{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T06:09:14Z","timestamp":1779343754503,"version":"3.51.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T00:00:00Z","timestamp":1761350400000},"content-version":"vor","delay-in-days":303,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Vicerrector\u00eda de Investigaci\u00f3n y Doctorados de la Universidad San Sebasti\u00e1n\u2014Fondo"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>CTCF is a conserved protein involved in the establishment and maintenance of topologically associating domains (TADs) and loops. Alzheimer\u2019s disease (AD) represents the most common form of dementia, affecting over 50 million elderly individuals. Epigenetic alterations are a hallmark of AD, and epigenetic disruptions are able to affect CTCF binding and looping. Understanding the dynamics of CTCF loops behind AD may lead to new, undiscovered contributions of CTCF to the etiology of AD. To understand the dynamics behind CTCF loops, we developed a CTCF loop predictor using different genomic and epigenomic features, such as CTCF motif information, CTCF protein binding information, and different histone marks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We obtained F-scores of over 0.9 in GM12878 and K562 cell lines. We reported the importance of each feature in classification, and compared the results with other loop predictors. After testing the predictor, we predicted loops in control and AD data, reported a score of loop disruption and selected the top disrupted loops on AD which were all previously linked with AD in bibliography. Our study contributes to a better understanding of the role of CTCF binding and CTCF loops in gene regulation, and highlights new clues about CTCF in the etiology and development of AD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The method can be found in https:\/\/github.com\/networkbiolab\/jalpy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbaf268","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T12:27:22Z","timestamp":1761222442000},"source":"Crossref","is-referenced-by-count":0,"title":["Gaining insights into Alzheimer\u2019s disease by predicting chromatin spatial organization"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7157-3872","authenticated-orcid":false,"given":"Camilo","family":"Villaman","sequence":"first","affiliation":[{"name":"Fundaci\u00f3n Ciencia & Vida Laboratorio de Redes Biol\u00f3gicas, , Avenida del Valle Norte 725, Huechuraba , Santiago, 8580702,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cartas-Espinel","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica de Temuco Laboratorio de Investigaci\u00f3n en Salud de Precisi\u00f3n, Departamento de Procesos Diagn\u00f3sticos y Evaluaci\u00f3n, Facultad de Ciencias de la Salud, , Manuel Montt 56 , Temuco, 4813302,","place":["Chile"]},{"name":"Universidad Cat\u00f3lica de Temuco Centro de Investigaci\u00f3n, Innovaci\u00f3n y Creaci\u00f3n UCT, , Rudecindo Ortega 03694 , Temuco, 4781509,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Saez","sequence":"additional","affiliation":[{"name":"Universidad Cat\u00f3lica de Temuco Laboratorio de Investigaci\u00f3n en Salud de Precisi\u00f3n, Departamento de Procesos Diagn\u00f3sticos y Evaluaci\u00f3n, Facultad de Ciencias de la Salud, , Manuel Montt 56 , Temuco, 4813302,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto J M","family":"Martin","sequence":"additional","affiliation":[{"name":"Fundaci\u00f3n Ciencia & Vida Laboratorio de Redes Biol\u00f3gicas, , Avenida del Valle Norte 725, Huechuraba , Santiago, 8580702,","place":["Chile"]},{"name":"Universidad San Sebasti\u00e1n Escuela de Ingenier\u00eda, Facultad de Ingenier\u00eda, , Bellavista 7, Recoleta , Santiago, 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