{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T17:06:17Z","timestamp":1784567177622,"version":"3.55.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":195,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AI Driven Development and Validation of Disease Prediction and Detection Methods"},{"name":"BCSIR R&D","award":["BCSIR R&D 2024-25 DLAB-42"],"award-info":[{"award-number":["BCSIR R&D 2024-25 DLAB-42"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>The Motivation: Long non-coding RNAs (lncRNAs) are important regulators of gene expression and are increasingly implicated in cancer. However, the extent to which aberrant DNA methylation is associated with lncRNA dysregulation in lung adenocarcinoma (LUAD) remains underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>By integrating RNA-seq and Illumina 450K methylation data from 473 LUAD and 32 normal lung samples in TCGA, we identified 2,668 differentially expressed lncRNAs and 20,843 differentially methylated CpG sites. Mapping CpGs to lncRNA promoters (\u22121.5\u2009kb from the annotated TSS) and Spearman correlation analysis highlighted seven lncRNAs with inverse promoter methylation\u2013expression patterns; FAM83A-AS2 and AC012213.1 showed the most consistent associations and were linked to poorer overall survival in Kaplan\u2013Meier and Cox models (adjusted for age, sex, and tumor stage). A two-lncRNA prognostic score derived using LASSO Cox regression showed moderate time-dependent discrimination at 590\u2009days (AUC\u2009=\u20090.72) within the TCGA cohort. An exploratory lncRNA\u2013miRNA\u2013mRNA network suggested miRNA-mediated regulation of LUAD genes, with enrichment analyses linking targets to chromatin modification and epigenetic regulation. These findings nominate FAM83A-AS2 and AC012213.1 as candidate epigenetically associated prognostic lncRNAs in LUAD, warranting validation in independent cohorts and functional studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbag096","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T12:23:26Z","timestamp":1777638206000},"source":"Crossref","is-referenced-by-count":0,"title":["Integrative multi-omics analysis identifies methylation-associated lncRNAs FAM83A-AS2 and AC012213.1 as candidate prognostic markers in lung adenocarcinoma"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9497-5380","authenticated-orcid":false,"given":"Syed Muktadir","family":"Al Sium","sequence":"first","affiliation":[{"name":"Bangladesh Council of Scientific and Industrial Research , Dhaka, 1205,","place":["Bangladesh"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahafujul Islam 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