{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:19:30Z","timestamp":1777987170692,"version":"3.51.4"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:00:00Z","timestamp":1767916800000},"content-version":"vor","delay-in-days":8,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>Since the emergence of SARS-CoV-2, numerous studies have investigated antibody interactions with viral variants in vitro, and several datasets have been curated to compile available protein structures and experimental measurements. However, existing data remain fragmented, limiting their utility for the development and validation of machine learning models for antibody\u2013antigen interaction prediction. Here, we present CoV-UniBind, a unified database comprising over 75\u00a0000 entries of SARS-CoV-2 antibody\u2013antigen sequence, binding, and structural data, integrated and standardized from three public sources and multiple peer-reviewed publications. To demonstrate its utility, we benchmarked multiple protein folding, inverse folding, and language models across tasks relevant to antibody design and vaccine development. We expect CoV-UniBind to facilitate future computational efforts in antibody and vaccine development against SARS-CoV-2.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The curated datasets, model scores and antibody synonyms are free to download at https:\/\/huggingface.co\/datasets\/InstaDeepAI\/cov-unibind. Folded structures are available upon request.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbaf328","type":"journal-article","created":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T12:39:44Z","timestamp":1767789584000},"source":"Crossref","is-referenced-by-count":0,"title":["CoV-UniBind: a unified antibody binding database for SARS-CoV-2"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-2795-806X","authenticated-orcid":false,"given":"Aryan","family":"Bhasin","sequence":"first","affiliation":[{"name":"InstaDeep Ltd Applied AI, , London, W2 1AY,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6444-4952","authenticated-orcid":false,"given":"Francesco","family":"Saccon","sequence":"additional","affiliation":[{"name":"InstaDeep Ltd Applied AI, , London, W2 1AY,","place":["United 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C","family":"Walls","sequence":"additional","affiliation":[{"name":"BioNTech US Systems Immunology, , Cambridge, MA 02139,","place":["United States"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1184-7421","authenticated-orcid":false,"given":"Yunguan","family":"Fu","sequence":"additional","affiliation":[{"name":"InstaDeep Ltd Applied AI, , London, W2 1AY,","place":["United Kingdom"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,8]]},"reference":[{"key":"2026050508240951000_vbaf328-B1","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1006\/jmbi.1997.1354","article-title":"Standard conformations for the canonical structures of immunoglobulins","volume":"273","author":"Al-Lazikani","year":"1997","journal-title":"J Mol 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