{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:36:13Z","timestamp":1791282973120,"version":"4.1.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2023,6,3]],"date-time":"2023-06-03T00:00:00Z","timestamp":1685750400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Heilongjiang Postdoctoral Fund","award":["LBH-Z20158"],"award-info":[{"award-number":["LBH-Z20158"]}]},{"name":"Applied Technology Research and Development Project of Heilongjiang","award":["GA20C018"],"award-info":[{"award-number":["GA20C018"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62102120"],"award-info":[{"award-number":["62102120"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["61972116"],"award-info":[{"award-number":["61972116"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["U20A20376"],"award-info":[{"award-number":["U20A20376"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,3,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Abnormalities of DNA modifications are closely related to the pathogenesis and prognosis of pancreatic cancer. The development of third-generation sequencing technology has brought opportunities for the study of new epigenetic modification in cancer. Here, we screened the N6-methyladenine (6mA) and 5-methylcytosine (5mC) modification in pancreatic cancer based on Oxford Nanopore Technologies sequencing. The 6mA levels were lower compared with 5mC and upregulated in pancreatic cancer. We developed a novel method to define differentially methylated deficient region (DMDR), which overlapped 1319 protein-coding genes in pancreatic cancer. Genes screened by DMDRs were more significantly enriched in the cancer genes compared with the traditional differential methylation method (P\u2009&amp;lt;\u20090.001 versus P =\u20090.21, hypergeometric test). We then identified a survival-related signature based on DMDRs (DMDRSig) that stratified patients into high- and low-risk groups. Functional enrichment analysis indicated that 891 genes were closely related to alternative splicing. Multi-omics data from the cancer genome atlas showed that these genes were frequently altered in cancer samples. Survival analysis indicated that seven genes with high expression (ADAM9, ADAM10, EPS8, FAM83A, FAM111B, LAMA3 and TES) were significantly associated with poor prognosis. In addition, the distinction for pancreatic cancer subtypes was determined using 46 subtype-specific genes and unsupervised clustering. Overall, our study is the first to explore the molecular characteristics of 6mA modifications in pancreatic cancer, indicating that 6mA has the potential to be a target for future clinical treatment.<\/jats:p>","DOI":"10.1093\/bfgp\/elad021","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T13:27:04Z","timestamp":1686317224000},"page":"150-162","source":"Crossref","is-referenced-by-count":6,"title":["Functional characteristics of DNA N6-methyladenine modification based on long-read sequencing in pancreatic cancer"],"prefix":"10.1093","volume":"23","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9205-4641","authenticated-orcid":false,"given":"Dianshuang","family":"Zhou","sequence":"first","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Second Military Medical University (Naval Medical University) Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, , Shanghai 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyun","family":"Zhao","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Honghao","family":"Liu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feiyang","family":"Zhou","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2039-7167","authenticated-orcid":false,"given":"Yan","family":"Huang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Gu","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Jin","sequence":"additional","affiliation":[{"name":"Second Military Medical University (Naval Medical University) Department of Hepatobiliary Pancreatic Surgery, Changhai Hospital, , Shanghai 200433 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-2484","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Harbin Institute of Technology School of Life Science and Technology, Computational Biology Research Center, , Harbin 150006 , China"},{"name":"Guangzhou Medical University State Key Laboratory of Respiratory Disease, , Guangzhou , China"},{"name":"Qiqihar Medical University College of Pathology, , Qiqihar 161042 , 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