{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:57:43Z","timestamp":1793393863420,"version":"4.5.0"},"reference-count":110,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T00:00:00Z","timestamp":1608163200000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","award":["1022068"],"award-info":[{"award-number":["1022068"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,3,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Bovine endometrium consists of epithelial and stromal cells that respond to conceptus interferon tau (IFNT), the maternal recognition of pregnancy (MRP) signal, by increasing expression of IFN-stimulated genes (ISGs). Endometrial epithelial and stromal-cell-specific ISGs are largely unknown but hypothesized to have essential functions during pregnancy establishment. Bovine endometrial epithelial cells were cultured in inserts above stromal fibroblast (SF) cells for 6\u00a0h in medium alone or with IFNT. The epithelial and SF transcriptomic response was analyzed separately using RNA sequencing and compared to a list of 369 DEGs recently identified in intact bovine endometrium in response to elongating bovine conceptuses and IFNT. Bovine endometrial epithelial and SF shared 223 and 70 DEGs in common with the list of 369 endometrial DEGs. Well-known ISGs identified in the epithelial and SF were ISG15, MX1, MX2, and OAS2. DEGs identified in the epithelial but not SF included a number of IRF molecules (IRF1, IRF2, IRF3, and IRF8), mitochondria SLC transporters (SLC25A19, SLC25A28, and SLC25A30), and a ghrelin receptor. Expression of ZC3HAV1, an anti-retroviral gene, increased specifically within the SF. Gene ontology analysis identified the type I IFN signaling pathway and activation of nuclear factor kappa B transcription factors as biological processes associated with the epithelial cell DEGs. This study has identified biologically relevant IFNT-stimulated genes within specific endometrial cell types. The findings provide critical information regarding the effects of conceptus IFNT on specific endometrial compartments during early developmental processes in cattle.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa226","type":"journal-article","created":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T19:15:11Z","timestamp":1608318911000},"page":"669-683","source":"Crossref","is-referenced-by-count":34,"title":["Conceptus-induced, interferon tau-dependent gene expression in bovine endometrial epithelial and stromal cells\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Heather L","family":"Chaney","sequence":"first","affiliation":[{"name":"Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lindsay F","family":"Grose","sequence":"additional","affiliation":[{"name":"Division of Animal and Nutritional Sciences, West Virginia University, Morgantown, WV, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Charpigny","sequence":"additional","affiliation":[{"name":"INRA, Biologie du D\u00e9veloppement et Reproduction, Jouy en Josas, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanta K","family":"Behura","sequence":"additional","affiliation":[{"name":"Division of Animal Sciences, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I Martin","family":"Sheldon","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Swansea University, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James G","family":"Cronin","sequence":"additional","affiliation":[{"name":"Swansea University Medical School, Swansea University, Swansea, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Lonergan","sequence":"additional","affiliation":[{"name":"School 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