{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T07:03:15Z","timestamp":1791442995084,"version":"4.3.3"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Ephrins are ligands of Eph receptors (Ephs); both of which are sorted into two classes, A and B. There are five types of ephrin-As (ephrin-A1\u20135) and three types of ephrin-Bs (ephrin-B1\u20133). Also, there are 10 types of EphAs (EphA1\u201310) and six types of EphBs (EphB1\u20136). Binding of ephrins to the Eph receptors activates signaling cascades that regulate several biological processes such as cellular proliferation, differentiation, migration, angiogenesis, and vascular remodeling. Clarification of their roles in the female reproductive system is crucial to understanding the physiology and pathology of this system. Such knowledge will also create awareness regarding the importance of these molecules in diagnostic, prognostic, and therapeutic medicine. Hence, we have discussed the involvement of these molecules in the physiological and pathological events that occur within the female reproductive system. The evidence so far suggests that the ephrins and the Eph receptors modulate folliculogenesis, ovulation, embryo transport, implantation, and placentation. Abnormal expression of some of these molecules is associated with polycystic ovarian syndrome, ovarian cancer, tubal pregnancy, endometrial cancer, uterine leiomyoma (fibroids), cervical cancer, and preeclampsia, suggesting the need to utilize these molecules in the clinical setting. To enhance a quick development of this gradually emerging field in female reproductive medicine, we have highlighted some \u201cgaps in knowledge\u201d that need prospective investigation.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa171","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T12:56:12Z","timestamp":1600347372000},"page":"71-82","source":"Crossref","is-referenced-by-count":24,"title":["Ephrin and Eph receptor signaling in female reproductive physiology and pathology\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Enoch Appiah","family":"Adu-Gyamfi","sequence":"first","affiliation":[{"name":"Department of Reproductive Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, People\u2019s Republic of China"},{"name":"Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armin","family":"Czika","sequence":"additional","affiliation":[{"name":"Department of Reproductive Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, People\u2019s Republic of China"},{"name":"Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tai-Hang","family":"Liu","sequence":"additional","affiliation":[{"name":"Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip Narteh","family":"Gorleku","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging, School of Medical Sciences, University of Cape Coast, Cape Coast, Republic of Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda Ahenkorah","family":"Fondjo","sequence":"additional","affiliation":[{"name":"Department of Molecular Medicine, School of Medicine and Dentistry, Kwame Nkrumah University of Science and Technology, Kumasi, Republic of Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis Tanam","family":"Djankpa","sequence":"additional","affiliation":[{"name":"Department of Physiology, School of Medical Sciences, University of Cape Coast, Cape Coast, Republic of Ghana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Bin","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Reproductive Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, People\u2019s Republic of China"},{"name":"Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-Xiong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Sciences, School of Basic Medicine, Chongqing Medical University, Chongqing, People\u2019s Republic of China"},{"name":"Joint International Research Laboratory of Reproduction & Development, Chongqing Medical University, Chongqing, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,17]]},"reference":[{"key":"2021010605001517300_ref1","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1038\/bjc.1994.77","article-title":"Eph, the largest known family of putative growth factor receptors","volume":"69","author":"Tuzi","year":"1994","journal-title":"Br J Cancer"},{"key":"2021010605001517300_ref2","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1101\/gad.1973910","article-title":"Eph\/ephrin molecules\u2014A 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