{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T18:37:28Z","timestamp":1788028648126,"version":"build-2784847793"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,8]],"date-time":"2020-12-08T00:00:00Z","timestamp":1607385600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004400"],"award-info":[{"award-number":["2018YFC1004400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31771664"],"award-info":[{"award-number":["31771664"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["R01 HD042280"],"award-info":[{"award-number":["R01 HD042280"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The endometrium undergoes a pregnancy-delivery-repair cycle multiple times during the reproductive lifespan in females. Decidualization is one of the critical events for the success of this essential process. We have previously reported that Notch1 is essential for artificial decidualization in mice. However, in a natural pregnancy, the deletion of Notch1 (PgrCre\/+Notch1f\/f, or Notch1d\/d) only affects female fertility in the first 30\u00a0days of a 6-month fertility test, but not the later stages. In the present study, we undertook a closer evaluation at the first pregnancy of these mice to attempt to understand this puzzling phenomenon. We observed a large number of pregnancy losses in Notch1d\/d mice in their first pregnancy, which led to the subfertility observed in the first 30\u00a0days of the fertility test. We then demonstrated that the initial pregnancy loss is a consequence of impaired decidualization. Furthermore, we identified a group of genes that contribute to Notch1 regulated decidualization in a natural pregnancy. Gene ontogeny analysis showed that these differentially expressed genes in the natural pregnancy are involved in cell\u2013cell and cell\u2013matrix interactions, different from genes that have been previously identified from the artificial decidualization model, which contribute to cell proliferation and apoptosis. In summary, we determined that Notch1 is essential for normal decidualization in the mouse uterus only in the first pregnancy but not in subsequent ones.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa222","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T12:25:22Z","timestamp":1607516722000},"page":"539-547","source":"Crossref","is-referenced-by-count":10,"title":["Notch1 is crucial for decidualization and maintaining the first pregnancy in the mouse\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Yao","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Peng","family":"He","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke-zhi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Wen","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgerally T","family":"Fazleabas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Biology, Michigan State University, Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ren-Wei","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, College of Veterinary Medicine, South China Agricultural University, Guangzhou, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,12,8]]},"reference":[{"key":"2021031607215383500_ref1","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/nm.3012","article-title":"Mechanisms of implantation: strategies for successful pregnancy","volume":"18","author":"Cha","year":"2012","journal-title":"Nat Med"},{"key":"2021031607215383500_ref2","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/978-3-319-15856-3_10","article-title":"Implantation 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