{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T11:49:03Z","timestamp":1790768943794,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,3,9]],"date-time":"2021-03-09T00:00:00Z","timestamp":1615248000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000521","name":"Canadian Cancer Society","doi-asserted-by":"publisher","award":["#704793"],"award-info":[{"award-number":["#704793"]}],"id":[{"id":"10.13039\/501100000521","id-type":"DOI","asserted-by":"publisher"}]},{"name":"CCS innovation to Impact","award":["#706320"],"award-info":[{"award-number":["#706320"]}]},{"name":"Cancer Research Society Operation","award":["#23237"],"award-info":[{"award-number":["#23237"]}]},{"name":"Centre for Research in Reproductuion and Development"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,6,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The oviduct\/fallopian tube is a tube-like structure that extends from the uterus to the ovary. It is an essential reproductive organ that provides an environment for internal fertilization and preimplantation development. However, our knowledge of its regional and cellular heterogeneity is still limited. Here, we examined the anatomical complexity of mouse oviducts using modern imaging techniques and fluorescence reporter lines. We found that there are consistent coiling patterns and turning points in the coiled mouse oviduct that serve as reliable landmarks for luminal morphological regionalities. We also found previously unrecognized anatomical structures in the isthmus and uterotubal junction, which likely play roles in reproduction. Furthermore, we demarcated the ampulla\u2013isthmus junction as a distinct region. Taken together, the oviduct mucosal epithelium has highly diverse structures with distinct epithelial cell populations, reflecting its complex functions in reproduction.<\/jats:p>","DOI":"10.1093\/biolre\/ioab043","type":"journal-article","created":{"date-parts":[[2021,3,11]],"date-time":"2021-03-11T05:20:26Z","timestamp":1615440026000},"page":"1249-1261","source":"Crossref","is-referenced-by-count":49,"title":["Anatomical and cellular heterogeneity in the mouse oviduct\u2014its potential roles in reproduction and preimplantation development"],"prefix":"10.1093","volume":"104","author":[{"given":"Keerthana","family":"Harwalkar","sequence":"first","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew J","family":"Ford","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie","family":"Teng","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada"},{"name":"Department of Human Genetics, McGill University, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuko","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenna","family":"Yang","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman Cancer Research Centre, Montreal, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingo","family":"Burtscher","sequence":"additional","affiliation":[{"name":"Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Munich, Germany"},{"name":"Institute of Stem Cell Research, Helmholtz Center, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heiko","family":"Lickert","sequence":"additional","affiliation":[{"name":"Institute of Diabetes and Regeneration Research, Helmholtz Diabetes Center, Helmholtz Center Munich, Munich, Germany"},{"name":"Institute of Stem Cell Research, Helmholtz Center, Munich, Germany"},{"name":"German Centre for Diabetes Research (DZD), Munich, Germany"},{"name":"Department of Medicine, Technical University of Munich, Munich, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yojiro","family":"Yamanaka","sequence":"additional","affiliation":[{"name":"Rosalind and Morris Goodman 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Sox17-mCherry fusion mouse line allows visualization of endoderm and vascular endothelial development","volume":"50","author":"Burtscher","year":"2012","journal-title":"Genesis"},{"key":"2021060706380112800_ref40","first-page":"4","article-title":"Performing vaginal lavage, crystal violet staining, and vaginal cytological evaluation for mouse estrous cycle staging identification","volume":"67","author":"McLean","year":"2012","journal-title":"J Vis Exp"},{"key":"2021060706380112800_ref41","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1242\/dev.144386","article-title":"Insights from imaging the implanting embryo and the uterine environment in three dimensions","volume":"143","author":"Arora","year":"2016","journal-title":"Development"},{"key":"2021060706380112800_ref42","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.proghi.2016.04.001","article-title":"A survey of clearing techniques for 3D imaging of tissues with special reference to connective 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