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One of the main steps that ensures successful fertilization is acrosome reaction. The acrosome, a special kind of organelle with a cap-like structure that covers the anterior portion of sperm head, plays a key role in the process. Acrosome biogenesis begins with the initial stage of spermatid development, and it is typically divided into four successive phases: the Golgi phase, cap phase, acrosome phase, and maturation phase. The run smoothly of above processes needs an active and specific coordination between the all kinds of organelles (endoplasmic reticulum, trans-Golgi network, and nucleus) and cytoplasmic structures (acroplaxome and manchette). During the past two decades, an increasing number of genes have been discovered to be involved in modulating acrosome formation. Most of these proteins interact with each other and show a complicated molecular regulatory mechanism to facilitate the occurrence of this event. This review focuses on the progresses of studying acrosome biogenesis using gene-manipulated mice and highlights an emerging molecular basis of mammalian acrosome formation.<\/jats:p>","DOI":"10.1093\/biolre\/ioab117","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T01:43:13Z","timestamp":1623807793000},"page":"789-807","source":"Crossref","is-referenced-by-count":37,"title":["The molecular mechanisms underlying acrosome biogenesis elucidated by gene-manipulated mice\u2020"],"prefix":"10.1093","volume":"105","author":[{"given":"Wenfeng","family":"Xiong","sequence":"first","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunling","family":"Shen","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhugang","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Medical Genomics, Research Center for Experimental Medicine, Rui-Jin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"2021101306343191800_ref1","doi-asserted-by":"crossref","first-page":"646","DOI":"10.4103\/1008-682X.153299","article-title":"Mechanisms of fertilization elucidated by gene-manipulated animals","volume":"17","author":"Okabe","year":"2015","journal-title":"Asian J Androl"},{"key":"2021101306343191800_ref2","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1172\/JCI41585","article-title":"Fertilization: a sperm's journey to and interaction with the oocyte","volume":"120","author":"Ikawa","year":"2010","journal-title":"J Clin Invest"},{"key":"2021101306343191800_ref3","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.gyobfe.2009.04.009","article-title":"Role of the female environment in sperm capacitation","volume":"37","author":"Patrat","year":"2009","journal-title":"Gynecol Obstet 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