{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:01:27Z","timestamp":1791252087067,"version":"4.1.0"},"reference-count":63,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T00:00:00Z","timestamp":1644796800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG2016-00072-FHS"],"award-info":[{"award-number":["MYRG2016-00072-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG2017-00157-FHS"],"award-info":[{"award-number":["MYRG2017-00157-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["MYRG2019-00123-FHS"],"award-info":[{"award-number":["MYRG2019-00123-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004733","name":"University of Macau","doi-asserted-by":"publisher","award":["CPG2020-00005-FHS"],"award-info":[{"award-number":["CPG2020-00005-FHS"]}],"id":[{"id":"10.13039\/501100004733","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Macau Fund for Development of Science and Technology","award":["FDCT173\/2017\/A3"],"award-info":[{"award-number":["FDCT173\/2017\/A3"]}]},{"name":"Macau Fund for Development of Science and Technology","award":["FDCT0132\/2019\/A3"],"award-info":[{"award-number":["FDCT0132\/2019\/A3"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>As a species without master sex-determining genes, zebrafish displays high plasticity in sex differentiation, making it an excellent model for studying the regulatory mechanisms underlying gonadal differentiation and gametogenesis. Despite being a gonochorist, zebrafish is a juvenile hermaphrodite that undergoes a special phase of juvenile ovary before further differentiation into functional testis and ovary. The mechanisms underlying juvenile ovary formation and subsequent gonadal differentiation remain largely unknown. In this study, we explored the role of Nobox\/nobox (new born ovary homeobox protein), another oocyte-specific transcription factor in females, in early zebrafish gonadogenesis using CRISPR\/Cas9 technology. As in mammals, nobox is specifically expressed in zebrafish gonads with a dimorphic pattern at juvenile stage. In contrast to the mutant of figla (factor in the germline alpha, another oocyte-specific transcription factor), the nobox mutants showed formation of typical perinucleolar (PN) follicles at primary growth (PG) stage in juvenile gonads, suggesting occurrence of follicle assembly from cystic oocytes (chromatin nucleolar stage, CN). These follicles, however, failed to develop further to form functional ovaries, resulting in all-male phenotype. Despite its expression in adult testis, the loss of nobox did not seem to affect testis development, spermatogenesis and male spawning. In summary, our results indicate an important role for Nobox in zebrafish ovarian differentiation and early folliculogenesis.<\/jats:p>","DOI":"10.1093\/biolre\/ioac036","type":"journal-article","created":{"date-parts":[[2022,2,14]],"date-time":"2022-02-14T13:33:51Z","timestamp":1644845631000},"page":"1254-1266","source":"Crossref","is-referenced-by-count":27,"title":["Loss of Nobox prevents ovarian differentiation from juvenile ovaries in zebrafish"],"prefix":"10.1093","volume":"106","author":[{"given":"Mingming","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Biomedical Sciences and Centre of Reproduction , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"University of Macau , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingping","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Centre of Reproduction , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"University of Macau , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"Institute of Hydrobiology , , Hangzhou 310021, China"},{"name":"Zhejiang Academy of Agricultural Sciences , , Hangzhou 310021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Centre of Reproduction , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"University of Macau , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"State Key Laboratory for Biocontrol , Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, , Guangzhou 510275, China"},{"name":"Sun Yat-sen University , Guangdong Provincial Key Laboratory of Marine Resources and Coastal Engineering, School of Marine Sciences, , Guangzhou 510275, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Toxicology and Hygienic Chemistry , School of Public Health, , Beijing 100069, China"},{"name":"Capital Medical University , School of Public Health, , Beijing 100069, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Ge","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences and Centre of Reproduction , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"},{"name":"University of Macau , Development and Aging (CRDA), Faculty of Health Sciences, , Taipa, Macau 999078, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,2,14]]},"reference":[{"key":"2022061509222120500_ref1","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature751","article-title":"DMY is a Y-specific DM-domain gene required for male development in the medaka fish","volume":"417","author":"Matsuda","year":"2002","journal-title":"Nature"},{"key":"2022061509222120500_ref2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1534\/genetics.111.137497","article-title":"Tracing the emergence of a novel sex-determining gene in medaka, Oryzias luzonensis","volume":"191","author":"Myosho","year":"2012","journal-title":"Genetics"},{"key":"2022061509222120500_ref3","doi-asserted-by":"crossref","first-page":"e1005678","DOI":"10.1371\/journal.pgen.1005678","article-title":"A tandem duplicate of anti-M\u00fcllerian hormone with a missense SNP on the Y chromosome is essential for male sex determination in Nile 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