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These approaches are typically conducted independently and focus on one protein at a time, overlooking nucleotide substitutions outside of coding regions or mutational co-occurrences in genes within the same interaction network. Here, we present CancerHubs, a method that integrates unbiased mutational data, clinical outcome predictions and interactomics to define novel cancer-related protein hubs. Through this approach, we identified TGOLN2 as a putative novel broad cancer tumour suppressor and EFTUD2 as a putative novel multiple myeloma oncogene.<\/jats:p>","DOI":"10.1093\/bib\/bbae635","type":"journal-article","created":{"date-parts":[[2024,12,10]],"date-time":"2024-12-10T23:18:41Z","timestamp":1733872721000},"source":"Crossref","is-referenced-by-count":2,"title":["CancerHubs: a systematic data mining and elaboration approach for identifying novel cancer-related protein interaction hubs"],"prefix":"10.1093","volume":"26","author":[{"given":"Ivan","family":"Ferrari","sequence":"first","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi , Milan ,","place":["Italy"]},{"name":"Department of Biosciences, University of Milan , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Federica","family":"De Grossi","sequence":"additional","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi , Milan ,","place":["Italy"]},{"name":"Department of Biosciences, University of Milan , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giancarlo","family":"Lai","sequence":"additional","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi , Milan ,","place":["Italy"]},{"name":"Department of Biosciences, University of Milan , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Oliveto","sequence":"additional","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica Invernizzi , Milan ,","place":["Italy"]},{"name":"Department of Biosciences, University of Milan , Milan ,","place":["Italy"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giorgia","family":"Deroma","sequence":"additional","affiliation":[{"name":"INGM, Istituto Nazionale Genetica Molecolare Romeo ed Enrica 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