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Passing through different mechanisms, non-coding RNAs (ncRNAs) play a pivotal role in NDDs through various mechanisms, by changing the expression of some genes, interference with protein translation and alterations in some signaling pathways. It urges the need to introduce novel strategies and therapeutic agents with multi-targeting potentials. Phytochemicals are hopeful antioxidants and anti-inflammatory agents with promising modulatory roles on dysregulated signaling pathways and protein translation during NDDs. In this study, the role of ncRNAs (e.g. lncRNAs, miRNA, siRNAs and piRNAs) was highlighted in NDDs. This study also aimed to investigate the role of phytochemicals (phenolic compounds, alkaloids, terpenoids and sulfur compounds) in the modulation of ncRNAs during NDDs such as Alzheimer's disease, Parkinson's disease, epilepsy, depression and amyotrophic lateral sclerosis.<\/jats:p>","DOI":"10.1093\/bfgp\/elac055","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T17:31:59Z","timestamp":1671125519000},"page":"143-160","source":"Crossref","is-referenced-by-count":11,"title":["The regulatory role of non-coding RNAs and their interactions with phytochemicals in neurodegenerative diseases: a systematic review"],"prefix":"10.1093","volume":"22","author":[{"given":"Sajad","family":"Fakhri","sequence":"first","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences , Kermanshah 6734667149, 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