{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T17:20:39Z","timestamp":1740158439331,"version":"3.37.3"},"reference-count":160,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T00:00:00Z","timestamp":1714435200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFA1102800"],"award-info":[{"award-number":["2021YFA1102800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92249304","82301746"],"award-info":[{"award-number":["92249304","82301746"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science Foundation for Distinguished Young Scholars of Guangdong Province","award":["2019B151502008"],"award-info":[{"award-number":["2019B151502008"]}]},{"name":"Hangzhou Youth Innovation Team Project","award":["TD2023020"],"award-info":[{"award-number":["TD2023020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,9,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As the demographic structure shifts towards an aging society, strategies aimed at slowing down or reversing the aging process become increasingly essential. Aging is a major predisposing factor for many chronic diseases in humans. The hematopoietic system, comprising blood cells and their associated bone marrow microenvironment, intricately participates in hematopoiesis, coagulation, immune regulation and other physiological phenomena. The aging process triggers various alterations within the hematopoietic system, serving as a spectrum of risk factors for hematopoietic disorders, including clonal hematopoiesis, immune senescence, myeloproliferative neoplasms and leukemia. The emerging single-cell technologies provide novel insights into age-related changes in the hematopoietic system. In this review, we summarize recent studies dissecting hematopoietic system aging using single-cell technologies. We discuss cellular changes occurring during aging in the hematopoietic system at the levels of the genomics, transcriptomics, epigenomics, proteomics, metabolomics and spatial multi-omics. Finally, we contemplate the future prospects of single-cell technologies, emphasizing the impact they may bring to the field of hematopoietic system aging research.<\/jats:p>","DOI":"10.1093\/bfgp\/elae019","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T01:49:00Z","timestamp":1714528140000},"page":"639-650","source":"Crossref","is-referenced-by-count":1,"title":["Unveiling aging dynamics in the hematopoietic system insights from single-cell technologies"],"prefix":"10.1093","volume":"23","author":[{"given":"Xinrong","family":"Jin","sequence":"first","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruohan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunqi","family":"Fu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiunan","family":"Zhu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liquan","family":"Hong","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aiwei","family":"Wu","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's Hospital of Deqing, Deqing Hospital of Hangzhou Normal University, Hangzhou Normal University , Hangzhou 311121,","place":["China"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hu","family":"Wang","sequence":"additional","affiliation":[{"name":"Zhejiang Key Laboratory of Medical Epigenetics, School of Basic Medical Sciences, The Third People's 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