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Estradiol-17\u03b2 (E2) is the primary embryonic signal in the pig, and its importance has been questioned recently. However, E2 is not the only molecule of embryonic origin. In pigs, prostaglandin E2 (PGE2) is abundantly synthesized and secreted by conceptuses and endometrium. The present study aimed to determine the role of PGE2 and its simultaneous action with E2 in changes in porcine endometrial transcriptome during pregnancy establishment. The effects of PGE2 and PGE2 acting with E2 were studied using an in vivo model of intrauterine hormone infusions, and were compared to the effects of E2 alone and conceptuses\u2019 presence on day 12 of pregnancy. The endometrial transcriptome was profiled using gene expression microarrays followed by statistical analyses. Downstream analyses were performed using bioinformatics tools. Differential expression of selected genes was verified by quantitative polymerase chain reaction. Microarray analysis revealed 2413 differentially expressed genes (DEGs) in the endometrium treated simultaneously with PGE2 and E2 (P\u00a0&amp;lt;\u00a00.01). No significant effect of PGE2 administered alone on endometrial transcriptome was detected. Gene ontology annotations enriched for DEGs were related to multiple processes such as: focal adhesion, vascularization, cell migration and proliferation, glucose metabolism, tissue remodeling, and activation of immune response. Simultaneous administration of E2 and PGE2 induced more changes within endometrial transcriptome characteristic to pregnancy than infusion of E2 alone. The present findings suggest that synergistic action of estradiol-17\u03b2 and PGE2 resembles the effects of pregnancy on endometrial transcriptome better than E2 alone.<\/jats:p>","DOI":"10.1093\/biolre\/ioaa230","type":"journal-article","created":{"date-parts":[[2020,12,23]],"date-time":"2020-12-23T02:09:42Z","timestamp":1608689382000},"page":"818-834","source":"Crossref","is-referenced-by-count":14,"title":["Synergistic action of estradiol and PGE2 on endometrial transcriptome in vivo resembles pregnancy effects better than estradiol alone\u2020"],"prefix":"10.1093","volume":"104","author":[{"given":"Piotr","family":"Kaczynski","sequence":"first","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefan","family":"Bauersachs","sequence":"additional","affiliation":[{"name":"Vetsuisse Faculty, Institute of Veterinary Anatomy, Functional Genomics, University of Zurich, Zurich, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ewelina","family":"Goryszewska","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monika","family":"Baryla","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agnieszka","family":"Waclawik","sequence":"additional","affiliation":[{"name":"Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, 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