{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T01:32:03Z","timestamp":1791163923155,"version":"4.1.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"16","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Motivation: Interchain \u03b2-sheet (ICBS) interactions occur widely in protein quaternary structures, interactions between proteins and protein aggregation. These interactions play a central role in many biological processes and in diseases ranging from AIDS and cancer to anthrax and Alzheimer's.<\/jats:p>\n               <jats:p>Results: We have created a comprehensive database of ICBS interactions that is updated on a weekly basis and allows entries to be sorted and searched by relevance and other criteria through a simple Web interface. We derive a simple ICBS index to quantify the relative contributions of the \u03b2-ladders in the overall interchain interaction and compute first- and second-order statistics regarding amino acid composition and pairing at different relative positions in the \u03b2-strands. Analysis of the database reveals a 15.8% prevalence of significant ICBS interactions, the majority of which involve the formation of antiparallel \u03b2-sheets and many of which involve the formation of dimers and oligomers. The frequencies of amino acids in ICBS interfaces are similar to those in intrachain \u03b2-sheet interfaces. A full range of non-covalent interactions between side chains complement the hydrogen-bonding interactions between the main chains. Polar amino acids pair preferentially with polar amino acids and non-polar amino acids pair preferentially with non-polar amino acids among antiparallel (i, j) pairs. We anticipate that the statistics and insights gained from the database will guide the development of agents that control interchain \u03b2-sheet interactions and that the database will help identify new protein interactions and targets for these agents.<\/jats:p>\n               <jats:p>Availability: The database is available at: http:\/\/www.igb.uci.edu\/servers\/icbs\/<\/jats:p>\n               <jats:p>Supplementary Information: \u00a0http:\/\/www.igb.uci.edu\/servers\/icbs\/<\/jats:p>","DOI":"10.1093\/bioinformatics\/bth326","type":"journal-article","created":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:33:47Z","timestamp":1086050027000},"page":"2767-2777","source":"Crossref","is-referenced-by-count":49,"title":["ICBS: a database of interactions between protein chains mediated by \u03b2-sheet formation"],"prefix":"10.1093","volume":"20","author":[{"given":"Yimeng","family":"Dou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Fran\u00e7ois","family":"Baisn\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluca","family":"Pollastri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yann","family":"P\u00e9cout","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Nowick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Baldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2004,5,27]]},"container-title":["Bioinformatics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/16\/2767\/48906415\/bioinformatics_20_16_2767.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article-pdf\/20\/16\/2767\/48906415\/bioinformatics_20_16_2767.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T16:38:57Z","timestamp":1674664737000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bioinformatics\/article\/20\/16\/2767\/236944"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5,27]]},"references-count":0,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2004,11,1]]}},"URL":"https:\/\/doi.org\/10.1093\/bioinformatics\/bth326","relation":{},"ISSN":["1367-4811","1367-4803"],"issn-type":[{"value":"1367-4811","type":"electronic"},{"value":"1367-4803","type":"print"}],"subject":[],"published-other":{"date-parts":[[2004,11,1]]},"published":{"date-parts":[[2004,5,27]]}}}