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Eliminating MAP\u2013the etiopathological agent might be a better strategy to treat MAP-associated autoimmune diseases. In this case study, we conducted a systematic in silico analysis to identify the metabolic chokepoints of MAP\u2019s mimicry proteins and their interacting partners. The probable inhibitors of chokepoint proteins were identified using DrugBank. DrugBank molecules were stringently screened and molecular interactions were analyzed by molecular docking and \u2018off-target\u2019 binding. Thus, we identified 18 metabolic chokepoints of MAP mimicry proteins and 13 DrugBank molecules that could inhibit three chokepoint proteins viz. katG, rpoB and narH. On the basis of molecular interaction between drug and target proteins finally eight DrugBank molecules, viz. DB00609, DB00951, DB00615, DB01220, DB08638, DB08226, DB08266 and DB07349 were selected and are proposed for treatment of three MAP-associated autoimmune diseases namely, T1DM, CD and multiple sclerosis. Because these molecules are either approved by the Food and Drug Administration or these are experimental drugs that can be easily incorporated in clinical studies or tested in vitro. The proposed strategy may be used to repurpose drugs to treat autoimmune diseases induced by other pathogens.<\/jats:p>","DOI":"10.1093\/bib\/bbaa195","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T11:17:22Z","timestamp":1596194242000},"source":"Crossref","is-referenced-by-count":7,"title":["Discerning novel drug targets for treating <i>Mycobacterium avium ss. paratuberculosis<\/i>-associated autoimmune disorders: an <i>in silico<\/i> approach"],"prefix":"10.1093","volume":"22","author":[{"given":"Anjali","family":"Garg","sequence":"first","affiliation":[{"name":"University of Delhi South Campus, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelja","family":"Singhal","sequence":"additional","affiliation":[{"name":"University of Delhi South Campus, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7936-9892","authenticated-orcid":false,"given":"Manish","family":"Kumar","sequence":"additional","affiliation":[{"name":"University of Delhi South Campus, New Delhi"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"2021052110394946300_ref1","doi-asserted-by":"crossref","first-page":"4057","DOI":"10.1128\/JCM.00904-10","article-title":"Efficient differentiation of Mycobacterium avium complex species and subspecies by use of five-target multiplex PCR","volume":"48","author":"Shin","year":"2010","journal-title":"J Clin Microbiol"},{"key":"2021052110394946300_ref2","first-page":"96","article-title":"Mycobacterium avium ss. 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