{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:33:54Z","timestamp":1772138034029,"version":"3.50.1"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":113,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["HG011052"],"award-info":[{"award-number":["HG011052"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","award":["HG011052-03S1"],"award-info":[{"award-number":["HG011052-03S1"]}],"id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["T32 HL007567"],"award-info":[{"award-number":["T32 HL007567"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Nearly two decades of genome-wide association studies (GWAS) have identify thousands of disease-associated genetic variants, but very few genes with evidence of causality. Recent methodological advances demonstrate that Mendelian randomization (MR) using expression quantitative loci (eQTLs) as instrumental variables can detect potential causal genes. However, existing MR approaches are not well suited to handle the complexity of eQTL GWAS data structure and so they are subject to bias, inflation, and incorrect inference.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We present a whole-genome regulatory network analysis tool (HORNET), which is a comprehensive set of statistical and computational tools to perform genome-wide searches for causal genes using summary level GWAS data, i.e. robust to biases from multiple sources. Applying HORNET to schizophrenia, eQTL effects in the cerebellum were spread throughout the genome, and in the cortex were more localized to select loci.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Freely available at https:\/\/github.com\/noahlorinczcomi\/HORNET or Mac, Windows, and Linux users.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbaf068","type":"journal-article","created":{"date-parts":[[2025,4,17]],"date-time":"2025-04-17T05:37:57Z","timestamp":1744868277000},"source":"Crossref","is-referenced-by-count":1,"title":["HORNET: tools to find genes with causal evidence and their regulatory networks using eQTLs"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0517-2499","authenticated-orcid":false,"given":"Noah","family":"Lorincz-Comi","sequence":"first","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6563-3579","authenticated-orcid":false,"given":"Yihe","family":"Yang","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayakrishnan","family":"Ajayakumar","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Makaela","family":"Mews","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valentina","family":"Bermudez","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Neurosciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9729-6519","authenticated-orcid":false,"given":"William","family":"Bush","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0037-411X","authenticated-orcid":false,"given":"Xiaofeng","family":"Zhu","sequence":"additional","affiliation":[{"name":"Case Western Reserve University Department of Population and Quantitative Health Sciences , Cleveland, OH 44106,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"2025061901542392500_vbaf068-B1","first-page":"1","article-title":"Meta-analysis of GWAS of over 16,000 individuals with autism spectrum disorder highlights a novel locus at 10q24.32 and a significant overlap with schizophrenia","volume":"8","author":"Anney","year":"2017","journal-title":"Mol Autism"},{"key":"2025061901542392500_vbaf068-B2","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1002\/gepi.21989","article-title":"A perspective on interaction effects in genetic association studies","volume":"40","author":"Aschard","year":"2016","journal-title":"Genet Epidemiol"},{"key":"2025061901542392500_vbaf068-B3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1214\/ss\/1032280304","article-title":"Bioequivalence trials, intersection-union tests and equivalence confidence sets","volume":"11","author":"Berger","year":"1996","journal-title":"Stat Sci"},{"key":"2025061901542392500_vbaf068-B4","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1214\/009053607000000758","article-title":"Regularized estimation of large covariance matrices","volume":"36","author":"Bickel","year":"2008","journal-title":"Ann Stat"},{"key":"2025061901542392500_vbaf068-B5","author":"Burgess","year":"2015"},{"key":"2025061901542392500_vbaf068-B6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1002\/gepi.22077","article-title":"Mendelian randomization with fine-mapped genetic data: choosing from large numbers of correlated instrumental variables","volume":"41","author":"Burgess","year":"2017","journal-title":"Genet Epidemiol"},{"key":"2025061901542392500_vbaf068-B7","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.biopsych.2020.09.016","article-title":"Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus","volume":"89","author":"Chang","year":"2021","journal-title":"Biol Psychiatry"},{"key":"2025061901542392500_vbaf068-B8","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1016\/j.cell.2020.06.045","article-title":"Trans-ethnic and ancestry-specific blood-cell genetics in 746,667 individuals from 5 global populations","volume":"182","author":"Chen","year":"2020","journal-title":"Cell"},{"key":"2025061901542392500_vbaf068-B9","doi-asserted-by":"crossref","first-page":"6490","DOI":"10.1038\/s41467-022-34164-1","article-title":"Mendelian randomization accounting for complex correlated horizontal pleiotropy while elucidating shared genetic etiology","volume":"13","author":"Cheng","year":"2022","journal-title":"Nat Commun"},{"key":"2025061901542392500_vbaf068-B10","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.jmva.2018.12.002","article-title":"Fixed support positive-definite modification of covariance matrix estimators via linear shrinkage","volume":"171","author":"Choi","year":"2019","journal-title":"J Multivar Anal"},{"key":"2025061901542392500_vbaf068-B11","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/s41467-023-36862-w","article-title":"OTTERS: a powerful TWAS framework leveraging summary-level reference data","volume":"14","author":"Dai","year":"2023","journal-title":"Nat Commun"},{"key":"2025061901542392500_vbaf068-B12","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/s41562-024-02091-4","article-title":"Gene-level analysis reveals the genetic aetiology and therapeutic targets of schizophrenia","volume":"9","author":"Dang","year":"2025","journal-title":"Nat Hum Behav"},{"key":"2025061901542392500_vbaf068-B13","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/s41588-023-01300-6","article-title":"Brain expression quantitative trait locus and network analyses reveal downstream effects and putative drivers for brain-related diseases","volume":"55","author":"de Klein","year":"2023","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B14","doi-asserted-by":"crossref","first-page":"3470","DOI":"10.1093\/bioinformatics\/bty354","article-title":"JRmGRN: joint reconstruction of multiple gene regulatory networks with common hub genes using data from multiple tissues or conditions","volume":"34","author":"Deng","year":"2018","journal-title":"Bioinformatics"},{"key":"2025061901542392500_vbaf068-B15","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1159\/000446581","article-title":"Accuracy of gene scores when pruning markers by linkage disequilibrium","volume":"80","author":"Dudbridge","year":"2015","journal-title":"Hum Hered"},{"key":"2025061901542392500_vbaf068-B16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fcell.2014.00038","article-title":"Gene regulatory networks and their applications: understanding biological and medical problems in terms of networks","volume":"2","author":"Emmert-Streib","year":"2014","journal-title":"Front Cell Dev Biol"},{"key":"2025061901542392500_vbaf068-B17","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1198\/016214501753382273","article-title":"Variable selection via nonconcave penalized likelihood and its oracle properties","volume":"96","author":"Fan","year":"2001","journal-title":"J Am Stat Assoc"},{"key":"2025061901542392500_vbaf068-B18","doi-asserted-by":"crossref","first-page":"16","DOI":"10.12688\/wellcomeopenres.16544.1","article-title":"Mendelian randomization for studying the effects of perturbing drug targets","volume":"6","author":"Gill","year":"2021","journal-title":"Wellcome Open Res"},{"key":"2025061901542392500_vbaf068-B19","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/gepi.22506","article-title":"Statistical methods for cis-Mendelian randomization with two-sample summary-level data","volume":"47","author":"Gkatzionis","year":"2023","journal-title":"Genet Epidemiol"},{"key":"2025061901542392500_vbaf068-B20","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1002\/gepi.22380","article-title":"A robust two-sample transcriptome-wide Mendelian randomization method integrating GWAS with multi-tissue eQTL summary statistics","volume":"45","author":"Gleason","year":"2021","journal-title":"Genet Epidemiol"},{"key":"2025061901542392500_vbaf068-B21","doi-asserted-by":"crossref","first-page":"10584","DOI":"10.1073\/pnas.1000274107","article-title":"Strong synaptic transmission impact by copy number variations in schizophrenia","volume":"107","author":"Glessner","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025061901542392500_vbaf068-B22","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1002\/ajmg.b.32349","article-title":"Genome-wide association study of schizophrenia in Ashkenazi Jews","volume":"168","author":"Goes","year":"2015","journal-title":"Am J Med Genet B Neuropsychiatr Genet"},{"key":"2025061901542392500_vbaf068-B23","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1126\/science.1262110","article-title":"The genotype-tissue expression (GTEx) pilot analysis: multitissue gene regulation in humans","volume":"348","author":"GTEx Consortium","year":"2015","journal-title":"Science"},{"key":"2025061901542392500_vbaf068-B24","first-page":"3367","article-title":"Matrix completion and low-rank SVD via fast alternating least squares","volume":"16","author":"Hastie","year":"2015","journal-title":"J Mach Learn Res"},{"key":"2025061901542392500_vbaf068-B25","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jeconom.2021.07.010","article-title":"Smoothed quantile regression with large-scale inference","volume":"232","author":"He","year":"2023","journal-title":"J Econom"},{"key":"2025061901542392500_vbaf068-B26","doi-asserted-by":"crossref","first-page":"i206","DOI":"10.1093\/bioinformatics\/btv240","article-title":"Identification of causal genes for complex traits","volume":"31","author":"Hormozdiari","year":"2015","journal-title":"Bioinformatics"},{"key":"2025061901542392500_vbaf068-B27","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1093\/schbul\/sby140","article-title":"Genome-wide association study detected novel susceptibility genes for schizophrenia and shared trans-populations\/diseases genetic effect","volume":"45","author":"Ikeda","year":"2019","journal-title":"Schizophr Bull"},{"key":"2025061901542392500_vbaf068-B28","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.ajhg.2022.04.004","article-title":"Powerful and robust inference of complex phenotypes\u2019 causal genes with dependent expression quantitative loci by a median-based Mendelian randomization","volume":"109","author":"Jiang","year":"2022","journal-title":"Am J Hum Genet"},{"key":"2025061901542392500_vbaf068-B29","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/nrm2503","article-title":"Modelling and analysis of gene regulatory networks","volume":"9","author":"Karlebach","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025061901542392500_vbaf068-B30","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1056\/NEJM200009073431006","article-title":"The HLA system","volume":"343","author":"Klein","year":"2000","journal-title":"N Engl J Med"},{"key":"2025061901542392500_vbaf068-B31","doi-asserted-by":"crossref","first-page":"104811","DOI":"10.1016\/j.nbd.2020.104811","article-title":"Alzheimer\u2019s disease pathology in APOE transgenic mouse models: the who, what, when, where, why, and how","volume":"139","author":"Lewandowski","year":"2020","journal-title":"Neurobiol Dis"},{"key":"2025061901542392500_vbaf068-B32","first-page":"10","article-title":"On the problem of inflation in transcriptome-wide association studies","volume":"2023","author":"Liang","year":"2023","journal-title":"bioRxiv"},{"key":"2025061901542392500_vbaf068-B33","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/j.ajhg.2023.02.014","article-title":"Robust multivariable Mendelian randomization based on constrained maximum likelihood","volume":"110","author":"Lin","year":"2023","journal-title":"Am J Hum Genet"},{"key":"2025061901542392500_vbaf068-B34","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fpsyt.2020.00256","article-title":"Integrated analysis of summary statistics to identify pleiotropic genes and pathways for the comorbidity of schizophrenia and cardiometabolic disease","volume":"11","author":"Liu","year":"2020","journal-title":"Front Psychiatry"},{"key":"2025061901542392500_vbaf068-B35","doi-asserted-by":"crossref","first-page":"3141","DOI":"10.1038\/s41380-024-02574-w","article-title":"Integration of multi-omics summary data reveals the role of N6-methyladenosine in neuropsychiatric disorders","volume":"29","author":"Liufu","year":"2024","journal-title":"Mol Psychiatry"},{"key":"2025061901542392500_vbaf068-B36","first-page":"5080346","article-title":"Combining xQTL and genome-wide association studies from ethnically diverse populations improves druggable gene discovery","author":"Lorincz-Comi","year":"2025","journal-title":"SSRN"},{"key":"2025061901542392500_vbaf068-B37","first-page":"100290","article-title":"MRBEE: a bias-corrected multivariable Mendelian randomization method","volume":"5","author":"Lorincz-Comi","year":"2024","journal-title":"HGG Adv"},{"key":"2025061901542392500_vbaf068-B38","first-page":"2287","article-title":"Spectral regularization algorithms for learning large incomplete matrices","volume":"11","author":"Mazumder","year":"2010","journal-title":"J Mach Learn Res"},{"key":"2025061901542392500_vbaf068-B39","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/s41588-020-0631-4","article-title":"Mendelian randomization accounting for correlated and uncorrelated pleiotropic effects using genome-wide summary statistics","volume":"52","author":"Morrison","year":"2020","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B40","volume-title":"Multivariate Statistical Analysis","author":"Mukhopadhyay","year":"2009"},{"key":"2025061901542392500_vbaf068-B41","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1002\/gepi.21953","article-title":"JAM: a scalable Bayesian framework for joint analysis of marginal SNP effects","volume":"40","author":"Newcombe","year":"2016","journal-title":"Genet Epidemiol"},{"key":"2025061901542392500_vbaf068-B42","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrg3908","article-title":"Genetic linkage analysis in the age of whole-genome sequencing","volume":"16","author":"Ott","year":"2015","journal-title":"Nat Rev Genet"},{"key":"2025061901542392500_vbaf068-B43","doi-asserted-by":"crossref","first-page":"20160290","DOI":"10.1098\/rstb.2016.0290","article-title":"The INO80 remodeller in transcription, replication, and repair","volume":"372","author":"Poli","year":"2017","journal-title":"Philos Trans R Soc B Biol Sci"},{"key":"2025061901542392500_vbaf068-B44","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1038\/s41467-019-10936-0","article-title":"Mendelian randomization integrating GWAS and eQTL data reveals genetic determinants of complex and clinical traits","volume":"10","author":"Porcu","year":"2019","journal-title":"Nat Commun"},{"key":"2025061901542392500_vbaf068-B45","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1086\/519795","article-title":"PLINK: a tool set for whole-genome association and population-based linkage analyses","volume":"81","author":"Purcell","year":"2007","journal-title":"Am J Hum Genet"},{"key":"2025061901542392500_vbaf068-B46","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1464-5491.2005.01499.x","article-title":"Animal models of diabetes mellitus","volume":"22","author":"Rees","year":"2005","journal-title":"Diabet Med"},{"key":"2025061901542392500_vbaf068-B47","doi-asserted-by":"crossref","first-page":"e1007371","DOI":"10.1371\/journal.pgen.1007371","article-title":"Evaluation and application of summary statistic imputation to discover new height-associated loci","volume":"14","author":"Rueger","year":"2018","journal-title":"PLoS Genet"},{"key":"2025061901542392500_vbaf068-B48","doi-asserted-by":"crossref","first-page":"a038984","DOI":"10.1101\/cshperspect.a038984","article-title":"Multivariable Mendelian randomization and mediation","volume":"11","author":"Sanderson","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025061901542392500_vbaf068-B49","doi-asserted-by":"crossref","first-page":"3255","DOI":"10.1038\/s41467-020-16969-0","article-title":"Genetic drug target validation using Mendelian randomisation","volume":"11","author":"Schmidt","year":"2020","journal-title":"Nat Commun"},{"key":"2025061901542392500_vbaf068-B50","doi-asserted-by":"crossref","first-page":"D977","DOI":"10.1093\/nar\/gkac1010","article-title":"The NHGRI-EBI GWAS catalog: knowledgebase and deposition resource","volume":"51","author":"Sollis","year":"2023","journal-title":"Nucleic Acids Res"},{"key":"2025061901542392500_vbaf068-B51","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1038\/ng.940","article-title":"Genome-wide association study identifies five new schizophrenia loci","volume":"43","author":"SPGWAS Consortium","year":"2011","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B52","doi-asserted-by":"crossref","first-page":"e1001779","DOI":"10.1371\/journal.pmed.1001779","article-title":"UK Biobank: an open access resource for identifying the causes of a wide range of complex diseases of middle and old age","volume":"12","author":"Sudlow","year":"2015","journal-title":"PLoS Med"},{"key":"2025061901542392500_vbaf068-B53","doi-asserted-by":"crossref","first-page":"eabn2937","DOI":"10.1126\/science.abn2937","article-title":"Leveraging base-pair mammalian constraint to understand genetic variation and human disease","volume":"380","author":"Sullivan","year":"2023","journal-title":"Science"},{"key":"2025061901542392500_vbaf068-B54","first-page":"1","article-title":"Introducing human APOE into A\u03b2 transgenic mouse models","volume":"1","author":"Tai","year":"2011","journal-title":"Int J Alzheimer\u2019s Dis"},{"key":"2025061901542392500_vbaf068-B55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"The 1000 Genomes Project Consortium","year":"2015","journal-title":"Nature"},{"key":"2025061901542392500_vbaf068-B56","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/s41586-022-04434-5","article-title":"Mapping genomic loci implicates genes and synaptic biology in schizophrenia","volume":"604","author":"Trubetskoy","year":"2022","journal-title":"Nature"},{"key":"2025061901542392500_vbaf068-B57","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s42003-022-03031-6","article-title":"Cross-tissue transcriptome-wide association studies identify susceptibility genes shared between schizophrenia and inflammatory bowel disease","volume":"5","author":"Uellendahl-Werth","year":"2022","journal-title":"Commun Biol"},{"key":"2025061901542392500_vbaf068-B58","doi-asserted-by":"crossref","first-page":"4930","DOI":"10.1038\/s41467-020-18716-x","article-title":"Mendelian randomization while jointly modeling cis genetics identifies causal relationships between gene expression and lipids","volume":"11","author":"Van Der Graaf","year":"2020","journal-title":"Nat Commun"},{"key":"2025061901542392500_vbaf068-B59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s13059-016-1131-9","article-title":"Controlling bias and inflation in epigenome- and transcriptome-wide association studies using the empirical null distribution","volume":"18","author":"van Iterson","year":"2017","journal-title":"Genome Biol"},{"key":"2025061901542392500_vbaf068-B60","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from Mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B61","author":"Vosa","year":"2018"},{"key":"2025061901542392500_vbaf068-B62","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1038\/s41588-021-00913-z","article-title":"Large-scale cis- and trans-eQTL analyses identify thousands of genetic loci and polygenic scores that regulate blood gene expression","volume":"53","author":"Vosa","year":"2021","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B63","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/s41588-020-0637-y","article-title":"Discovery of 318 new risk loci for type 2 diabetes and related vascular outcomes among 1.4 million participants in a multi-ancestry meta-analysis","volume":"52","author":"Vujkovic","year":"2020","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B64","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng.2213","article-title":"Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits","volume":"44","author":"Yang","year":"2012","journal-title":"Nat Genet"},{"key":"2025061901542392500_vbaf068-B65","doi-asserted-by":"crossref","first-page":"ujae148","DOI":"10.1093\/biomtc\/ujae148","article-title":"Estimation of a genetic Gaussian network using GWAS summary data","volume":"80","author":"Yang","year":"2024","journal-title":"Biometrics"},{"key":"2025061901542392500_vbaf068-B66","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s12859-017-1576-1","article-title":"Enhanced construction of gene regulatory networks using hub gene information","volume":"18","author":"Yu","year":"2017","journal-title":"BMC Bioinformatics"},{"key":"2025061901542392500_vbaf068-B67","first-page":"894","article-title":"Nearly unbiased variable selection under minimax concave penalty","volume-title":"Ann Statist","author":"Zhang","year":"2010"},{"key":"2025061901542392500_vbaf068-B68","doi-asserted-by":"crossref","first-page":"e1009455","DOI":"10.1371\/journal.pgen.1009455","article-title":"MRLocus: identifying causal genes mediating a trait through Bayesian estimation of allelic heterogeneity","volume":"17","author":"Zhu","year":"2021","journal-title":"PLoS Genet"},{"key":"2025061901542392500_vbaf068-B69","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajhg.2014.11.011","article-title":"Meta-analysis of correlated traits via summary statistics from GWAS with an application in hypertension","volume":"96","author":"Zhu","year":"2015","journal-title":"Am J Hum Genet"},{"key":"2025061901542392500_vbaf068-B70","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1093\/bioinformatics\/btaa985","article-title":"An iterative approach to detect pleiotropy and perform Mendelian randomization analysis using GWAS summary statistics","volume":"37","author":"Zhu","year":"2021","journal-title":"Bioinformatics"}],"container-title":["Bioinformatics Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformaticsadvances\/advance-article-pdf\/doi\/10.1093\/bioadv\/vbaf068\/62953146\/vbaf068.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformaticsadvances\/article-pdf\/5\/1\/vbaf068\/62953146\/vbaf068.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformaticsadvances\/article-pdf\/5\/1\/vbaf068\/62953146\/vbaf068.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,19]],"date-time":"2025-06-19T01:54:36Z","timestamp":1750298076000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformaticsadvances\/article\/doi\/10.1093\/bioadv\/vbaf068\/8115995"}},"subtitle":[],"editor":[{"given":"Anna-Sophie","family":"Fiston-Lavier","sequence":"additional","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2024,12,26]]},"references-count":70,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,12,26]]}},"URL":"https:\/\/doi.org\/10.1093\/bioadv\/vbaf068","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.10.28.24316273","asserted-by":"object"}]},"ISSN":["2635-0041"],"issn-type":[{"value":"2635-0041","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025]]},"published":{"date-parts":[[2024,12,26]]},"article-number":"vbaf068"}}