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Metabolic abnormalities such as hyperinsulinemia, insulin resistance, cardiovascular complications, dyslipidemia, and obesity are frequently present in PCOS women. Several key pathogenic pathways overlap between these metabolic abnormalities, notably chronic inflammation. The observation that this mechanism was shared led to the hypothesis that a chronic inflammatory state could contribute to the pathogenesis of PCOS. Moreover, while physiological inflammation is an essential feature of reproductive events such as ovulation, menstruation, implantation, and labor at term, the establishment of chronic inflammation may be a pivotal feature of the observed reproductive dysfunctions in PCOS women. Taken together, the present work aims to review the available evidence about inflammatory mediators and related mechanisms in women with PCOS, with an emphasis on reproductive function.<\/jats:p>","DOI":"10.1093\/biolre\/ioab050","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T07:56:11Z","timestamp":1616140571000},"page":"1205-1217","source":"Crossref","is-referenced-by-count":119,"title":["Inflammation and reproductive function in women with polycystic ovary syndrome"],"prefix":"10.1093","volume":"104","author":[{"given":"Leandro M","family":"Velez","sequence":"first","affiliation":[{"name":"Department of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Seldin","sequence":"additional","affiliation":[{"name":"Department of Biological Chemistry, Center for Epigenetics and Metabolism, University of California, Irvine, CA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia B","family":"Motta","sequence":"additional","affiliation":[{"name":"Center of Pharmacological and Botanical Studies (CEFYBO), National Scientific and Technical Research Council, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"key":"2022012416274483000_ref1","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1017\/S0954422416000287","article-title":"Metabolic consequences of obesity and insulin resistance in polycystic ovary syndrome: diagnostic and methodological challenges","volume":"30","author":"Jeanes","year":"2017","journal-title":"Nutr Res Rev"},{"key":"2022012416274483000_ref2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.bpobgyn.2016.03.009","article-title":"Diagnostic criteria for PCOS: Is there a need for a 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