{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:03:07Z","timestamp":1792785787927,"version":"4.5.0"},"reference-count":31,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":267,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"New York University Langone Hospital\u2013Long Island","id":[{"id":"https:\/\/ror.org\/0190ak572","id-type":"ROR","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK112971"],"award-info":[{"award-number":["R01DK112971"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK135630"],"award-info":[{"award-number":["R01DK135630"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK132056"],"award-info":[{"award-number":["R01DK132056"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,7]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Ferroptosis is an iron-dependent regulated cell death process involving lipid peroxidation, redox imbalance, and impaired antioxidant defense. It is increasingly relevant to metabolic liver disease and non-alcoholic steatohepatitis. Existing ferroptosis resources mainly provide gene annotations and disease associations, but they do not offer an integrated workflow for user-uploaded transcriptome data, liver-focused enrichment, dataset-level scoring, and ferroptosis-senescence cross-talk analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We developed FerroEnrich, an open-source web platform for analyzing ferroptosis and senescence programs in human and mouse liver transcriptome datasets. FerroEnrich supports count matrix upload, metadata-guided differential expression analysis, identification of ferroptosis-prone and ferroptosis-resistant genes, dataset-level ferroptosis index scoring, sample-level susceptibility estimation, curated liver module enrichment, interaction network visualization, and ferroptosis-senescence cross-talk analysis. Application to human advanced non-alcoholic steatohepatitis and mouse diet-induced liver disease datasets demonstrated cross-species utility and identified conserved remodeling, including reduced ferroptosis-protective signatures and increased senescence- and fibrosis-associated modules.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>FerroEnrich is freely available at https:\/\/ferroenrich.shinyapps.io\/ferroenrich\/. Source code, documentation, and demo datasets are available at the FerroEnrich GitHub repository.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioadv\/vbag285","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:22:20Z","timestamp":1790310140000},"source":"Crossref","is-referenced-by-count":0,"title":["FerroEnrich: an interactive web platform for liver-focused ferroptosis index scoring, enrichment, and ferroptosis\u2013senescence cross-talk analysis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0177-7925","authenticated-orcid":false,"given":"Munichandra Babu","family":"Tirumalasetty","sequence":"first","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine , Mineola, NY,","place":["United 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University Grossman Long Island School of Medicine , Mineola, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5915-8935","authenticated-orcid":false,"given":"Wahiduzzaman","family":"Md","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine , Mineola, NY,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3125-1238","authenticated-orcid":false,"given":"Qing Robert","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Foundations of Medicine, New York University Grossman Long Island School of Medicine , Mineola, NY,","place":["United 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