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Its variabilities are attributed to multiple regulators, including the key factor of genetic variants. To comprehensively investigate the potentials of neurodegenerative disease-susceptibility variants from the view of A-to-I RNA editing, we analyzed matched genetic and transcriptomic data of 1596 samples across nine brain tissues and whole blood from two large consortiums, Accelerating Medicines Partnership-Alzheimer\u2019s Disease and Parkinson\u2019s Progression Markers Initiative. The large-scale and genome-wide identification of 95\u00a0198 RNA editing quantitative trait loci revealed the preferred genetic effects on adjacent editing events. Furthermore, to explore the underlying mechanisms of the genetic controls of A-to-I RNA editing, several top RNA-binding proteins were pointed out, such as EIF4A3, U2AF2, NOP58, FBL, NOP56 and DHX9, since their regulations on multiple RNA-editing events were probably interfered by these genetic variants. Moreover, these variants may also contribute to the variability of other molecular phenotypes associated with RNA editing, including the functions of 3 proteins, expressions of 277 genes and splicing of 449 events. All the analyses results shown in NeuroEdQTL (https:\/\/relab.xidian.edu.cn\/NeuroEdQTL\/) constituted a unique resource for the understanding of neurodegenerative pathogenesis from genotypes to phenotypes related to A-to-I RNA editing.<\/jats:p>","DOI":"10.1093\/bib\/bbad007","type":"journal-article","created":{"date-parts":[[2023,1,2]],"date-time":"2023-01-02T08:09:09Z","timestamp":1672646949000},"source":"Crossref","is-referenced-by-count":10,"title":["Genetic control of RNA editing in neurodegenerative disease"],"prefix":"10.1093","volume":"24","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2863-6065","authenticated-orcid":false,"given":"Sijia","family":"Wu","sequence":"first","affiliation":[{"name":"Xidian University School of Life Science and Technology, , Xi\u2019an 710071 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuping","family":"Xue","sequence":"additional","affiliation":[{"name":"Xidian University School of Life Science and Technology, , Xi\u2019an 710071 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5235-5733","authenticated-orcid":false,"given":"Mengyuan","family":"Yang","sequence":"additional","affiliation":[{"name":"Zhengzhou University School of Life Sciences, , Zhengzhou 450001 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Wang","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston Center for Computational Systems Medicine, School of Biomedical Informatics, , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8321-6864","authenticated-orcid":false,"given":"Pora","family":"Kim","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston Center for Computational Systems Medicine, School of Biomedical Informatics, , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobo","family":"Zhou","sequence":"additional","affiliation":[{"name":"The University of Texas Health Science Center at Houston Center for Computational Systems Medicine, School of Biomedical Informatics, , Houston, Texas 77030 , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6534-2712","authenticated-orcid":false,"given":"Liyu","family":"Huang","sequence":"additional","affiliation":[{"name":"Xidian University School of Life Science and Technology, , Xi\u2019an 710071 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,1,21]]},"reference":[{"key":"2023080810533745900_ref1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.tig.2015.12.005","article-title":"RNA editing: a contributor to neuronal dynamics in the mammalian 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