{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:07:44Z","timestamp":1788908864741,"version":"build-2803163510"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T00:00:00Z","timestamp":1787788800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science and Technology Council, Taiwan","award":["NSTC 114\u20132221-E-A49-143-"],"award-info":[{"award-number":["NSTC 114\u20132221-E-A49-143-"]}]},{"name":"National Science and Technology Council, Taiwan","award":["114\u20132740-B-400\u2013005-"],"award-info":[{"award-number":["114\u20132740-B-400\u2013005-"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Motivation<\/jats:title>\n                    <jats:p>Prioritizing therapeutic targets from high-dimensional transcriptomic profiles is hindered by the underdetermined nature of the p\u2002\u226b \u00a0n setting. While miRNA signatures can inform target prioritization, conventional accuracy-driven methods may yield unstable predictive signatures, reducing downstream network reliability and topology-guided candidate ranking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We propose TargetPrior, a stability-aware evolutionary learning framework in which EL-CAML derives reproducible miRNA anchors from relapse-associated transcriptomic variation for candidate target prioritization. In childhood acute myeloid leukemia (CAML), EL-CAML identifies a parsimonious 18-miRNA continuous relapse-risk signature and 10 complementary stability-supported biomarkers, yielding 28 miRNAs for literature-curated miRNA\u2013gene network construction. Repeated perturbation analysis supported the stability of high-frequency miRNAs, while analysis of the independent GSE196886 cell-sorted small RNA-seq dataset identified cell-population-specific expression differences. Benchmarking against an expanded set of clinically and biologically supported AML target references showed stronger early-rank retrieval than network-only and statistical approaches. TargetPrior is presented as a computational proof-of-concept for generating prioritized therapeutic hypotheses, rather than as a universal target-discovery solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability<\/jats:title>\n                    <jats:p>Code is available at: https:\/\/github.com\/NYCU-ICLAB\/TargetPrior and archived on Zenodo (DOI: 10.5281\/zenodo.20394263).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag635","type":"journal-article","created":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T13:27:10Z","timestamp":1787837230000},"source":"Crossref","is-referenced-by-count":0,"title":["TargetPrior: a miRNA-signature embedded evolutionary learning framework for prioritizing drug targets in acute myeloid leukemia"],"prefix":"10.1093","volume":"42","author":[{"given":"Ting-Yu","family":"Chen","sequence":"first","affiliation":[{"name":"Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University , Hsinchu,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1901-8353","authenticated-orcid":false,"given":"Shinn-Ying","family":"Ho","sequence":"additional","affiliation":[{"name":"Institute of Molecular Medicine and Bioengineering, National Yang Ming Chiao Tung University , Hsinchu,","place":["Taiwan"]},{"name":"Department of Biological Science and Technology, National Yang Ming Chiao Tung University , Hsinchu,","place":["Taiwan"]},{"name":"Institute of Bioinformatics and Systems Biology, National Yang Ming Chiao Tung University , Hsinchu,","place":["Taiwan"]},{"name":"Center for Intelligent Drug Systems and Smart Bio-devices (IDS2B), National Yang Ming Chiao Tung University , Hsinchu,","place":["Taiwan"]},{"name":"College of Health Sciences, Kaohsiung Medical University , Kaohsiung,","place":["Taiwan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,8,27]]},"reference":[{"key":"2026090818352980100_btag635-B1","doi-asserted-by":"crossref","first-page":"942126","DOI":"10.3389\/fphar.2022.942126","article-title":"Bioinformatics and network-based screening and discovery of potential molecular targets and small molecular drugs for breast cancer","volume":"13","author":"Alam","year":"2022","journal-title":"Front Pharmacol"},{"key":"2026090818352980100_btag635-B2","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1007\/s40265-021-01574-2","article-title":"Sotorasib: first approval","volume":"81","author":"Blair","year":"2021","journal-title":"Drugs"},{"key":"2026090818352980100_btag635-B3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1214\/ss\/1009213726","article-title":"Statistical modeling: the two cultures","volume":"16","author":"Breiman","year":"2001","journal-title":"Stat Sci"},{"key":"2026090818352980100_btag635-B3311436","doi-asserted-by":"publisher","first-page":"e22532","DOI":"10.1016\/j.heliyon.2023.e22532","article-title":"Comprehensive analysis of cuproptosis-associated LncRNAs predictive value and related CeRNA network in Acute myeloid leukemia","volume":"9","author":"Cao","year":"2023","journal-title":"Heliyon"},{"key":"2026090818352980100_btag635-B4","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc2294","article-title":"The properties of high-dimensional data spaces: implications for exploring gene and protein expression data","volume":"8","author":"Clarke","year":"2008","journal-title":"Nat Rev Cancer"},{"key":"2026090818352980100_btag635-B5","doi-asserted-by":"crossref","first-page":"lqae096","DOI":"10.1093\/nargab\/lqae096","article-title":"A new method for network bioinformatics identifies novel drug targets for mucinous ovarian carcinoma","volume":"6","author":"Craig","year":"2024","journal-title":"NAR Genom Bioinform"},{"key":"2026090818352980100_btag635-B6","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.cmet.2018.03.004","article-title":"RNA-targeted therapeutics","volume":"27","author":"Crooke","year":"2018","journal-title":"Cell Metab"},{"key":"2026090818352980100_btag635-B7","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrc.2017.36","article-title":"Drugging the 'undruggable\u2019 cancer targets","volume":"17","author":"Dang","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"2026090818352980100_btag635-B8","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s11229-015-0983-y","article-title":"Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine","volume":"195","author":"Darrason","year":"2018","journal-title":"Synthese"},{"key":"2026090818352980100_btag635-B9","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1109\/TIT.2006.871582","article-title":"Compressed sensing","volume":"52","author":"Donoho","year":"2006","journal-title":"IEEE Trans Inform Theory"},{"key":"2026090818352980100_btag635-B10","doi-asserted-by":"crossref","first-page":"5923","DOI":"10.1073\/pnas.0601231103","article-title":"Thousands of samples are needed to generate a robust gene list for predicting outcome in cancer","volume":"103","author":"Ein-Dor","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090818352980100_btag635-B2440256","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/bjh.18746","article-title":"A miRNA signature related to stemness identifies high-risk patients in paediatric acute myeloid leukaemia","volume":"202","author":"Esperanza-Cebollada","year":"2023","journal-title":"Br J Haematol"},{"key":"2026090818352980100_btag635-B11","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1126\/science.287.5460.1969","article-title":"Mechanism-based target identification and drug discovery in cancer research","volume":"287","author":"Gibbs","year":"2000","journal-title":"Science"},{"key":"2026090818352980100_btag635-B1896725","doi-asserted-by":"publisher","first-page":"2130","DOI":"10.1038\/sj.leu.2403924","article-title":"Treatment strategy and long-term results in paediatric patients treated in consecutive UK AML trials","volume":"19","author":"Gibson","year":"2005","journal-title":"Leukemia"},{"key":"2026090818352980100_btag635-B12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.tips.2021.05.006","article-title":"Membrane protein production and formulation for drug discovery","volume":"42","author":"Gulezian","year":"2021","journal-title":"Trends Pharmacol Sci"},{"key":"2026090818352980100_btag635-B13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nature12831","article-title":"Inconsistency in large pharmacogenomic studies","volume":"504","author":"Haibe-Kains","year":"2013","journal-title":"Nature"},{"key":"2026090818352980100_btag635-B14","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1109\/TSMCB.2003.817090","article-title":"Inheritable genetic algorithm for biobjective 0\/1 combinatorial optimization problems and its applications","volume":"34","author":"Ho","year":"2004","journal-title":"IEEE Trans Syst Man Cybern B Cybern"},{"key":"2026090818352980100_btag635-B15","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1109\/TEVC.2004.835176","article-title":"Intelligent evolutionary algorithms for large parameter optimization problems","volume":"8","author":"Ho","year":"2004","journal-title":"IEEE Trans Evol Computat"},{"key":"2026090818352980100_btag635-B16","doi-asserted-by":"crossref","first-page":"D33","DOI":"10.1093\/nar\/gky822","article-title":"AnimalTFDB 3.0: a comprehensive resource for annotation and prediction of animal transcription factors","volume":"47","author":"Hu","year":"2019","journal-title":"Nucleic Acids Res"},{"key":"2026090818352980100_btag635-B17","doi-asserted-by":"crossref","first-page":"6395","DOI":"10.1038\/s41388-021-02055-2","article-title":"A highly annotated database of genes associated with platinum resistance in cancer","volume":"40","author":"Huang","year":"2021","journal-title":"Oncogene"},{"key":"2026090818352980100_btag635-B1889929","doi-asserted-by":"crossref","DOI":"10.1093\/bib\/bbac397","article-title":"Updated review of advances in microRNAs and complex diseases: experimental results, databases, webservers and data fusion","volume":"23","author":"Huang","year":"2022","journal-title":"Brief Bioinform"},{"key":"2026090818352980100_btag635-B18","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/S0140-6736(05)17878-7","article-title":"Microarrays and molecular research: noise discovery?","volume":"365","author":"Ioannidis","year":"2005","journal-title":"Lancet"},{"key":"2026090818352980100_btag635-B80163217","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1038\/s41586-022-04437-2","article-title":"Effective drug combinations in breast, colon and pancreatic cancer cells","volume":"603","author":"Jaaks","year":"2022","journal-title":"Nature"},{"key":"2026090818352980100_btag635-B19","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.bbagrm.2014.04.003","article-title":"MicroRNAs as regulators and mediators of c-MYC function","volume":"1849","author":"Jackstadt","year":"2015","journal-title":"Biochim Biophys Acta"},{"key":"2026090818352980100_btag635-B19330308","first-page":"103379","article-title":"Mrna-lncRNA geneexpression signature for predicting pediatric AML relapse","volume":"71","author":"Kulaeva","year":"2023","journal-title":"Curr Res Transl Med"},{"key":"2026090818352980100_btag635-B20","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s00277-023-05111-x","article-title":"Amsacrine-based induction therapy in AML patients with cardiac comorbidities: a retrospective single-center analysis","volume":"102","author":"Kuron","year":"2023","journal-title":"Ann Hematol"},{"key":"2026090818352980100_btag635-B0533217","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/s12964-020-00627-5","article-title":"Drug resistance and Cancer stem cells","volume":"19","author":"Li","year":"2021","journal-title":"Cell Commun Signal"},{"key":"2026090818352980100_btag635-B97537","doi-asserted-by":"publisher","first-page":"3964","DOI":"10.1200\/JCO.2017.74.7451","article-title":"Microrna expression-based model indicates event-free survival in pediatric acute myeloid leukemia","volume":"35","author":"Lim","year":"2017","journal-title":"J Clin Oncol"},{"key":"2026090818352980100_btag635-B21","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1038\/s41467-019-10920-8","article-title":"Membrane protein-regulated networks across human cancers","volume":"10","author":"Lin","year":"2019","journal-title":"Nat Commun"},{"key":"2026090818352980100_btag635-B22","doi-asserted-by":"crossref","first-page":"7039","DOI":"10.1200\/JCO.2023.41.16_suppl.7039","article-title":"Analysis of short-term efficacy and safety of mitoxantrone hydrochloride liposome regimen therapy in adult acute myeloid leukemia","volume":"41","author":"Ma","year":"2023","journal-title":"JCO"},{"key":"2026090818352980100_btag635-B23","doi-asserted-by":"crossref","first-page":"1257601","DOI":"10.1126\/science.1257601","article-title":"Disease networks. Uncovering disease-disease relationships through the incomplete interactome","volume":"347","author":"Menche","year":"2015","journal-title":"Science"},{"key":"2026090818352980100_btag635-B24","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.trci.2017.10.005","article-title":"Drug discovery and development: role of basic biological research","volume":"3","author":"Mohs","year":"2017","journal-title":"Alzheimers Dement (N Y)"},{"key":"2026090818352980100_btag635-B25","doi-asserted-by":"crossref","first-page":"e2025581118","DOI":"10.1073\/pnas.2025581118","article-title":"Network medicine framework for identifying drug-repurposing opportunities for COVID-19","volume":"118","author":"Morselli Gysi","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026090818352980100_btag635-B5148522","doi-asserted-by":"publisher","first-page":"101192","DOI":"10.1016\/j.beha.2020.101192","article-title":"Acute myeloid leukemia and artificial intelligence, algorithms and new scores","volume":"33","author":"Radakovich","year":"2020","journal-title":"Best Pract Res Clin Haematol"},{"key":"2026090818352980100_btag635-B4954918","doi-asserted-by":"crossref","first-page":"896426","DOI":"10.3389\/fonc.2022.896426","article-title":"Drug resistance mechanisms of Acute Myeloid Leukemia stem cells","volume":"12","author":"Niu","year":"2022","journal-title":"Front Oncol"},{"key":"2026090818352980100_btag635-B26","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/j.molcel.2007.05.017","article-title":"Transcriptional activation of miR-34a contributes to p53-mediated apoptosis","volume":"26","author":"Raver-Shapira","year":"2007","journal-title":"Mol Cell"},{"key":"2026090818352980100_btag635-B27","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1200\/JCO.24.00235","article-title":"Single or double induction with 7\u2009+\u20093 containing standard or high-dose daunorubicin for newly diagnosed AML: the randomized DaunoDouble trial by the study alliance leukemia","volume":"43","author":"R\u00f6llig","year":"2025","journal-title":"J Clin Oncol"},{"key":"2026090818352980100_btag635-B8165225","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/B978-0-323-85873-1.00015-0","author":"Rout","year":"2022","journal-title":"Combination Drugdelivery Approach as an Effective Therapy for Various Diseases"},{"key":"2026090818352980100_btag635-B28","doi-asserted-by":"crossref","first-page":"lqae022","DOI":"10.1093\/nargab\/lqae022","article-title":"An evolutionary learning-based method for identifying a circulating miRNA signature for breast cancer diagnosis prediction","volume":"6","author":"Sathipati","year":"2024","journal-title":"NAR Genom Bioinform"},{"key":"2026090818352980100_btag635-B29","first-page":"100272","article-title":"Treatment outcome of doxorubicin versus idarubicin in adult acute myeloid leukemia","volume":"16","author":"Sherif","year":"2021","journal-title":"Leuk Res Rep"},{"key":"2026090818352980100_btag635-B30","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1002\/ddr.22115","article-title":"Artificial intelligence revolutionizing drug development: exploring opportunities and challenges","volume":"84","author":"Tiwari","year":"2023","journal-title":"Drug Dev Res"},{"key":"2026090818352980100_btag635-B32512150","doi-asserted-by":"crossref","first-page":"865111","DOI":"10.3389\/fgene.2022.865111","article-title":"Explorationof differentially expressed mRNAs and miRNAs for pediatric acute myeloidleukemia","volume":"13","author":"Wang","year":"2022","journal-title":"Front Genet"},{"key":"2026090818352980100_btag635-B9431209","doi-asserted-by":"crossref","first-page":"e06447","DOI":"10.1002\/advs.202506447","article-title":"A network-driven framework for drug response precision prediction of Acute Myeloid Leukemia","volume":"12","author":"Wang","year":"2025","journal-title":"Adv Sci (Weinh)"},{"key":"2026090818352980100_btag635-B6435644","doi-asserted-by":"publisher","first-page":"8771","DOI":"10.7150\/thno.62642","article-title":"Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry","volume":"11","author":"Wang","year":"2021","journal-title":"Theranostics"},{"key":"2026090818352980100_btag635-B4139208","doi-asserted-by":"publisher","first-page":"3333","DOI":"10.18632\/aging.101985","article-title":"Prediction of competing endogenous RNA coexpression network as prognostic markers in AML","volume":"11","author":"Wang","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"2026090818352980100_btag635-B31","doi-asserted-by":"crossref","first-page":"D1074","DOI":"10.1093\/nar\/gkx1037","article-title":"DrugBank 5.0: a major update to the DrugBank database for 2018","volume":"46","author":"Wishart","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026090818352980100_btag635-B32","doi-asserted-by":"crossref","first-page":"1486","DOI":"10.1038\/s41417-024-00818-z","article-title":"Arsenic trioxide and p97 inhibitor synergize against acute myeloid leukemia by targeting nascent polypeptides and activating the ZAKalpha-JNK pathway","volume":"31","author":"Xie","year":"2024","journal-title":"Cancer Gene Ther"},{"key":"2026090818352980100_btag635-B33","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1038\/s41392-023-01589-z","article-title":"Recent advances in targeting the \"undruggable\" proteins: from drug discovery to clinical trials","volume":"8","author":"Xie","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"2026090818352980100_btag635-B7227933","doi-asserted-by":"publisher","first-page":"1414","DOI":"10.1158\/1535-7163.MCT-14-0625","article-title":"Chemotherapy-regulated microRNA-125-HER2 pathway as a novel therapeutic target for Trastuzumab-Mediated Cellular Cytotoxicity in Small Cell Lung Cancer","volume":"14","author":"Yagishita","year":"2015","journal-title":"Mol Cancer Ther"},{"key":"2026090818352980100_btag635-B34","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1093\/carcin\/bgad062","article-title":"Prognostic microRNA signature for estimating survival in patients with hepatocellular carcinoma","volume":"44","author":"Yerukala Sathipati","year":"2023","journal-title":"Carcinogenesis"},{"key":"2026090818352980100_btag635-B35","doi-asserted-by":"crossref","first-page":"7507","DOI":"10.1038\/s41598-017-07739-y","article-title":"Identifying the miRNA signature associated with survival time in patients with lung adenocarcinoma using miRNA expression profiles","volume":"7","author":"Yerukala Sathipati","year":"2017","journal-title":"Sci Rep"},{"key":"2026090818352980100_btag635-B36","doi-asserted-by":"crossref","first-page":"e17218","DOI":"10.1016\/j.heliyon.2023.e17218","article-title":"Survival associated miRNA signature in patients with head and neck carcinomas","volume":"9","author":"Yerukala Sathipati","year":"2023","journal-title":"Heliyon"},{"key":"2026090818352980100_btag635-B37","first-page":"100190","article-title":"Artificial intelligence-driven pan-cancer analysis reveals miRNA signatures for cancer stage prediction","volume":"4","author":"Yerukala Sathipati","year":"2023","journal-title":"HGG Adv"},{"key":"2026090818352980100_btag635-B38","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1038\/s41392-022-00994-0","article-title":"Artificial intelligence in cancer target identification and drug discovery","volume":"7","author":"You","year":"2022","journal-title":"Signal Transduct Target Ther"},{"key":"2026090818352980100_btag635-B39","doi-asserted-by":"crossref","first-page":"721","DOI":"10.2147\/DDDT.S288859","article-title":"The risks of miRNA therapeutics: in a drug target perspective","volume":"15","author":"Zhang","year":"2021","journal-title":"Drug Des Devel Ther"},{"key":"2026090818352980100_btag635-B40","doi-asserted-by":"crossref","first-page":"101169","DOI":"10.1016\/j.tranon.2021.101169","article-title":"Etoposide, an anticancer drug involved in therapy-related secondary leukemia: enzymes at play","volume":"14","author":"Zhang","year":"2021","journal-title":"Transl Oncol"},{"key":"2026090818352980100_btag635-B41","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1002\/ajh.26386","article-title":"Optimization of idarubicin and cytarabine induction regimen with homoharringtonine for newly diagnosed acute myeloid leukemia patients based on the peripheral blast clearance rate: a single-arm, phase 2 trial (RJ-AML 2014)","volume":"97","author":"Zhang","year":"2022","journal-title":"Am J Hematol"},{"key":"2026090818352980100_btag635-B42","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/j.1467-9868.2005.00503.x","article-title":"Regularization and variable selection via the elastic net","volume":"67","author":"Zou","year":"2005","journal-title":"J R Stat Soc Ser B Stat Methodol"}],"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/advance-article-pdf\/doi\/10.1093\/bioinformatics\/btag635\/70818941\/btag635.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/42\/9\/btag635\/70818941\/btag635.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/42\/9\/btag635\/70818941\/btag635.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:35:46Z","timestamp":1788906946000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/doi\/10.1093\/bioinformatics\/btag635\/8771777"}},"subtitle":[],"editor":[{"given":"A Ercument","family":"Cicek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2026,8,27]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,8,31]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/btag635","relation":{},"ISSN":["1367-4803","1367-4811"],"issn-type":[{"value":"1367-4803","type":"print"},{"value":"1367-4811","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,8,27]]},"article-number":"btag635"}}