{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:38:22Z","timestamp":1790735902596,"version":"4.1.0"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004100"],"award-info":[{"award-number":["2018YFC1004100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2017YFC1001404"],"award-info":[{"award-number":["2017YFC1001404"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,2,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>MicroRNA (miR)-210 is a well-known hypoxia-inducible small RNA. Increasing in vitro evidence demonstrates its involvement in regulating multiple behaviors of placental trophoblasts. However, direct in vivo evidence remains lacking. In the present study, we generated a miR-210-deficient mouse strain using CRISPR\/Cas9 technology, in which miR-210 expression was markedly deficient in various tissues. Little influence on fertility rate and litter size was observed after the deletion of miR-210 in mice. Continuous exposure of pregnant mice to hypoxia (10.5% O2) from E6.5 to E10.5 or to E18.5 led to reduction in fetal weight, and such fetal weight loss was markedly worsened in miR-210-knockout dams. Analysis of the placental structure demonstrated the reduced expansion of placental spongiotrophoblast layer and hampered development of labyrinth fetal blood vessels in knockout mice compared to the wild-type controls upon hypoxia stimulation. The findings indicate that miR-210 participates in regulating placental adaptation to hypoxic stress during pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa187","type":"journal-article","created":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T14:00:04Z","timestamp":1603116004000},"page":"418-429","source":"Crossref","is-referenced-by-count":16,"title":["MicroRNA-210 regulates placental adaptation to maternal hypoxic stress during pregnancy\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Xiaotao","family":"Bian","sequence":"first","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Yang","sequence":"additional","affiliation":[{"name":"NHC Key Lab of Reproduction Regulation, Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlei","family":"Liu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wentong","family":"Jia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences, Wuhan University, Wuhan, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Xia","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Shao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan-Ling","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China"},{"name":"University of Chinese Academy of Sciences, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,10,19]]},"reference":[{"key":"2021021110455780300_ref1","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.molcel.2010.09.022","article-title":"Hypoxia-inducible factors and the response to hypoxic stress","volume":"40","author":"Majmundar","year":"2010","journal-title":"Mol Cell"},{"key":"2021021110455780300_ref2","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/sj.cdd.4402310","article-title":"A microRNA component of the hypoxic response","volume":"15","author":"Kulshreshtha","year":"2008","journal-title":"Cell Death Differ"},{"key":"2021021110455780300_ref3","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/bs.ircmb.2017.03.006","article-title":"Impact of MicroRNAs in the cellular response to hypoxia","volume":"333","author":"Bertero","year":"2017","journal-title":"Int Rev Cell Mol Biol"},{"key":"2021021110455780300_ref4","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1093\/abbs\/gmt141","article-title":"Emerging roles of miR-210 and other non-coding RNAs in the hypoxic response","volume":"46","author":"Huang","year":"2014","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"2021021110455780300_ref5","first-page":"6511","article-title":"MiRNA-210: a current overview","volume":"37","author":"Bavelloni","year":"2017","journal-title":"Anticancer Res"},{"key":"2021021110455780300_ref6","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/iub.427","article-title":"miR-210: more than a silent player in hypoxia","volume":"63","author":"Devlin","year":"2011","journal-title":"IUBMB Life"},{"key":"2021021110455780300_ref7","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.molmed.2010.03.004","article-title":"MiR-210--micromanager of the hypoxia pathway","volume":"16","author":"Huang","year":"2010","journal-title":"Trends Mol Med"},{"key":"2021021110455780300_ref8","doi-asserted-by":"crossref","first-page":"84","DOI":"10.3389\/fphys.2016.00084","article-title":"Elevation of circulating miR-210-3p in high-altitude hypoxic environment","volume":"7","author":"Yan","year":"2016","journal-title":"Front Physiol"},{"key":"2021021110455780300_ref9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.fsi.2018.09.079","article-title":"Potential role for microRNA in facilitating physiological adaptation to hypoxia in the Pacific whiteleg shrimp Litopenaeus vannamei","volume":"84","author":"Wang","year":"2019","journal-title":"Fish Shellfish Immunol"},{"key":"2021021110455780300_ref10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1210\/endo-83-4-701","article-title":"Intrauterine oxygen tension during the estrous cycle in the rat: its relation to uterine respiration and vascular activity","volume":"83","author":"Mitchell","year":"1968","journal-title":"Endocrinology"},{"key":"2021021110455780300_ref11","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1530\/jrf.0.0990673","article-title":"Oxygen tension in the oviduct and uterus of rhesus monkeys, hamsters and rabbits","volume":"99","author":"Fischer","year":"1993","journal-title":"J Reprod Fertil"},{"key":"2021021110455780300_ref12","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.placenta.2012.07.002","article-title":"MIR-210 modulates mitochondrial respiration in placenta with preeclampsia","volume":"33","author":"Muralimanoharan","year":"2012","journal-title":"Placenta"},{"key":"2021021110455780300_ref13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.placenta.2018.03.003","article-title":"Oxidative stress in placental pathology","volume":"69","author":"Schoots","year":"2018","journal-title":"Placenta"},{"key":"2021021110455780300_ref14","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12920-019-0548-x","article-title":"Placental microRNAs in pregnancies with early onset intrauterine growth restriction and preeclampsia: potential impact on gene expression and pathophysiology","volume":"12","author":"Awamleh","year":"2019","journal-title":"BMC Med Genomics"},{"key":"2021021110455780300_ref15","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1582-4934.2011.01291.x","article-title":"Elevated levels of hypoxia-inducible microRNA-210 in pre-eclampsia: new insights into molecular mechanisms for the disease","volume":"16","author":"Zhang","year":"2012","journal-title":"J Cell Mol Med"},{"key":"2021021110455780300_ref16","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1161\/HYPERTENSIONAHA.114.03530","article-title":"MicroRNA-210 contributes to preeclampsia by downregulating potassium channel modulatory factor 1","volume":"64","author":"Luo","year":"2014","journal-title":"Hypertension"},{"key":"2021021110455780300_ref17","doi-asserted-by":"crossref","first-page":"19588","DOI":"10.1038\/srep19588","article-title":"Hypoxia-inducible miR-210 contributes to preeclampsia via targeting thrombospondin type I domain containing 7A","volume":"6","author":"Luo","year":"2016","journal-title":"Sci Rep"},{"key":"2021021110455780300_ref18","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.gene.2016.10.014","article-title":"Evaluation of MicroRNA-210 and protein tyrosine phosphatase, non-receptor type 2 in pre-eclampsia","volume":"596","author":"Adel","year":"2017","journal-title":"Gene"},{"key":"2021021110455780300_ref19","doi-asserted-by":"crossref","first-page":"183","DOI":"10.5114\/aoms.2018.73129","article-title":"Roles of miR-210 in the pathogenesis of pre-eclampsia","volume":"15","author":"Li","year":"2019","journal-title":"Arch Med Sci"},{"key":"2021021110455780300_ref20","doi-asserted-by":"crossref","first-page":"4422","DOI":"10.1111\/jcmm.14335","article-title":"miRNA-210-3p regulates trophoblast proliferation and invasiveness through fibroblast growth factor 1 in selective intrauterine growth restriction","volume":"23","author":"Li","year":"2019","journal-title":"J Cell Mol Med"},{"key":"2021021110455780300_ref21","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1016\/j.ajpath.2011.04.035","article-title":"miR-210 targets iron-sulfur cluster scaffold homologue in human trophoblast cell lines: siderosis of interstitial trophoblasts as a novel pathology of preterm preeclampsia and small-for-gestational-age pregnancies","volume":"179","author":"Lee","year":"2011","journal-title":"Am J Pathol"},{"key":"2021021110455780300_ref22","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1161\/HYPERTENSIONAHA.111.180232","article-title":"Hydroxysteroid (17-beta) dehydrogenase 1 is dysregulated by miR-210 and miR-518c that are aberrantly expressed in preeclamptic placentas: a novel marker for predicting preeclampsia","volume":"59","author":"Ishibashi","year":"2012","journal-title":"Hypertension"},{"key":"2021021110455780300_ref23","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.placenta.2016.09.007","article-title":"Intact feto-placental growth in microRNA-210 deficient mice","volume":"47","author":"Krawczynski","year":"2016","journal-title":"Placenta"},{"key":"2021021110455780300_ref24","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.placenta.2005.01.015","article-title":"How to make a placenta: mechanisms of trophoblast cell differentiation in mice--a review","volume":"26","author":"Cross","year":"2005","journal-title":"Placenta"},{"key":"2021021110455780300_ref25","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S1701-2163(15)30865-3","article-title":"Maternal fetal medicine C. intrauterine growth restriction: screening, diagnosis, and management","volume":"35","author":"Lausman","year":"2013","journal-title":"J Obstet Gynaecol Can"},{"key":"2021021110455780300_ref26","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gad.2.12a.1639","article-title":"Isolation and characterization of a novel trophoblast-specific cDNA in the mouse","volume":"2","author":"Lescisin","year":"1988","journal-title":"Genes Dev"},{"key":"2021021110455780300_ref27","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1002\/mrd.1080340403","article-title":"Progressive expression of trophoblast-specific genes during formation of mouse trophoblast giant cells in vitro","volume":"34","author":"Carney","year":"1993","journal-title":"Mol Reprod Dev"},{"key":"2021021110455780300_ref28","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1242\/dev.104.3.431","article-title":"The localization of laminin mRNA and protein in the postimplantation embryo and placenta of the mouse: an in situ hybridization and immunocytochemical study","volume":"104","author":"Senior","year":"1988","journal-title":"Development"},{"key":"2021021110455780300_ref29","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.mehy.2017.05.007","article-title":"High altitude and pre-eclampsia: adaptation or protection","volume":"104","author":"Ahmed","year":"2017","journal-title":"Med Hypotheses"},{"key":"2021021110455780300_ref30","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.4049\/jimmunol.1301289","article-title":"MiR-210 is induced by Oct-2, regulates B cells, and inhibits autoantibody production","volume":"191","author":"Mok","year":"2013","journal-title":"J Immunol"},{"key":"2021021110455780300_ref31","doi-asserted-by":"crossref","first-page":"695","DOI":"10.15252\/emmm.201404511","article-title":"Genetic and hypoxic alterations of the microRNA-210-ISCU1\/2 axis promote iron-sulfur deficiency and pulmonary hypertension","volume":"7","author":"White","year":"2015","journal-title":"EMBO Mol Med"},{"key":"2021021110455780300_ref32","doi-asserted-by":"crossref","first-page":"e55194","DOI":"10.1371\/journal.pone.0055194","article-title":"Suppression of mitochondrial electron transport chain function in the hypoxic human placenta: a role for miRNA-210 and protein synthesis inhibition","volume":"8","author":"Colleoni","year":"2013","journal-title":"PLoS One"},{"key":"2021021110455780300_ref33","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1113\/JP271057","article-title":"Placental phenotype and resource allocation to fetal growth are modified by the timing and degree of hypoxia during mouse pregnancy","volume":"594","author":"Higgins","year":"2016","journal-title":"J Physiol"},{"key":"2021021110455780300_ref34","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1113\/JP274845","article-title":"Feto- and utero-placental vascular adaptations to chronic maternal hypoxia in the mouse","volume":"596","author":"Cahill","year":"2018","journal-title":"J Physiol"},{"key":"2021021110455780300_ref35","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1113\/jphysiol.2014.272856","article-title":"Mid- to late term hypoxia in the mouse alters placental morphology, glucocorticoid regulatory pathways and nutrient transporters in a sex-specific manner","volume":"592","author":"Cuffe","year":"2014","journal-title":"J Physiol"},{"key":"2021021110455780300_ref36","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1113\/JP271073","article-title":"Morphological and molecular changes in the murine placenta exposed to normobaric hypoxia throughout pregnancy","volume":"594","author":"Matheson","year":"2016","journal-title":"J Physiol"},{"key":"2021021110455780300_ref37","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1432-0436.2006.00103.x","article-title":"Branching morphogenesis during development of placental villi","volume":"74","author":"Cross","year":"2006","journal-title":"Differentiation"},{"key":"2021021110455780300_ref38","doi-asserted-by":"crossref","first-page":"5555","DOI":"10.1210\/jc.2003-030528","article-title":"Overexpression of the soluble vascular endothelial growth factor receptor in preeclamptic patients: pathophysiological consequences","volume":"88","author":"Tsatsaris","year":"2003","journal-title":"J Clin Endocrinol Metab"},{"key":"2021021110455780300_ref39","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1016\/S0002-9440(10)62567-9","article-title":"Vascular endothelial growth factor ligands and receptors that regulate human cytotrophoblast survival are dysregulated in severe preeclampsia and hemolysis, elevated liver enzymes, and low platelets syndrome","volume":"160","author":"Zhou","year":"2002","journal-title":"Am J Pathol"},{"key":"2021021110455780300_ref40","doi-asserted-by":"crossref","first-page":"15878","DOI":"10.1074\/jbc.M800731200","article-title":"MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3","volume":"283","author":"Fasanaro","year":"2008","journal-title":"J Biol Chem"},{"key":"2021021110455780300_ref41","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.placenta.2011.04.018","article-title":"Expression patterns of notch receptors and their ligands jagged and delta in human placenta","volume":"32","author":"Herr","year":"2011","journal-title":"Placenta"},{"key":"2021021110455780300_ref42","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1582-4934.2011.01370.x","article-title":"MiR-210: an important player in the pathogenesis of preeclampsia?","volume":"16","author":"Liu","year":"2012","journal-title":"J Cell Mol Med"},{"key":"2021021110455780300_ref43","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11010-012-1396-6","article-title":"miR-210 activates notch signaling pathway in angiogenesis induced by cerebral ischemia","volume":"370","author":"Lou","year":"2012","journal-title":"Mol Cell Biochem"},{"key":"2021021110455780300_ref44","first-page":"560","article-title":"Wang YL. A positive feedback self-regulatory loop between miR-210 and HIF-1alpha mediated by CPEB2 is involved in trophoblast syncytialization: implication of trophoblast malfunction in preeclampsiadagger","volume":"102","author":"Wang","year":"2020","journal-title":"Biol Reprod"},{"key":"2021021110455780300_ref45","doi-asserted-by":"crossref","first-page":"35134","DOI":"10.1074\/jbc.M109.052779","article-title":"An integrated approach for experimental target identification of hypoxia-induced miR-210","volume":"284","author":"Fasanaro","year":"2009","journal-title":"J Biol Chem"},{"key":"2021021110455780300_ref46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/ijc.24687","article-title":"Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survival","volume":"126","author":"Greither","year":"2010","journal-title":"Int J Cancer"},{"key":"2021021110455780300_ref47","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.molcel.2009.09.006","article-title":"Hypoxia-inducible mir-210 regulates normoxic gene expression involved in tumor initiation","volume":"35","author":"Huang","year":"2009","journal-title":"Mol Cell"},{"key":"2021021110455780300_ref48","doi-asserted-by":"crossref","first-page":"2553","DOI":"10.3892\/or.2016.5129","article-title":"MicroRNA-210 promotes cancer angiogenesis by targeting fibroblast growth factor receptor-like 1 in hepatocellular carcinoma","volume":"36","author":"Yang","year":"2016","journal-title":"Oncol Rep"},{"key":"2021021110455780300_ref49","doi-asserted-by":"crossref","first-page":"S124","DOI":"10.1161\/CIRCULATIONAHA.109.928424","article-title":"MicroRNA-210 as a novel therapy for treatment of ischemic heart disease","volume":"122","author":"Hu","year":"2010","journal-title":"Circulation"},{"key":"2021021110455780300_ref50","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1038\/s41598-019-39426-5","article-title":"Trophoblast-specific expression of Hif-1alpha results in preeclampsia-like symptoms and fetal growth restriction","volume":"9","author":"Albers","year":"2019","journal-title":"Sci Rep"},{"key":"2021021110455780300_ref51","doi-asserted-by":"crossref","first-page":"R844","DOI":"10.1152\/ajpregu.00237.2005","article-title":"Preserved placental oxygenation and development during severe systemic hypoxia","volume":"290","author":"Sch\u00e4ffer","year":"2006","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"2021021110455780300_ref52","doi-asserted-by":"crossref","first-page":"10479","DOI":"10.1128\/MCB.25.23.10479-10491.2005","article-title":"Hypoxia-inducible factors 1alpha and 2alpha regulate trophoblast differentiation","volume":"25","author":"Cowden Dahl","year":"2005","journal-title":"Mol Cell Biol"},{"key":"2021021110455780300_ref53","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1053\/plac.2002.0858","article-title":"Placental composition and surface area but not vascularization are altered by maternal protein restriction in the rat","volume":"24","author":"Doherty","year":"2003","journal-title":"Placenta"},{"key":"2021021110455780300_ref54","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.ydbio.2007.12.007","article-title":"Maternal hypoxia activates endovascular trophoblast cell invasion","volume":"314","author":"Rosario","year":"2008","journal-title":"Dev Biol"},{"key":"2021021110455780300_ref55","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1095\/biolreprod.115.138032","article-title":"A prolactin family paralog regulates placental adaptations to a physiological stressor","volume":"94","author":"Bu","year":"2016","journal-title":"Biol Reprod"},{"key":"2021021110455780300_ref56","doi-asserted-by":"crossref","first-page":"E7212","DOI":"10.1073\/pnas.1612626113","article-title":"HIF-KDM3A-MMP12 regulatory circuit ensures trophoblast plasticity and placental adaptations to hypoxia","volume":"113","author":"Chakraborty","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021021110455780300_ref57","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1095\/biolreprod65.6.1813","article-title":"Placentomegaly in cloned mouse concepti caused by expansion of the spongiotrophoblast layer","volume":"65","author":"Tanaka","year":"2001","journal-title":"Biol Reprod"},{"key":"2021021110455780300_ref58","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.placenta.2008.05.008","article-title":"Ultrastructure of placental hyperplasia in mice: comparison of placental phenotypes with three different etiologies","volume":"29","author":"Wakisaka","year":"2008","journal-title":"Placenta"},{"key":"2021021110455780300_ref59","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1095\/biolreprod.115.133454","article-title":"Lentiviral vector-mediated complementation restored fetal viability but not placental hyperplasia in Plac1-deficient mice","volume":"94","author":"Muto","year":"2016","journal-title":"Biol Reprod"},{"key":"2021021110455780300_ref60","doi-asserted-by":"crossref","first-page":"7490","DOI":"10.1073\/pnas.122039999","article-title":"Placental overgrowth in mice lacking the imprinted gene Ipl","volume":"99","author":"Frank","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2021021110455780300_ref61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ydbio.2019.01.019","article-title":"miR-126 regulates glycogen trophoblast proliferation and DNA methylation in the murine placenta","volume":"449","author":"Sharma","year":"2019","journal-title":"Dev Biol"},{"key":"2021021110455780300_ref62","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/mrd.23148","article-title":"Deletion of Prl7d1 causes placental defects at mid-pregnancy in mice","volume":"86","author":"Zhang","year":"2019","journal-title":"Mol Reprod Dev"},{"key":"2021021110455780300_ref63","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1387\/ijdb.082768dh","article-title":"Development and function of trophoblast giant cells in the rodent placenta","volume":"54","author":"Hu","year":"2010","journal-title":"Int J Dev Biol"},{"key":"2021021110455780300_ref64","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/35080570","article-title":"Placental development: lessons from mouse mutants","volume":"2","author":"Rossant","year":"2001","journal-title":"Nat Rev Genet"},{"key":"2021021110455780300_ref65","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0143-4004(96)90051-X","article-title":"Differentiation of trophoblast endocrine cells","volume":"17","author":"Soares","year":"1996","journal-title":"Placenta"},{"key":"2021021110455780300_ref66","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.ydbio.2005.05.010","article-title":"Determinants of trophoblast lineage and cell subtype specification in the mouse placenta","volume":"284","author":"Simmons","year":"2005","journal-title":"Dev Biol"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioaa187\/34447824\/ioaa187.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/104\/2\/418\/36234184\/ioaa187.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/biolreprod\/article-pdf\/104\/2\/418\/36234184\/ioaa187.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T02:47:27Z","timestamp":1723776447000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/104\/2\/418\/5930364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,19]]},"references-count":66,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2020,10,19]]},"published-print":{"date-parts":[[2021,2,11]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioaa187","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,2]]},"published":{"date-parts":[[2020,10,19]]}}}