{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:49:00Z","timestamp":1787237340542,"version":"build-2736575974"},"reference-count":85,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T00:00:00Z","timestamp":1601424000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004569","name":"Ministry of Science and Higher Education","doi-asserted-by":"publisher","award":["05\u20131\/KNOW2\/2015"],"award-info":[{"award-number":["05\u20131\/KNOW2\/2015"]}],"id":[{"id":"10.13039\/501100004569","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,1,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Acquisition of endometrial receptivity for embryo implantation is one of the crucial processes during pregnancy and is induced mainly by progesterone and enhanced by conceptus signals. Prokineticin 1 (PROK1) is characterized as a secretory protein with diverse functions in various tissues, including the reproductive tract. PROK1, with its receptor PROKR1, are up-regulated in the porcine endometrium during implantation and in women\u2019s receptive endometrium and decidua. However, the function of PROK1 in embryo-maternal communication has still not been fully elucidated. Hence, we hypothesize that PROK1 is involved in endometrial receptivity development and implantation in pigs. In this study, using the porcine in vivo model of intrauterine infusions of estradiol-17\u03b2 (E2) and prostaglandin E2 (PGE2), we revealed that these hormones elevated endometrial expression of PROK1 and PROKR1 mRNA, respectively. Moreover, E2, acting synergistically with PGE2, increased PROKR1 protein expression. We also evidenced that PROK1\u2013PROKR1 signaling induced expression of following genes and\/or proteins CCN2, CDH13, FGF2, NFATC2, ANGPT1, ANGPT2, CDH1, MUC4, SPP1, IFNG, IL6, LIF, LIFR, TNF, TGFB3, and FGF9, as well as phosphorylation of PTK2 and secretion of IL6 and IL11 by endometrial explants in vitro. Ingenuity pathway analysis revealed that functions associated with the PROK1-regulated genes\/proteins include cell-to-cell contact, cell attachment, migration and viability, differentiation of epithelial tissue, leukocyte migration, inflammatory response, angiogenesis, and vasculogenesis. Summarizing, our study suggests that PROK1 acts pleiotropically as an embryonic signal mediator that regulates endometrial receptivity by increasing the expression of the genes and proteins involved in implantation and pregnancy establishment in pigs.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa181","type":"journal-article","created":{"date-parts":[[2020,9,30]],"date-time":"2020-09-30T10:52:11Z","timestamp":1601463131000},"page":"181-196","source":"Crossref","is-referenced-by-count":14,"title":["Pleiotropic role of prokineticin 1 in the porcine endometrium during pregnancy establishment and embryo implantation \u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Ewelina","family":"Goryszewska","sequence":"first","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Hormonal Action Mechanisms, 10-748 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Piotr","family":"Kaczynski","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Hormonal Action Mechanisms, 10-748 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Baryla","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Hormonal Action Mechanisms, 10-748 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agnieszka","family":"Waclawik","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences, Department of Hormonal Action Mechanisms, 10-748 Olsztyn, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,9,30]]},"reference":[{"key":"2021010605100772700_ref1","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.diff.2013.11.005","article-title":"Pig blastocyst-uterine interactions","volume":"87","author":"Bazer","year":"2014","journal-title":"Differentiation"},{"key":"2021010605100772700_ref2","first-page":"139","article-title":"The ultrastructure of pig trophoblast rransplanted to an ectopic site in the uterine wall","volume":"113","author":"Samuel","year":"1972","journal-title":"J Anat"},{"key":"2021010605100772700_ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1530\/jrf.0.0050001","article-title":"Development of the mouse blastocyst transplanted to the spleen","volume":"5","author":"Kirby","year":"1963","journal-title":"J Reprod 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