{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:55:17Z","timestamp":1761897317325,"version":"3.37.3"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,6,24]],"date-time":"2020-06-24T00:00:00Z","timestamp":1592956800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100002865","name":"Chongqing Science and Technology Commission","doi-asserted-by":"publisher","award":["cstc2017jcyjBX0045"],"award-info":[{"award-number":["cstc2017jcyjBX0045"]}],"id":[{"id":"10.13039\/501100002865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key R&D Program of China","award":["2018YFC1004103"],"award-info":[{"award-number":["2018YFC1004103"]}]},{"name":"Science and Technology Commission of Chongqing","award":["cstc2017jcyjBX0045"],"award-info":[{"award-number":["cstc2017jcyjBX0045"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771613","81520108013","81871189","81671488","81901506","81871189","81671488","81771613","81520108013"],"award-info":[{"award-number":["81771613","81520108013","81871189","81671488","81901506","81871189","81671488","81771613","81520108013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Science and Technology of China","award":["2018YFC1004103"],"award-info":[{"award-number":["2018YFC1004103"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Fetal growth restriction (FGR) is a condition in which a newborn fails to achieve his or her prospective hereditary growth potential. This condition is associated with high newborn mortality, second only to that associated with premature birth. FGR is associated with maternal, fetal, and placental abnormalities. Although the placenta is considered to be an important organ for supplying nutrition for fetal growth, research on FGR is limited, and treatment through the placenta remains challenging, as neither proper uterine intervention nor its pathogenesis have been fully elucidated. Yes-associated protein (YAP), as the effector of the Hippo pathway, is widely known to regulate organ growth and cancer development. Therefore, the correlation of the placenta and YAP was investigated to elucidate the pathogenic mechanism of FGR. Placental samples from humans and mice were collected for histological and biomechanical analysis. After investigating the location and role of YAP in the placenta by immunohistochemistry, we observed that YAP and cytokeratin 7 have corresponding locations in human and mouse placentas. Moreover, phosphorylated YAP (p-YAP) was upregulated in FGR and gradually increased as gestational age increased during pregnancy. Cell function experiments and mRNA-Seq demonstrated impaired YAP activity mediated by extracellular signal-regulated kinase inhibition. Established FGR-like mice also recapitulated a number of the features of human FGR. The results of this study may help to elucidate the association of FGR development with YAP and provide an intrauterine target that may be helpful in alleviating placental dysfunction.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa112","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T08:14:19Z","timestamp":1593072859000},"page":"866-879","source":"Crossref","is-referenced-by-count":13,"title":["Phosphorylation of Yes-associated protein impairs trophoblast invasion and migration: implications for the pathogenesis of fetal growth restriction\u2020"],"prefix":"10.1093","volume":"103","author":[{"given":"Hao","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Health Center for Women and Children, Chongqing, 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Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiang","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuehai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal 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of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"},{"name":"Laboratory of Reproductive Biology, School of Public Health and Management, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongbo","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China"},{"name":"State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, China"},{"name":"International Collaborative Laboratory of Reproduction and Development of Chinese Ministry of Education, Chongqing Medical University, Chongqing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Kilby","sequence":"additional","affiliation":[{"name":"Centre for Women's and New Born Health, Institute of Metabolism and Systems Research, University of Birmingham, Birmingham, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[{"name":"Cancer, Disease and Developmental Epigenetics, Murdoch Children\u2019s Research Institute, Parkville, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip N","family":"Baker","sequence":"additional","affiliation":[{"name":"College of Medicine, Biological 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