]},"container-title":["Bioscience, Biotechnology, and Biochemistry"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article-pdf\/doi\/10.1093\/bbb\/zbag153\/71836852\/zbag153.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article-pdf\/doi\/10.1093\/bbb\/zbag153\/71836852\/zbag153.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T11:54:11Z","timestamp":1791633251000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bbb\/advance-article\/doi\/10.1093\/bbb\/zbag153\/8907182"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,10]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1093\/bbb\/zbag153","relation":{},"ISSN":["1347-6947"],"issn-type":[{"value":"1347-6947","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,10]]},"article-number":"zbag153"}}