{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T20:00:59Z","timestamp":1785182459374,"version":"3.55.0"},"reference-count":116,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,10,23]],"date-time":"2021-10-23T00:00:00Z","timestamp":1634947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HHSN275201300006C"],"award-info":[{"award-number":["HHSN275201300006C"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,1,13]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The complex physiologic process of parturition includes the onset of labor, which requires the orchestrated stimulation of a common pathway involving uterine contractility, cervical ripening, and chorioamniotic membrane activation. However, the labor-specific processes taking place in these tissues have limited use as predictive biomarkers unless they can be probed in non-invasive samples, such as the peripheral blood. Herein, we utilized a transcriptomic dataset to assess labor-specific changes in the peripheral blood of women who delivered at term. We identified a set of genes that were differentially expressed with labor and enriched for immunological processes, and these gene expression changes were strongly correlated with results from prior studies, providing in silico validation of our findings. We then identified significant correlations between labor-specific transcriptomic changes in the maternal circulation and those detected in the chorioamniotic membranes, myometrium, and cervix of women at term, demonstrating that tissue-specific labor signatures are partly mirrored in the peripheral blood. Finally, we demonstrated a significant overlap between the peripheral blood transcriptomic changes in term parturition and those observed in asymptomatic women, prior to the diagnosis of preterm prelabor rupture of the membranes, who ultimately delivered preterm. Collectively, we provide evidence that the normal process of labor at term is characterized by a unique immunological expression signature, which may serve as a useful tool for assessing labor status and for potentially identifying women at risk for preterm birth.<\/jats:p>","DOI":"10.1093\/biolre\/ioab197","type":"journal-article","created":{"date-parts":[[2021,12,6]],"date-time":"2021-12-06T19:09:12Z","timestamp":1638817752000},"page":"185-199","source":"Crossref","is-referenced-by-count":29,"title":["Transcriptome changes in maternal peripheral blood during term parturition mimic perturbations preceding spontaneous preterm birth"],"prefix":"10.1093","volume":"106","author":[{"given":"Nardhy","family":"Gomez-Lopez","sequence":"first","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"},{"name":"Department of Biochemistry, Microbiology, and Immunology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Romero","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, USA"},{"name":"Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, MI, USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA"},{"name":"Detroit Medical Center, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose","family":"Galaz","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaurav","family":"Bhatti","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Done","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derek","family":"Miller","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corina","family":"Ghita","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichiro","family":"Motomura","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Farias-Jofre","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunjung","family":"Jung","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Pique-Regi","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, Division of Obstetrics and Maternal-Fetal Medicine, Division of Intramural Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, U.S. Department of Health and Human Services (NICHD\/NIH\/DHHS), Bethesda, MD, and Detroit, MI, USA"},{"name":"Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia S","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Wayne State University School of Medicine, Detroit, MI, USA"},{"name":"Office of Women\u2019s Health, Integrative Biosciences Center, Wayne State University, Detroit, MI, USA"},{"name":"Department of Physiology, Wayne State University School of Medicine, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tinnakorn","family":"Chaiworapongsa","sequence":"additional","affiliation":[{"name":"Perinatology Research Branch, 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USA"},{"name":"Department of Computer Science, Wayne State University College of Engineering, Detroit, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,10,23]]},"reference":[{"key":"2022030514290047100_ref1","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/nm0595-460","article-title":"A placental clock controlling the length of human pregnancy","volume":"1","author":"McLean","year":"1995","journal-title":"Nat Med"},{"key":"2022030514290047100_ref2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJMra061360","article-title":"Parturition","volume":"356","author":"Smith","year":"2007","journal-title":"N Engl J Med"},{"key":"2022030514290047100_ref3","volume-title":"Williams Obstetrics","author":"Cunningham","year":"2018","edition":"25th"},{"key":"2022030514290047100_ref4","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1749-6632.1994.tb21771.x","article-title":"The 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