{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:39:32Z","timestamp":1784068772882,"version":"3.55.0"},"reference-count":197,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T00:00:00Z","timestamp":1599609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There has been a significant annual increase in the number of cases of uterine leiomyomas or fibroids (UF) among women of all races and ages across the world. A fortune is usually spent by the healthcare sector for fibroid-related treatments and management. Molecular studies have established the higher mutational heterogeneity in UF as compared to normal myometrial cells. The contribution of DNA damage and defects in repair responses further increases the mutational burden on the cells. This in turn leads to genetic instability, associated with cancer risk and other adverse reproductive health outcomes. Such and many more growing bodies of literature have highlighted the genetic\/molecular, biochemical and clinical aspects of UF; none the less there appear to be a lacuna bridging the bench to bed gap in addressing and preventing this disease. Presented here is an exhaustive review of not only the molecular mechanisms underlying the predisposition to the disease but also possible strategies to effectively diagnose, prevent, manage, and treat this disease.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa157","type":"journal-article","created":{"date-parts":[[2020,9,9]],"date-time":"2020-09-09T14:24:12Z","timestamp":1599661452000},"page":"58-70","source":"Crossref","is-referenced-by-count":20,"title":["Role of DNA damage and repair mechanisms in uterine fibroid\/leiomyomas: a review"],"prefix":"10.1093","volume":"104","author":[{"given":"Sneh M","family":"Toprani","sequence":"first","affiliation":[{"name":"Department of Biotechnology, University of Mumbai, Kalina, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varsha","family":"Kelkar Mane","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, University of Mumbai, Kalina, Mumbai, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"key":"2021010605001306500_ref1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/humupd\/dmw023","article-title":"Uterine fibroid management: From the present to the future","volume":"22","author":"Donnez","year":"2016","journal-title":"Hum Reprod Update"},{"key":"2021010605001306500_ref2","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1097\/GRF.0000000000000164","article-title":"Epidemiology of uterine fibroids: from menarche to menopause","volume":"59","author":"Wise","year":"2016","journal-title":"Clin Obstet Gynecol"},{"key":"2021010605001306500_ref3","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2015.04.023","article-title":"Severe anemia from heavy menstrual bleeding requires heightened attention","volume":"213","author":"Nelson","year":"2015","journal-title":"Am J Obstet Gynecol"},{"key":"2021010605001306500_ref4","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1111\/1471-0528.14640","article-title":"Epidemiology of uterine fibroids: a systematic review","volume":"124","author":"Stewart","year":"2017","journal-title":"BJOG"},{"key":"2021010605001306500_ref5","article-title":"Breast Cancer Statistics","author":"Breastcancer.org"},{"key":"2021010605001306500_ref6","author":"NCI"},{"key":"2021010605001306500_ref7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1055\/s-0037-1607264","article-title":"Uterine fibroids: burden and unmet medical need","volume":"35","author":"Al-Hendy","year":"2017","journal-title":"Semin Reprod Med"},{"key":"2021010605001306500_ref8","doi-asserted-by":"crossref","first-page":"e0215646","DOI":"10.1371\/journal.pone.0215646","article-title":"Evidence of biomechanical and collagen heterogeneity in uterine fibroids","volume":"14","author":"Jayes","year":"2019","journal-title":"PLoS One"},{"key":"2021010605001306500_ref9","first-page":"2017","article-title":"Uterine fibroids: what\u2019s new?","volume":"6","author":"Williams","year":"2109","journal-title":"F1000 Res"},{"key":"2021010605001306500_ref10","volume-title":"Gynecologic Pathology","author":"Oliva","year":"2009","edition":"1st"},{"key":"2021010605001306500_ref11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ng849","article-title":"Germline mutations in FH predispose to dominantly inherited uterine fibroids, skin leiomyomata and papillary renal cell cancer","volume":"30","author":"Tomlinson","year":"2002","journal-title":"Nat Genet"},{"key":"2021010605001306500_ref12","doi-asserted-by":"crossref","first-page":"17","DOI":"10.7863\/jum.1998.17.1.17","article-title":"Clinical predictors in the natural history of uterine leiomyoma: preliminary study","volume":"17","author":"Tsuda","year":"1998","journal-title":"J Ultrasound Med"},{"key":"2021010605001306500_ref13","first-page":"3","article-title":"Natural history of uterine polyps and leiomyomata","volume":"100","author":"Dewaay","year":"2002","journal-title":"Obstet Gynecol"},{"key":"2021010605001306500_ref14","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/S0015-0282(98)00300-8","article-title":"Correlation between the growth of uterine leiomyomata and estrogen and progesterone receptor content in needle biopsy specimens","volume":"70","author":"Ichimura","year":"1998","journal-title":"Fertil Steril"},{"key":"2021010605001306500_ref15","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1073\/pnas.0808188105","article-title":"Growth of uterine leiomyomata among premenopausal black and white women","volume":"105","author":"Peddada","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"2021010605001306500_ref16","doi-asserted-by":"crossref","first-page":"511","DOI":"10.7863\/jum.1992.11.10.511","article-title":"Longitudinal evaluation of uterine myoma growth during pregnancy. 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Med"},{"key":"2021010605001306500_ref69","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/(SICI)1098-2264(199908)25:4<316::AID-GCC2>3.0.CO;2-0","article-title":"HMGIC expression in human adult and fetal tissues and in uterine leiomyomata","volume":"25","author":"Gattas","year":"1999","journal-title":"Genes Chromosomes Cancer"},{"key":"2021010605001306500_ref70","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/(SICI)1098-2264(199812)23:4<361::AID-GCC12>3.0.CO;2-4","article-title":"Localization and expression of the human estrogen receptor beta gene in uterine leiomyomata","volume":"23","author":"Pedeutour","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"2021010605001306500_ref71","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1078>3.0.CO;2-8","article-title":"Evidence for RAD51L1\/HMGIC fusion in the pathogenesis of uterine 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Rep"},{"key":"2021010605001306500_ref111","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.jobaz.2015.01.006","article-title":"Bisphenol a induces oxidative stress and DNA damage in hepatic tissue of female rat offspring","volume":"71","author":"Eid","year":"2015","journal-title":"J Basic Appl Zool"},{"key":"2021010605001306500_ref112","doi-asserted-by":"crossref","first-page":"1600248","DOI":"10.1002\/advs.201600248","article-title":"Low-dose bisphenol an exposure: a seemingly instigating carcinogenic effect on breast cancer","volume":"4","author":"Wang","year":"2017","journal-title":"Adv Sci"},{"key":"2021010605001306500_ref113","doi-asserted-by":"crossref","first-page":"20405","DOI":"10.1073\/pnas.1010386107","article-title":"Bisphenol A impairs the double-strand break repair machinery in the germline and causes chromosome abnormalities","volume":"107","author":"Allard","year":"2010","journal-title":"Proc Natl Acad Sci 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