{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T18:30:02Z","timestamp":1790620202582,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,2]],"date-time":"2022-02-02T00:00:00Z","timestamp":1643760000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01HD106485"],"award-info":[{"award-number":["P01HD106485"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD102170"],"award-info":[{"award-number":["R01HD102170"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HD101243"],"award-info":[{"award-number":["R01HD101243"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F31HD101207"],"award-info":[{"award-number":["F31HD101207"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HD087166"],"award-info":[{"award-number":["T32HD087166"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sirtuin 1 (SIRT1) is a member of the sirtuin family that functions to deacetylate both histones and non-histone proteins. Previous studies have identified significant SIRT1 upregulation in eutopic endometrium from infertile women with endometriosis. However, SIRT1 function in the uterus has not been directly studied. Using immunochemistry analysis, we found SIRT1 to be most strongly expressed at GD4.5 and GD5.5 in decidualized cells and at GD7.5 in secondary decidual cells in mouse. To assess the role of SIRT1 in uterine function, we generated uterine Sirt1 conditional knockout mice (Pgrcre\/+Sirt1f\/f; Sirt1d\/d). A 6-month fertility trial revealed that Sirt1d\/d females were subfertile. Implantation site numbers were significantly decreased in Sirt1d\/d mice compared with controls at GD5.5. Sirt1d\/d implantation sites at GD4.5 could be divided into two groups, Group #1 with luminal closure and nonspecific COX2 expression compared with controls (14\/20) and Group #2 with an open lumen and no COX2 (6\/20). In Sirt1d\/d Group #1, nuclear FOXO1 expression in luminal epithelial cells was significantly decreased. In Sirt1d\/d Group #2, nuclear FOXO1 expression was almost completely absent, and there was strong PGR expression in epithelial cells. At GD5.5, stromal PGR and COX2 were significantly decreased in Sirt1d\/d uterine in the areas surrounding the embryo compared with controls, indicating defective decidualization. An artificially induced decidualization test revealed that Sirt1d\/d females showed defects in decidualization response. All together, these data suggest that SIRT1 is important for decidualization and contributes to preparing a receptive endometrium for successful implantation.<\/jats:p>","DOI":"10.1093\/biolre\/ioac026","type":"journal-article","created":{"date-parts":[[2022,2,8]],"date-time":"2022-02-08T20:33:16Z","timestamp":1644352396000},"page":"1072-1082","source":"Crossref","is-referenced-by-count":23,"title":["SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy"],"prefix":"10.1093","volume":"106","author":[{"given":"Yeon Jeong","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Michigan State University , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Division of Developmental Biology and Physiology , Department of Biotechnology, Institute of Basic Sciences, , Seoul, South Korea"},{"name":"Sungshin Women\u2019s University , Department of Biotechnology, Institute of Basic Sciences, , Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gi-Jun","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Michigan State University , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Marquardt","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Michigan State University , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Cell and Molecular Biology Program , College of Natural Science, , East Lansing, MI, USA"},{"name":"Michigan State University , College of Natural Science, , East Lansing, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven L","family":"Young","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Division of Reproductive Endocrinology and Infertility, , Chapel Hill, NC, USA"},{"name":"University of North Carolina , Division of Reproductive Endocrinology and Infertility, , Chapel Hill, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce A","family":"Lessey","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology , Division of Reproductive Endocrinology and Infertilithy, , Winston-Salem, NC, USA"},{"name":"Atrium Health, Wake Forest Baptist , Division of Reproductive Endocrinology and Infertilithy, , Winston-Salem, NC, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae Hoon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Michigan State University , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong-Pil","family":"Cheon","sequence":"additional","affiliation":[{"name":"Division of Developmental Biology and Physiology , Department of Biotechnology, Institute of Basic Sciences, , Seoul, South Korea"},{"name":"Sungshin Women\u2019s University , Department of Biotechnology, Institute of Basic Sciences, , Seoul, South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Wook","family":"Jeong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"},{"name":"Michigan State University , Gynecology and Reproductive Biology, , Grand Rapids, MI, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,2]]},"reference":[{"key":"2022061509221191600_ref1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1006\/dbio.2000.9767","article-title":"Embryo implantation","volume":"223","author":"Carson","year":"2000","journal-title":"Dev Biol"},{"key":"2022061509221191600_ref2","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin Reprod Med"},{"key":"2022061509221191600_ref3","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0020","article-title":"Molecular cues to implantation","volume":"25","author":"Dey","year":"2004","journal-title":"Endocr Rev"},{"key":"2022061509221191600_ref4","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1038\/ni.3131","article-title":"Immune mechanisms at 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