{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T20:35:03Z","timestamp":1772138103439,"version":"3.50.1"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T00:00:00Z","timestamp":1638835200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Infertility represents a growing burden worldwide, with one in seven couples presenting difficulties conceiving. Among these, 10\u201315% of the men have idiopathic infertility that does not correlate with any defect in the classical sperm parameters measured. In the present study, we used a mouse model to investigate the effects of maternal undernutrition on fertility in male progeny. Our results indicate that mothers fed on a low-protein diet during gestation and lactation produce male offspring with normal sperm morphology, concentration, and motility but exhibiting an overall decrease of fertility when they reach adulthood. Particularly, in contrast to control, sperm from these offspring show a remarkable lower capacity to fertilize oocytes when copulation occurs early in the estrus cycle relative to ovulation, due to an altered sperm capacitation. Our data demonstrate for the first time that maternal nutritional stress can have long-term consequences on the reproductive health of male progeny by affecting sperm physiology, especially capacitation, with no observable impact on spermatogenesis and classical quantitative and qualitative sperm parameters. Moreover, our experimental model could be of major interest to study, explain, and ultimately treat certain categories of infertilities.<\/jats:p>","DOI":"10.1093\/biolre\/ioab222","type":"journal-article","created":{"date-parts":[[2021,12,7]],"date-time":"2021-12-07T14:06:31Z","timestamp":1638885991000},"page":"463-476","source":"Crossref","is-referenced-by-count":1,"title":["When idiopathic male infertility is rooted in maternal malnutrition during the perinatal period in mice"],"prefix":"10.1093","volume":"106","author":[{"given":"Yuki","family":"Muranishi","sequence":"first","affiliation":[{"name":"Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, UMR1019, Clermont-Ferrand, France"},{"name":"Department of Life and Food Sciences, Obihiro University of Agriculture and Veterinary Medicine, Obihiro, Hokkaido, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurent","family":"Parry","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, UMR1019, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e9lanie","family":"Vachette-Dit-Martin","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, UMR1019, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Saez","sequence":"additional","affiliation":[{"name":"INSERM U1103, Universit\u00e9 Clermont Auvergne, CNRS UMR-6293, Institute Genetic, Reproduction and Development, Team-Mechanisms of post-testicular Infertility, Clermont-Ferrand, 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Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00e9my","family":"Tournayre","sequence":"additional","affiliation":[{"name":"Unit\u00e9 de Nutrition Humaine, INRAE, Universit\u00e9 Clermont Auvergne, UMR1019, Clermont-Ferrand, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serge","family":"Bottari","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Carpentiero","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"},{"name":"Institute for Advanced Biosciences INSERM U1209, CNRS UMR5309, Grenoble, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guillaume","family":"Martinez","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Grenoble Alpes, Grenoble, France"},{"name":"Institute for Advanced Biosciences 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