{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:35:10Z","timestamp":1788194110460,"version":"build-2803163510"},"reference-count":87,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T00:00:00Z","timestamp":1579219200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000071","name":"NICHD","doi-asserted-by":"publisher","award":["R21HD092739"],"award-info":[{"award-number":["R21HD092739"]}],"id":[{"id":"10.13039\/100000071","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"AMED","doi-asserted-by":"publisher","award":["19gk0210021h0001"],"award-info":[{"award-number":["19gk0210021h0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endometriosis is a common gynecological disease, which causes chronic pelvic pain and infertility in women of reproductive age. Due to limited efficacy of current treatment options, a critical need exists to develop new and effective treatments for endometriosis. Niclosamide is an efficacious and FDA-approved drug for the treatment of helminthosis in humans that has been used for decades. We have reported that niclosamide reduces growth and progression of endometriosis-like lesions via targeting STAT3 and NF\u0138B signaling in a mouse model of endometriosis. To examine the effects of niclosamide on macrophage-induced inflammation in endometriosis, a total of 29 stage III\u2013IV endometrioma samples were used to isolate human endometriotic stromal cells (hESCs). M1 or M2 macrophages were isolated and differentiated from fresh human peripheral blood samples. Then, hESCs were cultured in conditioned media (CM) from macrophages with\/without niclosamide. Niclosamide dose dependently reduced cell viability and the activity of STAT3 and NF\u03baB signaling in hESCs. While macrophage CM stimulated cell viability in hESCs, niclosamide inhibited this stimulation. Macrophage CM stimulated the secretion of proinflammatory cytokines and chemokines from hESCs. Most of these secreted factors were inhibited by niclosamide. These results indicate that niclosamide is able to reduce macrophage-induced cell viability and cytokine\/chemokine secretion in hESCs by inhibiting inflammatory mechanisms via STAT3 and\/or NF\u03baB signaling.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa010","type":"journal-article","created":{"date-parts":[[2020,1,17]],"date-time":"2020-01-17T07:16:40Z","timestamp":1579245400000},"page":"1011-1019","source":"Crossref","is-referenced-by-count":30,"title":["Niclosamide suppresses macrophage-induced inflammation in endometriosis\u2020"],"prefix":"10.1093","volume":"102","author":[{"given":"Nikola","family":"Sekulovski","sequence":"first","affiliation":[{"name":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allison E","family":"Whorton","sequence":"first","affiliation":[{"name":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Tanaka","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasushi","family":"Hirota","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Faculty of Medicine, The University of Tokyo, Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingxin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"James A","family":"MacLean","sequence":"first","affiliation":[{"name":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois 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Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Wilson","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, Illinois USA"},{"name":"Center for Clinical Research, Southern Illinois University School of Medicine, Springfield, Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Hayashi","sequence":"first","affiliation":[{"name":"Department of Physiology, Southern Illinois University School of Medicine, Carbondale, Illinois USA"},{"name":"Department of Obstetrics and Gynecology, Southern Illinois University School of Medicine, Springfield, Illinois 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