{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T08:35:14Z","timestamp":1793090114297,"version":"4.5.0"},"reference-count":148,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["2R01HD082208"],"award-info":[{"award-number":["2R01HD082208"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD45787"],"award-info":[{"award-number":["R01HD45787"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P51OD011092"],"award-info":[{"award-number":["P51OD011092"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,2,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In vitro follicle development (IVFD) is an adequate model to obtain basic knowledge of folliculogenesis and provides a tool for ovarian toxicity screening. IVFD yielding competent oocytes may also offer an option for fertility and species preservation. To promote follicle growth and oocyte maturation in vitro, various culture systems are utilized for IVFD in rodents, domestic animals, wild animals, nonhuman primates, and humans. Follicle culture conditions have been improved by optimizing gonadotropin levels, regulatory factors, nutrient supplements, oxygen concentration, and culture matrices. This review summarizes quality assessment of oocytes generated from in vitro-developed antral follicles from the preantral stage, including oocyte epigenetic and genetic profile, cytoplasmic and nuclear maturation, preimplantation embryonic development following in vitro fertilization, as well as pregnancy and live offspring after embryo transfer. The limitations of oocyte quality evaluation following IVFD and the gaps in our knowledge of IVFD to support proper oocyte development are also discussed. The information may advance our understanding of the requirements for IVFD, with a goal of producing competent oocytes with genetic integrity to sustain embryonic development resulting in healthy offspring.<\/jats:p>","DOI":"10.1093\/biolre\/ioab242","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T15:56:32Z","timestamp":1640706992000},"page":"291-315","source":"Crossref","is-referenced-by-count":22,"title":["Oocyte quality following in vitro follicle development"],"prefix":"10.1093","volume":"106","author":[{"given":"Jing","family":"Xu","sequence":"first","affiliation":[{"name":"Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary B","family":"Zelinski","sequence":"additional","affiliation":[{"name":"Division of Reproductive & Developmental Sciences, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, OR, USA"},{"name":"Department of Obstetrics and Gynecology, School of Medicine, Oregon Health & Science University, Portland, OR, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"2022041217273846500_ref1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/978-1-4614-8214-7_5","article-title":"Primate follicular development and oocyte maturation in vitro","volume":"761","author":"Xu","year":"2013","journal-title":"Adv Exp Med Biol"},{"key":"2022041217273846500_ref2","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/humupd\/8.3.243","article-title":"Follicle culture in reproductive toxicology: a tool for in-vitro testing of ovarian 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