{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:12:10Z","timestamp":1783487530544,"version":"3.55.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,29]],"date-time":"2022-01-29T00:00:00Z","timestamp":1643414400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Agriculture and Food Research Initiative Competitive","award":["2016-67015-24958"],"award-info":[{"award-number":["2016-67015-24958"]}]},{"DOI":"10.13039\/100005825","name":"USDA National Institute of Food and Agriculture","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Progesterone (P4) and interferon tau (IFNT) are important for establishment and maintenance of pregnancy in ruminants. Agmatine and polyamines (putrescine, spermidine, and spermine) have important roles in the survival, growth, and development of mammalian conceptuses. This study tested the hypothesis that P4 and\/or IFNT stimulate the expression of genes and proteins involved in the metabolism and transport of polyamines in the ovine endometrium. Rambouillet ewes (n\u2009=\u200924) were surgically fitted with intrauterine catheters on Day 7 of the estrous cycle. They received daily intramuscular injections of 50\u00a0mg P4 in corn oil vehicle and\/or 75-mg progesterone receptor antagonist (RU486) in corn oil vehicle from Days 8\u201315, and twice daily intrauterine injections (25\u00a0\u03bcg\/uterine horn\/day) of either control serum proteins (CX) or IFNT from Days 11\u201315, resulting in four treatment groups: (i) P4\u2009+\u2009CX; (ii) P4\u2009+\u2009IFNT; (iii) RU486\u2009+\u2009P4\u2009+\u2009CX; or (iv) RU486\u2009+\u2009P4\u2009+\u2009IFNT. On Day 16, ewes were hysterectomized. The total amounts of arginine, citrulline, ornithine, agmatine, and putrescine in uterine flushings were affected (P\u2009&amp;lt;\u20090.05) by P4 and\/or IFNT. P4 increased endometrial expression of SLC22A2 (P\u2009&amp;lt;\u20090.01) and SLC22A3 (P\u2009&amp;lt;\u20090.05) mRNAs. IFNT affected endometrial expression of MAT2B (P\u2009&amp;lt;\u20090.001), SAT1 (P\u2009&amp;lt;\u20090.01), and SMOX (P\u2009&amp;lt;\u20090.05) mRNAs, independent of P4. IFNT increased the abundance of SRM protein in uterine luminal (LE), superficial glandular (sGE), and glandular epithelia (GE), as well as MAT2B protein in uterine LE and sGE. These results indicate that P4 and IFNT act synergistically to regulate the expression of key genes required for cell-specific metabolism and transport of polyamines in the ovine endometrium during the peri-implantation period of pregnancy.<\/jats:p>","DOI":"10.1093\/biolre\/ioac022","type":"journal-article","created":{"date-parts":[[2022,1,31]],"date-time":"2022-01-31T01:13:55Z","timestamp":1643591635000},"page":"865-878","source":"Crossref","is-referenced-by-count":11,"title":["Progesterone and interferon tau regulate expression of polyamine enzymes during the ovine peri-implantation period"],"prefix":"10.1093","volume":"106","author":[{"given":"Katherine M","family":"Halloran","sequence":"first","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Stenhouse","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn M","family":"Moses","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heewon","family":"Seo","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory A","family":"Johnson","sequence":"additional","affiliation":[{"name":"Department of Veterinary Integrative Biosciences, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuller W","family":"Bazer","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Texas A&M University, College Station, TX, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,1,29]]},"reference":[{"key":"2022051716193326600_ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.2527\/jas1945.4134","article-title":"The necessity of the corpus luteum for maintenance of pregnancy in the ewe","volume":"4","author":"Casida","year":"1945","journal-title":"J Anim Sci"},{"key":"2022051716193326600_ref2","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1095\/biolreprod40.2.425","article-title":"Changes in ovine conceptus and endometrial function following asynchronus embryo transfer or administration of progesterone","volume":"40","author":"Ashworth","year":"1989","journal-title":"Biol Reprod"},{"key":"2022051716193326600_ref3","doi-asserted-by":"crossref","DOI":"10.21451\/1984-3143-AR2018-0014","article-title":"Cellular events during ovine implantation and impact for gestation","volume":"15","author":"Johnson","year":"2018","journal-title":"Anim Reprod"},{"key":"2022051716193326600_ref4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00726-013-1515-z","article-title":"Impacts of arginine nutrition on embryonic and fetal development in mammals","volume":"45","author":"Wu","year":"2013","journal-title":"Amino Acids"},{"key":"2022051716193326600_ref5","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1095\/biolreprod.108.071597","article-title":"Select nutrients in the ovine uterine lumen. 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Inhibition of estradiol-mediated induction of ODC: a possible mechanism of action of antiestrogens","volume":"3","author":"Bulger","year":"1976","journal-title":"Endocr Res Commun"},{"key":"2022051716193326600_ref41","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/0039-128X(83)90124-1","article-title":"Polyamine biosynthetic decarboxylase activities following estradiol-17\u03b2 or estriol stimulation of the immature rat uterus","volume":"42","author":"Lavla","year":"1983","journal-title":"Steroids"},{"key":"2022051716193326600_ref42","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/0304-4165(71)90103-6","article-title":"Stimulation by estrogens of ornithine and S-adenosylmethionine decarboxylases in the immature rat uterus","volume":"252","author":"Kaye","year":"1971","journal-title":"Biochim Biophys Acta - Gen 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