{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T13:34:10Z","timestamp":1780666450676,"version":"3.54.1"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T00:00:00Z","timestamp":1585267200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004897","name":"Pennsylvania Department of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004897","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Society for Reproductive Medicine Research"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 GM106262"],"award-info":[{"award-number":["R01 GM106262"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,6,23]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The number and quality of oocytes, as well as the decline in both of these parameters with age, determines reproductive potential in women. However, the underlying mechanisms of this diminution are incompletely understood. Previously, we identified novel roles for CHTF18 (Chromosome Transmission Fidelity Factor 18), a component of the conserved Replication Factor C-like complex, in male fertility and gametogenesis. Currently, we reveal crucial roles for CHTF18 in female meiosis and oocyte development. Chtf18\u2212\/\u2212 female mice are subfertile and have fewer offspring beginning at 6\u00a0months of age. Consistent with age-dependent subfertility, Chtf18\u2212\/\u2212 ovaries contain fewer follicles at all stages of folliculogenesis than wild type ovaries, but the decreases are more significant at 3 and 6 months of age. By 6 months of age, both primordial and growing ovarian follicle pools are markedly reduced to near depletion. Chromosomal synapsis in Chtf18\u2212\/\u2212 oocytes is complete, but meiotic recombination is impaired resulting in persistent DNA double-strand breaks, fewer crossovers, and early homolog disjunction during meiosis I. Consistent with poor oocyte quality, the majority of Chtf18\u2212\/\u2212 oocytes fail to progress to metaphase II following meiotic resumption and a significant percentage of those that do progress are aneuploid. Collectively, our findings indicate critical functions for CHTF18 in ensuring both the quantity and quality of the mammalian oocyte pool.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa036","type":"journal-article","created":{"date-parts":[[2020,3,27]],"date-time":"2020-03-27T11:06:24Z","timestamp":1585307184000},"page":"24-35","source":"Crossref","is-referenced-by-count":10,"title":["CHTF18 ensures the quantity and quality of the ovarian reserve\u2020"],"prefix":"10.1093","volume":"103","author":[{"given":"Rebecca A","family":"Holton","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail M","family":"Harris","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barenya","family":"Mukerji","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanu","family":"Singh","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdusy","family":"Dia","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen M","family":"Berkowitz","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology"},{"name":"Department of Obstetrics and Gynecology, Drexel University College of Medicine, Philadelphia, PA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,27]]},"reference":[{"key":"2020062407333915200_ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1086\/513911","article-title":"Human female meiosis: new insights into an error-prone 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