{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:25:59Z","timestamp":1783041959208,"version":"3.54.6"},"reference-count":62,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T00:00:00Z","timestamp":1643500800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000199","name":"USDA","doi-asserted-by":"publisher","award":["2019-67015-29704"],"award-info":[{"award-number":["2019-67015-29704"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hatch Project","award":["WIS01240"],"award-info":[{"award-number":["WIS01240"]}]},{"DOI":"10.13039\/100009349","name":"Eutheria Foundation","doi-asserted-by":"publisher","award":["B2-RD-19"],"award-info":[{"award-number":["B2-RD-19"]}],"id":[{"id":"10.13039\/100009349","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009349","name":"Eutheria Foundation","doi-asserted-by":"publisher","award":["B1-RD-19"],"award-info":[{"award-number":["B1-RD-19"]}],"id":[{"id":"10.13039\/100009349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,5,17]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In heifers and mares, multiple pulses of prostaglandin F2alpha (PGF) are generally associated with complete luteal regression. Although PGF pulses occur before and during luteolysis, little is known about the role of minor PGF pulses during preluteolysis on subsequent luteal and endometrial PGF production that may initiate luteolysis. Heifers (n\u2009=\u20097\/group) and mares (n\u2009=\u20096\/group) were treated with a single minor dose of PGF (3.0 and 0.5\u00a0mg, respectively) during mid-luteal phase (12 and 10\u00a0days postovulation respectively). After treatment, a transient decrease in progesterone (P4) concentrations occurred in heifers between Hours 0 and 2 but at Hour 4 P4 was not different from pretreatment. In mares, P4 was unaltered between Hours 0 and 4. Concentrations of P4 decreased in both species by Hour 24 and complete luteolysis occurred in mares by Hour 48. Luteal and endometrial gene expression were evaluated 4\u00a0h posttreatment. In heifers, luteal mRNA abundance of PGF receptor and PGF dehydrogenase was decreased, while PTGS2, PGF transporter, and oxytocin receptor were increased. In the heifer endometrium, receptors for oxytocin, P4, and estradiol were upregulated. In mares, luteal expression of PGF receptor was decreased, while PGF transporter and oxytocin receptor were increased. The decrease in P4 between Hours 4 and 24 and changes in gene expression were consistent with upregulation of endogenous synthesis of PGF. The hypotheses were supported that a single minor PGF treatment upregulates endogenous machinery for PGF synthesis in heifers and mares stimulating endogenous PGF synthesis through distinct regulatory mechanisms in heifers and mares.<\/jats:p>","DOI":"10.1093\/biolre\/ioac025","type":"journal-article","created":{"date-parts":[[2022,1,30]],"date-time":"2022-01-30T19:02:25Z","timestamp":1643569345000},"page":"979-991","source":"Crossref","is-referenced-by-count":11,"title":["Endometrial and luteal responses to a prostaglandin F2alpha pulse: a comparison between heifers and mares"],"prefix":"10.1093","volume":"106","author":[{"given":"Rafael R","family":"Domingues","sequence":"first","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Endocrinology and Reproductive Physiology Program , University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Eutheria Foundation , Cross Plains, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O J","family":"Ginther","sequence":"additional","affiliation":[{"name":"Eutheria Foundation , Cross Plains, WI, USA"},{"name":"Department of Pathobiological Sciences , School of Veterinary Medicine, University of Wisconsin-Madison, Madison, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Gomez-Leon","sequence":"additional","affiliation":[{"name":"Department of Animal and Dairy Sciences , University of Wisconsin-Madison, Madison, WI, USA"},{"name":"Eutheria Foundation , Cross Plains, WI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thadeu","family":"Castro","sequence":"additional","affiliation":[{"name":"Eutheria Foundation , Cross Plains, WI, USA"},{"name":"Department of Veterinary Medicine , Universidade Federal Rural do Rio de Janeiro, Serop\u00e9dica, RJ, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milo 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