{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T13:57:34Z","timestamp":1787147854112,"version":"build-2736575974"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T00:00:00Z","timestamp":1598918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Foundation to Support Science and Research in S\u00e3o Paulo State","award":["2012\/17275-0"],"award-info":[{"award-number":["2012\/17275-0"]}]},{"name":"DC Damasceno","award":["2019\/06735-9"],"award-info":[{"award-number":["2019\/06735-9"]}]},{"name":"DC Damasceno","award":["2011\/23721-0"],"award-info":[{"award-number":["2011\/23721-0"]}]},{"name":"DC Damasceno","award":["2013\/16548-5"],"award-info":[{"award-number":["2013\/16548-5"]}]},{"DOI":"10.13039\/501100003593","name":"National Council for Scientific and Technological Development","doi-asserted-by":"publisher","award":["307978\/2014_1"],"award-info":[{"award-number":["307978\/2014_1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,10,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preexisting\/pregestational diabetes enhances the risk of birth defects. Several factors have been involved during the implantation process, such as cytokines (granulocyte-macrophage\u2013colony-stimulating factor [GM-CSF]). The objective was to evaluate the effects of two levels of diabetes on the redox status of preimplantation embryos during the implantation process to comprehend how both are involved in embryo and fetal viability against maternal diabetes. Female Sprague\u2013Dawley rats received streptozotocin at birth (mild diabetes [MD]) or at adulthood (severe diabetes [SD]) to obtain two experimental diabetes intensities. After confirming the diabetic status, the nondiabetic and diabetic groups were mated around day 110 of life. At gestational day (GD) 21, fetuses were assessed for viability and malformations and ovaries for embryo loss before implantation. Other pregnant nondiabetic and diabetic rats were sacrificed at GD2\u20134 for maternal and preimplantation embryo oxidative stress markers, maternal serum insulin, uterine fluid GM-CSF, and preimplantation embryo morphological analysis. MD and SD caused abnormal redox levels, lower GM-CSF and insulin levels during the preimplantation period, and embryonic loss before implantation. SD caused lower fetal viability and higher fetal malformation percentages at GD21. The SD dam-derived preimplantation embryos presented lower glutathione levels and higher thiobarbituric acid reactive substances concentration at GD3 and an increased frequency of abnormal preimplantation embryos at GD4. In conclusion, preexisting diabetes leads to complications in the implantation process. Furthermore, maternal oxidative stress and other metabolic changes alter the redox state and morphological structure of preimplantation embryos, contributing to damaged growth and development in late pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa151","type":"journal-article","created":{"date-parts":[[2020,9,1]],"date-time":"2020-09-01T07:52:22Z","timestamp":1598946742000},"page":"938-950","source":"Crossref","is-referenced-by-count":28,"title":["Severity of prepregnancy diabetes on the fetal malformations and viability associated with early embryos in rats\u2020"],"prefix":"10.1093","volume":"103","author":[{"given":"Aline","family":"Bueno","sequence":"first","affiliation":[{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp), Botucatu, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuri Karen","family":"Sinzato","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp), Botucatu, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Tadeu","family":"Volpato","sequence":"additional","affiliation":[{"name":"Laboratory of System Physiology and Reproductive Toxicology, Institute of Biological and Health Sciences, Federal University of Mato Grosso (UFMT), Barra do Gar\u00e7as, Mato Grosso State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciane Quintanilha","family":"Gallego","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp), Botucatu, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Felipe","family":"Perecin","sequence":"additional","affiliation":[{"name":"Faculty of Animal Science and Food Engineering, Department of Veterinary Medicine, University of S\u00e3o Paulo (USP), Pirassununga, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiago","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Center of Natural and Human Sciences (CCNH), Federal University of ABC (UFABC), Santo Andr\u00e9, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e9bora Cristina","family":"Damasceno","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Research on Gynecology and Obstetrics, Postgraduate Course on Tocogynecology, Botucatu Medical School, S\u00e3o Paulo State University (Unesp), Botucatu, S\u00e3o Paulo State, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,1]]},"reference":[{"key":"2020110400511264400_ref1","doi-asserted-by":"crossref","first-page":"e228","DOI":"10.1097\/AOG.0000000000002960","article-title":"Pregestational diabetes mellitus","volume":"132","author":"ACOG - American College of Obstetrics and Gynecology. 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Sci"},{"key":"2020110400511264400_ref47","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jri.2017.12.003","article-title":"Embryotoxic cytokines-potential roles in embryo loss and fetal programming","volume":"125","author":"Robertson","year":"2018","journal-title":"J Reprod Immunol"},{"key":"2020110400511264400_ref48","first-page":"1","article-title":"Metabolism of the preimplantation mammalian embryo","volume":"6","author":"Biggers","year":"1973","journal-title":"Adv Reprod Physiol"},{"key":"2020110400511264400_ref49","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1530\/REP-11-0484","article-title":"Metabolism of the preimplantation embryo: 40 years on","volume":"143","author":"Leese","year":"2012","journal-title":"Reproduction"},{"key":"2020110400511264400_ref50","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1002\/mrd.1080400407","article-title":"Role of glucose in mouse preimplantation embryo 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organogenesis","volume":"37","author":"Higa","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2020110400511264400_ref54","doi-asserted-by":"crossref","first-page":"108163","DOI":"10.1155\/2012\/108163","article-title":"Neonatally induced mild diabetes in rats and its effect on maternal, placental, and fetal parameters","volume":"2012","author":"Sinzato","year":"2012","journal-title":"Exp Diabetes Res"},{"key":"2020110400511264400_ref55","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2337\/diacare.17.2.152","article-title":"A mathematical model for the determination of total area under glucose tolerance and other metabolic curves","volume":"17","author":"Tai","year":"1994","journal-title":"Diabetes Care"},{"key":"2020110400511264400_ref56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/978-1-60327-389-3_10","article-title":"Procedures for somatic cell nuclear transfer in the 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