{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T18:16:23Z","timestamp":1787940983985,"version":"build-2784847793"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,8,10]],"date-time":"2026-08-10T00:00:00Z","timestamp":1786320000000},"content-version":"vor","delay-in-days":9,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIH\/NCI CCSG","award":["P30 CA016059"],"award-info":[{"award-number":["P30 CA016059"]}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HL158796"],"award-info":[{"award-number":["R01 HL158796"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH\/NCI CCSG","award":["P30 CA016672"],"award-info":[{"award-number":["P30 CA016672"]}]},{"name":"Andrew Sabin Family Fellowship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>The gut microbiome shapes cancer therapy response through its influence on host metabolism. While prior studies examine pairwise associations between individual genera and metabolites, there is limited methodology for identifying microbial genera that systematically regulate the overall metabolome. Scalable statistical tools are needed to uncover such system-level \u201cmaster predictors\u201d in high-dimensional microbiome-metabolome data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We introduce B-MASTER, a scalable Bayesian multivariate regression framework combining \u21131 sparsity and \u21132 group shrinkage to identify essential cross-metabolite regulators. A Gibbs sampler enables near-linear computational scaling, supporting models with millions of parameters. The method is supported by theoretical guarantees, including posterior contraction and selection consistency. Analysis of colorectal cancer microbiome-metabolome data reveals key microbial genera that govern global and cancer-associated metabolite patterns, highlighting system-level regulatory structure.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>The B-MASTER code, including demonstration scripts, is available at https:\/\/github.com\/priyamdas2\/B-MASTER. An archived snapshot of the code corresponding to this manuscript is available on Zenodo with DOI: 10.5281\/zenodo.20484958.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag500","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T11:54:26Z","timestamp":1786190066000},"source":"Crossref","is-referenced-by-count":0,"title":["B-MASTER: scalable Bayesian multivariate regression for master predictor discovery in colorectal cancer microbiome-metabolite profiles"],"prefix":"10.1093","volume":"42","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2384-0486","authenticated-orcid":false,"given":"Priyam","family":"Das","sequence":"first","affiliation":[{"name":"Department of Biostatistics, Virginia Commonwealth University , Richmond, VA 23219,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5559-211X","authenticated-orcid":false,"given":"Tanujit","family":"Dey","sequence":"additional","affiliation":[{"name":"Center for Surgery and Public Health, Brigham and Women\u2019s Hospital, Harvard Medical School , Boston, MA 02115,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3316-0468","authenticated-orcid":false,"given":"Christine B","family":"Peterson","sequence":"additional","affiliation":[{"name":"Department of Statistics, Rice University , Houston, TX 77005,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2022-1735","authenticated-orcid":false,"given":"Sounak","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Missouri , Columbia, MI 65211,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,10]]},"reference":[{"key":"2026082813192554700_btag500-B1","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/j.2517-6161.1982.tb01195.x","article-title":"The statistical analysis of compositional data","volume":"44","author":"Aitchison","year":"1982","journal-title":"J R Stat Soc"},{"key":"2026082813192554700_btag500-B2","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cell.2014.03.011","article-title":"Role of the microbiota in immunity and inflammation","volume":"157","author":"Belkaid","year":"2014","journal-title":"Cell"},{"key":"2026082813192554700_btag500-B3","doi-asserted-by":"crossref","first-page":"4516","DOI":"10.1073\/pnas.1000080107","article-title":"Global patterns of 16s rrna diversity at a depth of millions of sequences per sample","volume":"108","author":"Caporaso","year":"2011","journal-title":"Proc Natl Acad Sci"},{"key":"2026082813192554700_btag500-B4","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1093\/biomet\/asz056","article-title":"Bayesian sparse multiple regression for simultaneous rank reduction and variable selection","volume":"107","author":"Chakraborty","year":"2020","journal-title":"Biometrika"},{"key":"2026082813192554700_btag500-B5","doi-asserted-by":"crossref","first-page":"4370","DOI":"10.1158\/1078-0432.CCR-21-1129","article-title":"Facts and hopes for gut microbiota interventions in cancer immunotherapy","volume":"28","author":"Davar","year":"2022","journal-title":"Clin Cancer Res"},{"key":"2026082813192554700_btag500-B6","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1080\/10618600.2019.1593179","article-title":"Simultaneous variable and covariance selection with the multivariate spike-and-slab lasso","volume":"28","author":"Deshpande","year":"2019","journal-title":"J. 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