{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:36:53Z","timestamp":1792633013115,"version":"4.5.0"},"reference-count":79,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T00:00:00Z","timestamp":1632355200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Philippine Council for Health Research and Development, Department of Science and Technology","award":["5R01HD10072902"],"award-info":[{"award-number":["5R01HD10072902"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Fetal cell-derived exosomes promote inflammation in uterine and cervical cells to promote labor and delivery. However, the effect of maternal exosomes on fetal cells is still not known. We tested the hypothesis that cervical cells exposed to infectious and oxidative stress (OS) signals produce exosomes that can induce inflammation at the feto-maternal interface (FMi). Exosomes isolated from medium samples from human ectocervical epithelial cells (ecto), endocervical epithelial cells (endo), and cervical stromal cells (stroma) in normal cell culture (control) or exposed to infection or OS conditions were characterized based on morphology, size, quantity, expression of tetraspanin markers, and cargo proteins. Human decidual cells, chorion trophoblast cells (CTC), chorion mesenchymal cells (CMC), amnion mesenchymal cells (AMC), and amnion epithelial cells (AEC) were treated with control, LPS-, or OS-treated cervical exosomes. Enzyme-linked immunosorbent assay for pro-inflammatory cytokines and progesterone was done to determine the recipient cells\u2019 inflammatory status. Ecto, endo, and stroma released \u223c110\u00a0nm, cup-shaped exosomes. LPS and OS treatments did not affect exosome size; however, OS significantly increased the number of exosomes released by all cervical cells. Cervical exosomes were detected by fluorescence microscopy in each target cell after treatment. Exosomes from LPS- and CSE-treated cervical cells increased the inflammatory cytokine levels in the decidual cells, CMC, AMC, and AEC. LPS-treated stromal cell exosomes increased IL-6, IL-8, and progesterone in CTC. In conclusion, infection and OS can produce inflammatory cargo-enriched cervical exosomes that can destabilize FMi cells. However, the refractoriness of CTC to exosome treatments suggests a barrier function of the chorion at the FMi.<\/jats:p>","DOI":"10.1093\/biolre\/ioab181","type":"journal-article","created":{"date-parts":[[2021,9,23]],"date-time":"2021-09-23T12:42:21Z","timestamp":1632400941000},"page":"1562-1576","source":"Crossref","is-referenced-by-count":21,"title":["Cross talk: trafficking and functional impact of maternal exosomes at the feto-maternal interface under normal and pathologic states"],"prefix":"10.1093","volume":"105","author":[{"given":"Ourlad Alzeus G","family":"Tantengco","sequence":"first","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"},{"name":"Department of Biochemistry and Molecular Biology, College of Medicine, University of the Philippines Manila, Manila, Philippines"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enkhtuya","family":"Radnaa","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hend","family":"Shahin","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talar","family":"Kechichian","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramkumar","family":"Menon","sequence":"additional","affiliation":[{"name":"Division of Maternal-Fetal Medicine and Perinatal Research, Department of Obstetrics and Gynecology, The University of Texas Medical Branch at Galveston, Galveston, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,9,23]]},"reference":[{"key":"2021122108173041500_ref1","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1053\/j.semperi.2017.07.014","article-title":"The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: Where are we now?","volume":"41","author":"Vink","year":"2017","journal-title":"Semin Perinatol"},{"key":"2021122108173041500_ref2","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1016\/j.jbiomech.2015.02.065","article-title":"The mechanical role of the cervix in 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