{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T21:25:37Z","timestamp":1790803537702,"version":"4.1.0"},"reference-count":70,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T00:00:00Z","timestamp":1624492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Secreted phosphoprotein 1 (SPP1, also known as osteopontin) binds integrins to mediate cell\u2013cell and cell\u2013extracellular matrix communication to promote cell adhesion, migration, and differentiation. Considerable evidence links SPP1 to pregnancy in several species. Current evidence suggests that SPP1 is involved in implantation and placentation in mice, but in vivo localization of SPP1 and in vivo mechanistic studies to substantiate these roles are incomplete and contradictory. We localized Spp1 mRNA and protein in the endometrium and placenta of mice throughout gestation, and utilized delayed implantation of mouse blastocysts to link SPP1 expression to the implantation chamber. Spp1 mRNA and protein localized to the endometrial luminal (LE), but not glandular epithelia (GE) in interimplantation regions of the uterus throughout gestation. Spp1 mRNA and protein also localized to uterine naturel killer (uNK) cells of the decidua. Within the implantation chamber, Spp1 mRNA localized only to intermittent LE cells, and to the inner cell mass. SPP1 protein localized to intermittent trophoblast cells, and to the parietal endoderm. These results suggest that SPP1: (1) is secreted by the LE at interimplantation sites for closure of the uterine lumen to form the implantation chamber; (2) is secreted by LE adjacent to the attaching trophoblast cells for attachment and invasion of the blastocyst; and (3) is not a component of histotroph secreted from the GE, but is secreted from uNK cells in the decidua to increase angiogenesis within the decidua to augment hemotrophic support of embryonic\/fetal development of the conceptus.<\/jats:p>","DOI":"10.1093\/biolre\/ioab125","type":"journal-article","created":{"date-parts":[[2021,6,24]],"date-time":"2021-06-24T08:28:51Z","timestamp":1624523331000},"page":"892-904","source":"Crossref","is-referenced-by-count":31,"title":["SPP1 expression in the mouse uterus and placenta: implications for implantation\u2020"],"prefix":"10.1093","volume":"105","author":[{"given":"Avery C","family":"Kramer","sequence":"first","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W","family":"Erikson","sequence":"additional","affiliation":[{"name":"Endocrine Technologies Core, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan A","family":"McLendon","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanako","family":"Hayashi","sequence":"additional","affiliation":[{"name":"School of Molecular Biosciences, Washington State University, Pullman, WA, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Spencer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, University of Missouri, Columbia, MO, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert C","family":"Burghardt","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, College of Veterinary Medicine and Biomedical Sciences, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,24]]},"reference":[{"key":"2021101306361111300_ref1","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1096\/fasebj.7.15.8262332","article-title":"Osteopontin: a protein with diverse functions","volume":"7","author":"Denhardt","year":"1993","journal-title":"FASEB J."},{"key":"2021101306361111300_ref2","author":"Butler"},{"key":"2021101306361111300_ref3","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1177\/10454411000110030101","article-title":"Osteopontin","volume":"11","author":"Sodek","year":"2000","journal-title":"Crit Rev Oral Biol Med."},{"key":"2021101306361111300_ref4","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1095\/biolreprod.103.020651","article-title":"Osteopontin: roles in implantation and placentation","volume":"69","author":"Johnson","year":"2003","journal-title":"Biol Reprod."},{"key":"2021101306361111300_ref5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1083\/jcb.106.2.441","article-title":"Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization","volume":"106","author":"Nomura","year":"1988","journal-title":"J Cell Biol."},{"key":"2021101306361111300_ref6","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1091\/mbc.3.10.1169","article-title":"Expression and distribution of osteopontin in human tissues: widespread association with luminal epithelial surfaces","volume":"3","author":"Brown","year":"1992","journal-title":"Mol Biol Cell."},{"key":"2021101306361111300_ref7","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1095\/biolreprod61.4.884","article-title":"Ovine osteopontin: I. 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