{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:12:50Z","timestamp":1790856770013,"version":"4.1.0"},"reference-count":126,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":46,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Multimodal data integration approaches represent a breakthrough advancement in artificial intelligence applications for rheumatoid arthritis (RA) research, enabling comprehensive analysis of heterogeneous, high-dimensional datasets spanning genomics, transcriptomics, proteomics, medical imaging and longitudinal electronic health records (EHRs). This comprehensive review systematically examines the development and application of computational fusion strategies in RA\u2014early, late and intermediate fusion, as well as graph-based integration\u2014across key tasks including early diagnosis, disease activity quantification, treatment response prediction, patient stratification and drug repurposing. We highlight the distinctive capabilities of these frameworks in end-to-end representation learning, cross-modal knowledge transfer and interpretable decision support. Furthermore, we thoroughly discuss major challenges\u2014data heterogeneity and harmonization, structured missingness, model interpretability, computational scalability and reproducibility\u2014and explore emerging solutions such as adaptive fusion architectures, federated and privacy-preserving learning, self-supervised pretraining and model compression. In conclusion, this paper aims to objectively evaluate the current landscape of multimodal computational methods in RA, delineate their advantages and limitations, and offer strategic recommendations to guide future research toward clinically translatable precision rheumatology.<\/jats:p>","DOI":"10.1093\/bib\/bbag073","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T12:40:53Z","timestamp":1769776853000},"source":"Crossref","is-referenced-by-count":6,"title":["Computational approaches to multimodal data integration in rheumatoid arthritis: from data landscape to clinical translation"],"prefix":"10.1093","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1957-5762","authenticated-orcid":false,"given":"Deren","family":"Xu","sequence":"first","affiliation":[{"name":"Jinhua Research Institute, Zhejiang Chinese Medical University, Zhejiang University Netcom Technology Industrial Incubation Park , Jindong District, Jinhua City, Zhejiang Province 321000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujun","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Medicine Rheumatology, Zhejiang Province College of Basic Medical Sciences, Zhejiang Chinese Medical University Hangzhou , Zhejiang 310053 ,","place":["China"]},{"name":"Jinhua Academy Zhejiang Chinese Medical University Jinhua, Zhejiang 321000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Luo","sequence":"additional","affiliation":[{"name":"City University of Macau Av. Padre Tom\u00e1s Pereira Taipa Macau , SAR 999078 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengping","family":"Wen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Chinese Medicine Rheumatology, Zhejiang Province, College of Basic Medical Sciences, Zhejiang Chinese Medical University , Zheda Netcom Technology Industrial Incubation Park \u2013 Zhejiang Central Laboratory, Tangya Town, Jindong District, Jinhua, Zhejiang 321000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,2,16]]},"reference":[{"key":"2026021523270662700_ref1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1007\/s11926-023-01129-2","article-title":"Synovial tissue insights into heterogeneity of rheumatoid arthritis","volume":"26","author":"Jonsson","year":"2023","journal-title":"Curr Rheumatol 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