{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T06:47:46Z","timestamp":1791960466183,"version":"4.3.4"},"reference-count":84,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T00:00:00Z","timestamp":1791936000000},"content-version":"vor","delay-in-days":43,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>High-throughput biotechnologies have significantly advanced precision medicine by enabling the exploitation of global gene expression patterns to enhance our understanding of disease etiology, progression, and treatment options. However, the tissue-specific nature of gene expression presents a challenge, particularly for less accessible tissues such as the brain, underscoring the need for computational methods to accurately impute gene expression in these critical but hard-to-reach tissues. While several attempts to impute gene expression in tissue-specific contexts have shown promising results, their reliance on regression analysis faces limitations due to the inability to capture complex, nonlinear relationships in gene expression patterns. In contrast, modern machine learning techniques, particularly graph neural networks, have demonstrated superior performance by efficiently modeling the intricate interactions among genes across different tissues. Therefore, we introduce gene expression imputation with graph attention networks (gemGAT), a novel approach leveraging GATs to enhance gene expression prediction across different tissues. gemGAT distinguishes itself by predicting the expression of all genes simultaneously, utilizing the full spectrum of genomic data to account for gene coexpressions and nonlinear relationships. Validated through extensive experiments with Genotype-Tissue Expression data and a case study from the Alzheimer\u2019s Disease Neuroimaging Initiative, gemGAT demonstrates superior performance over existing methods by efficiently capturing nonlinear gene coexpressions. This advancement underscores gemGAT\u2019s potential to significantly contribute to precision medicine, showcasing its utility in advancing our understanding of gene expression in less accessible tissues.<\/jats:p>","DOI":"10.1093\/bib\/bbag557","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T11:26:55Z","timestamp":1790335615000},"source":"Crossref","is-referenced-by-count":0,"title":["Cross-tissue graph attention networks for semi-supervised gene expression prediction"],"prefix":"10.1093","volume":"27","author":[{"given":"Shiyu","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Emory University , 1518 Clifton Rd NE, Atlanta, GA 30322, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianxing","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Computer Science, Emory University , 400 Dowman Drive, Atlanta, GA 30322 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Bioinformatics, Emory University , 1518 Clifton Rd NE, Atlanta, GA 30322, \u00a0","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muran","family":"Qin","sequence":"additional","affiliation":[{"name":"Computer Science & Engineering Department, University of California San Diego , 9500 Gilman Drive, La Jolla, CA 92093 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijuan","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, School of Public Health and Beijing International Center for Mathematical Research, Peking University , No. 5 Yiheyuan Road, Haidian District, Beijing 100871 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