{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T14:09:17Z","timestamp":1790604557772,"version":"4.1.0"},"reference-count":133,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD097087"],"award-info":[{"award-number":["R01HD097087"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Semen liquefaction is a proteolytic process where a gel-like ejaculated semen becomes watery due to the enzymatic activity of prostate-derived serine proteases in the female reproductive tract. The liquefaction process is crucial for the sperm to gain their motility and successful transport to the fertilization site in Fallopian tubes (or oviducts in animals). Hyperviscous semen or failure in liquefaction is one of the causes of male infertility. Therefore, the biochemical inhibition of serine proteases in the female reproductive tract after ejaculation is a prime target for novel contraceptive development. Herein, we will discuss protein components in the ejaculates responsible for semen liquefaction and any developments of contraceptive methods in the past that involve the liquefaction process.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa075","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T08:57:02Z","timestamp":1589446622000},"page":"411-426","source":"Crossref","is-referenced-by-count":49,"title":["Mechanism of semen liquefaction and its potential for a novel non-hormonal contraception\u2020"],"prefix":"10.1093","volume":"103","author":[{"given":"Prashanth","family":"Anamthathmakula","sequence":"first","affiliation":[{"name":"School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wipawee","family":"Winuthayanon","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, Center for Reproductive Biology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,14]]},"reference":[{"key":"2020093001145016500_ref1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1093\/humupd\/dmi047","article-title":"Sperm transport in the female reproductive tract","volume":"12","author":"Suarez","year":"2006","journal-title":"Hum Reprod Update"},{"key":"2020093001145016500_ref2","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/nrurol.2016.89","article-title":"The role of the prostate in male fertility, health and disease","volume":"13","author":"Verze","year":"2016","journal-title":"Nat Rev Urol"},{"key":"2020093001145016500_ref3","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/nrurol.2014.74","article-title":"Seminal plasma as a diagnostic fluid for male reproductive system disorders","volume":"11","author":"Drabovich","year":"2014","journal-title":"Nat Rev Urol"},{"key":"2020093001145016500_ref4","doi-asserted-by":"crossref","first-page":"4559","DOI":"10.1073\/pnas.89.10.4559","article-title":"Molecular cloning of epididymal and seminal vesicular transcripts encoding a semenogelin-related protein","volume":"89","author":"Lilja","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2020093001145016500_ref5","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0021-9258(18)94272-9","article-title":"Semenogelin, the predominant protein in human semen. 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