{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T10:35:22Z","timestamp":1786444522396,"version":"build-2736575974"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T00:00:00Z","timestamp":1783728000000},"content-version":"vor","delay-in-days":191,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81973518"],"award-info":[{"award-number":["81973518"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Cervical cancer remains a major global health challenge, particularly in low-resource settings where treatment efficacy is limited by drug resistance and toxicity. Although Panax notoginseng (Sanqi) has demonstrated anticancer activity, its molecular mechanisms against cervical cancer remain insufficiently understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>An integrated transcriptomic and systems pharmacology approach was employed to investigate the therapeutic mechanisms of Panax notoginseng in cervical cancer. Transcriptomic analysis identified 533 overlapping differentially expressed genes associated with cell cycle regulation, DNA replication, cellular senescence, and p53 signaling. Network pharmacology revealed 291 overlapping targets between P. notoginseng compounds and cervical cancer-related genes. Protein\u2013protein interaction analysis identified tumor necrosis factor, interleukin-6, proto-oncogene, non-receptor tyrosine kinase (SRC), TOP2A, and CDC45 as key hub genes involved in inflammation, apoptosis, and tumor progression. Molecular docking demonstrated strong binding affinities of ginsenoside Re, Panaxadiol, Daucosterol, and Stigmasterol toward core targets, while molecular dynamics simulations confirmed stable protein\u2013ligand interactions. Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) analysis suggested comparable pharmacokinetic properties and low predicted toxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The datasets analyzed in this study are publicly available through the Gene Expression Omnibus database under accession numbers GSE63514 and GSE9750. Additional data supporting the findings of this study are available within the article and its Supplementary Materials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbag164","type":"journal-article","created":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T08:59:30Z","timestamp":1783760370000},"source":"Crossref","is-referenced-by-count":0,"title":["Exploring the molecular basis of\n                    <i>Panax notoginseng<\/i>\n                    mediated inhibition of cervical cancer through machine learning, transcriptomics analysis, network pharmacology, molecular docking, and in-silico simulation approaches"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9218-2929","authenticated-orcid":false,"given":"Shah","family":"Kamal","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine, Faculty of Medicine, Yangzhou University , Yangzhou, Jiangsu 225009,","place":["PR China"]},{"name":"Key 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Jiangsu 225009,","place":["PR China"]},{"name":"Key Laboratory of the Jiangsu Higher Education Institutions for Integrated Traditional Chinese and Western Medicine, Senile Diseases Control (Yangzhou University) , Yangzhou, Jiangsu 225009,","place":["PR China"]},{"name":"Sino-Malaysia Molecular Oncology and Traditional Chinese Medicine Delivery Joint Research Centre, Medical College, Yangzhou University , Yangzhou, Jiangsu 225009,","place":["PR China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Amjad Kamal","sequence":"additional","affiliation":[{"name":"Future Technologies Research Centre, King Faisal University , PO Box 400, Al Ahsa 31982,","place":["Saudi Arabia"]},{"name":"Department of Health Sciences, Novel Global Community Educational Foundation, Hebersham, NSW 2770 ,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenji","family":"Li","sequence":"additional","affiliation":[{"name":"School of 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