{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T19:44:14Z","timestamp":1792266254368,"version":"4.4.0"},"reference-count":25,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["#PJT- 180472"],"award-info":[{"award-number":["#PJT- 180472"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canada Research Chairs program","id":[{"id":"https:\/\/ror.org\/0517h6h17","id-type":"ROR","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Summary<\/jats:title>\n                    <jats:p>FAIDR-Desi is a non-technical user interface for design of intrinsically disordered regions (IDRs) based on greedy optimization of sequence features\u00a0(simple sequence statistics\u00a0correlated with IDR function,\u00a0including\u00a0amino acid composition, residue patterning and short linear interaction motifs),\u00a0using\u00a0more features (127) than\u00a0other IDR design approaches. FAIDR-Desi can be used to design synthetic IDR\u00a0mimics\u00a0to establish\u00a0feature\u00a0sufficiency\u00a0for\u00a0function, or to knock out features to show\u00a0necessity\u00a0for function, exemplified with\u00a0experiments\u00a0on\u00a0the\u00a0yeast Cox15 mitochondrial targeting signal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Availability and implementation<\/jats:title>\n                    <jats:p>Software is freely available on the web at https:\/\/moses-lab.github.io\/faidr_desi\/ and an archival version of the source code is available on Zenodo (https:\/\/doi.org\/10.5281\/zenodo.22036189).<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/bioinformatics\/btag715","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T04:22:32Z","timestamp":1790310152000},"source":"Crossref","is-referenced-by-count":0,"title":["FAIDR-Desi: interactive software for feature analysis 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