{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T21:10:03Z","timestamp":1785186603798,"version":"3.55.0"},"reference-count":137,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T00:00:00Z","timestamp":1661385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["33\/10\/2019-TF\/Rare\/BMS"],"award-info":[{"award-number":["33\/10\/2019-TF\/Rare\/BMS"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,4,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Activin A receptor type I (ACVR1), a transmembrane serine\/threonine kinase, belongs to the transforming growth factor-\u03b2 superfamily, which signals via phosphorylating the downstream effectors and SMAD transcription factors. Its central role in several biological processes and intracellular signaling is well known. Genetic variation in ACVR1 has been associated with a rare disease, fibrodysplasia ossificans progressive, and its somatic alteration is reported in rare cancer diffuse intrinsic pontine glioma. Furthermore, altered expression or variation of ACVR1 is associated with multiple pathologies such as polycystic ovary syndrome, congenital heart defects, diffuse idiopathic skeletal hyperostosis, posterior fossa ependymoma and other malignancies. Recent advancements have witnessed ACVR1 as a potential pharmacological target, and divergent promising approaches for its therapeutic targeting have been explored. This review highlights the structural and functional characteristics of receptor ACVR1, associated signaling pathways, genetic variants in several diseases and cancers, protein\u2013protein interaction, gene expression, regulatory miRNA prediction and potential therapeutic targeting approaches. The comprehensive knowledge will offer new horizons and insights into future strategies harnessing its therapeutic potential.<\/jats:p>","DOI":"10.1093\/bfgp\/elac026","type":"journal-article","created":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T06:07:56Z","timestamp":1661407676000},"page":"123-142","source":"Crossref","is-referenced-by-count":7,"title":["Multi-omics therapeutic perspective on ACVR1 gene: from genetic alterations to potential targeting"],"prefix":"10.1093","volume":"22","author":[{"given":"Garima","family":"Nagar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pooja","family":"Mittal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shradheya R 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Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,8,25]]},"reference":[{"key":"2023041318221912100_","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.cytogfr.2020.09.003","article-title":"Receptor binding competition: a paradigm for regulating TGF-\u03b2 family action","volume":"57","author":"Martinez-Hackert","year":"2021","journal-title":"Cytokine Growth Factor Rev"},{"key":"2023041318221912100_","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nrendo.2016.12","article-title":"BMP signalling in skeletal development, disease and repair","volume":"12","author":"Salazar","year":"2016","journal-title":"Nat Rev Endocrinol"},{"key":"2023041318221912100_","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021899","article-title":"Bone morphogenetic proteins","volume":"8","author":"Katagiri","year":"2016","journal-title":"Cold Spring 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