{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T12:59:57Z","timestamp":1790600397561,"version":"4.1.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T00:00:00Z","timestamp":1790553600000},"content-version":"vor","delay-in-days":270,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006087","name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico-Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN-206326"],"award-info":[{"award-number":["IN-206326"]}],"id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030583","name":"Secretar\u00eda de Ciencia, Humanidades, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["4067674"],"award-info":[{"award-number":["4067674"]}],"id":[{"id":"10.13039\/100030583","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Promoters are DNA sequences responsible for the specific recognition of the transcriptional machinery in all the biological systems. In bacteria, two main groups of promoters have been described, the \u03c370-like family, which includes the housekeeping \u03c370 and the alternative \u03c338, \u03c332, \u03c328, and \u03c324; and the \u03c354 family. However, promoter sequences may differ even inside the same family, and this classification may not fully capture the functional diversity of groups. In this work, we explored and classified a collection of bacterial promoters associated with six \u03c3 factor families in the bacterium Escherichia coli K-12 using a Supervised clustering workflow that uses Shapley values. From this analysis, we identified two subgroups of sequences differentiated by the conservation of the \u22129 to \u22127 positions upstream the Transcription Start Site, suggesting that this region may be employed in classification frameworks. Finally, a detailed analysis of \u03c370 promoter sequences identify five clusters with a conserved signal in the \u221210, but with different sequence composition. In summary, these signatures could provide more insights into the sigma factor-promoter interaction and the separation of the DNA double-strand.<\/jats:p>","DOI":"10.1093\/bfgp\/elag008","type":"journal-article","created":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T11:19:59Z","timestamp":1786965599000},"source":"Crossref","is-referenced-by-count":0,"title":["Supervised clustering of bacterial promoter identifies two groups with different relevant positions at \u221210"],"prefix":"10.1093","volume":"25","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8176-1980","authenticated-orcid":false,"given":"Paulo","family":"Cambranis-Boldo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Matem\u00e1ticas Aplicadas y en Sistemas, Unidad Acad\u00e9mica del Estado de Yucat\u00e1n, Universidad Nacional Aut\u00f3noma de M\u00e9xico , M\u00e9rida, Yucat\u00e1n , 97302,","place":["M\u00e9xico"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7656-0579","authenticated-orcid":false,"given":"Gustavo Sganzerla","family":"Martinez","sequence":"additional","affiliation":[{"name":"Microbiology and Immunology, Dalhousie University , 5850 College Street, Halifax, Nova Scotia, B3H4H7 ,","place":["Canada"]},{"name":"Department of Basic Medical Sciences, Shantou University Medical College , Shantou, 515041, Guangdong ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4699-0199","authenticated-orcid":false,"given":"Andr\u00e9 Borges","family":"Farias","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio Nacional de Computa\u00e7\u00e3o Cient\u00edfica - LNCC , , Petr\u00f3polis, Rio de Janeiro 25651075 ,","place":["Brazil"]},{"name":"Avenida Get\u00falio Vargas , , Petr\u00f3polis, Rio de Janeiro 25651075 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