{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T13:19:10Z","timestamp":1777987150804,"version":"3.51.4"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":26,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Secretaria de Ciencia, Humanidades, Tecnolog\u00eda e Inovaci\u00f3n","award":["PDCPN2015-1518"],"award-info":[{"award-number":["PDCPN2015-1518"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico-PAPIIT-UNAM","award":["IN202125"],"award-info":[{"award-number":["IN202125"]}]},{"name":"Direcci\u00f3n General de Asuntos del Personal Acad\u00e9mico-PAPIIT-UNAM","award":["IN208422"],"award-info":[{"award-number":["IN208422"]}]},{"name":"Secretaria de Ciencia"},{"name":"Humanidades"},{"name":"Tecnolog\u00eda e Inovaci\u00f3n","award":["836888"],"award-info":[{"award-number":["836888"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Dysregulation of Ca2+-signaling genes has been shown in some types of cancer; however, it is virtually unknown in hepatitis B-derived hepatocellular carcinoma (HBV-HCC). Here, we evaluate the transcriptional and epigenetic regulation of Ca2+-signaling genes in HBV-HCC and whether their expression is associated with cancer hallmarks, and prognostic potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 432 differentially expressed Ca2+-signaling genes in HBV-HCC, including 134 that are specific to this condition, and were not found in non-HBV HCC. Fifty-three of these genes were associated with cancer hallmarks, of which 17 exhibited potential prognostic value by Cox multivariate analyses. We also provide new evidence for epigenetic regulation by post-transcriptional histone modifications and DNA methylation at the promoter of some of these genes. Finally, using Least Absolute Shrinkage and Selection Operator (LASSO) regression, we identified a four-gene prognostic signature (FBLN1, STC2, C1R, and F2RL2) that robustly stratified patient outcomes. This study presents the first integrative transcriptomic and epigenetic analysis of Ca2+-signaling genes in HBV-HCC, introducing a novel four-gene signature with prognostic potential. These findings highlight the relevance of a dysregulation of a subset of Ca2+-signaling genes as a distinctive feature of HBV-HCC.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>All data generated or analyzed during this study are included in this article.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbaf331","type":"journal-article","created":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T12:43:50Z","timestamp":1769172230000},"source":"Crossref","is-referenced-by-count":0,"title":["Transcriptional and epigenetic regulation of Ca2+-signaling genes in hepatitis B-derived hepatocellular carcinoma and their association with the cancer hallmarks"],"prefix":"10.1093","volume":"6","author":[{"given":"Guadalupe","family":"Hern\u00e1ndez-Mart\u00ednez","sequence":"first","affiliation":[{"name":"Programa de Doctorado en Ciencias de la Salud, Universidad Veracruzana , Xalapa, Veracruz 91190, M\u00e9xico"},{"name":"Laboratorio de Biolog\u00eda Molecular, Instituto de Investigaciones Biol\u00f3gicas, Universidad Veracruzana , Xalapa, Veracruz 91190, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andr\u00e9s","family":"Hern\u00e1ndez-Oliveras","sequence":"additional","affiliation":[{"name":"Centro Cient\u00edfico y Tecnol\u00f3gico de Excelencia Ciencia & Vida, Fundaci\u00f3n Ciencia & Vida , Santiago 8580702,","place":["Chile"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00c1ngel","family":"Zarain-Herzberg","sequence":"additional","affiliation":[{"name":"Departamento de Bioqu\u00edmica, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico , CDMX 04360, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1737-0270","authenticated-orcid":false,"given":"Juan","family":"Santiago-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Laboratorio de Biolog\u00eda Molecular, Instituto de Investigaciones Biol\u00f3gicas, Universidad Veracruzana , Xalapa, Veracruz 91190, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2026,1,27]]},"reference":[{"key":"2026050508245247600_vbaf331-B1","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1159\/000512277","article-title":"The role of calcium signaling in regulation of epithelial-mesenchymal transition","volume":"211","author":"Adiga","year":"2022","journal-title":"Cells Tissues Organs"},{"key":"2026050508245247600_vbaf331-B2","doi-asserted-by":"crossref","first-page":"W537","DOI":"10.1093\/nar\/gky379","article-title":"The Galaxy platform for accessible, 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