{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T21:24:02Z","timestamp":1768253042772,"version":"3.49.0"},"reference-count":40,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,2,21]],"date-time":"2022-02-21T00:00:00Z","timestamp":1645401600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81070492"],"award-info":[{"award-number":["81070492"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81871165"],"award-info":[{"award-number":["81871165"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31872846"],"award-info":[{"award-number":["31872846"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81971387"],"award-info":[{"award-number":["81971387"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071646"],"award-info":[{"award-number":["82071646"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81801530"],"award-info":[{"award-number":["81801530"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2018YFC1004400"],"award-info":[{"award-number":["2018YFC1004400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["82030040"],"award-info":[{"award-number":["82030040"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Endometrial receptivity damage caused by impaired decidualization may be one of the mechanisms of infertility in endometriosis (EMs). Our previous study demonstrated that Calpain-7 (CAPN7) is abnormally overexpressed in EMs. Whether CAPN7 affects the regulation of decidualization and by what mechanism CAPN7 regulates decidualization remains to be determined. In this study, we found CAPN7 expression decreased during human endometrial stromal cell (HESC) decidualization in vitro. CAPN7 negatively regulated decidualization in vitro and in vivo. We also identified one conserved potential PEST sequence in the AKT1 protein and found that CAPN7 was able to hydrolyse AKT1 and enhance AKT1\u2019s phosphorylation. Correspondingly, CAPN7 notably promoted the phosphorylation of Forkhead Box O1 (FoxO1), the downstream of AKT1 protein, at Ser319, leading to increased FoxO1 exclusion from nuclei and attenuated FoxO1 transcriptional activity in decidualized HESC. In addition, we detected endometrium CAPN7, p-AKT1, and p-FoxO1 expressions were increased in EMs. These data demonstrate that CAPN7 negatively regulates HESC decidualization in EMs probably by promoting FoxO1\u2019s phosphorylation and FoxO1 nuclear exclusion via hydrolyzing AKT1. The dysregulation of CAPN7 may be a novel cause of EMs.<\/jats:p>","DOI":"10.1093\/biolre\/ioac041","type":"journal-article","created":{"date-parts":[[2022,2,22]],"date-time":"2022-02-22T11:59:56Z","timestamp":1645531196000},"page":"1112-1125","source":"Crossref","is-referenced-by-count":11,"title":["Calpain7 negatively regulates human endometrial stromal cell decidualization in EMs by promoting FoxO1 nuclear exclusion via hydrolyzing AKT1"],"prefix":"10.1093","volume":"106","author":[{"given":"Nannan","family":"Kang","sequence":"first","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huizhi","family":"Shan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxia","family":"Wang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Mei","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"Jiang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jidong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chenyang","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhen","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guijun","family":"Yan","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixiang","family":"Sun","sequence":"additional","affiliation":[{"name":"Center for Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Affiliated Drum Tower Hospital of Nanjing University Medical School , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Center for Molecular Reproductive Medicine , , Nanjing 210008, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210008, People\u2019s Republic of China"},{"name":"State Key Laboratory of Pharmaceutical Biotechnology , , Nanjing 210032, People\u2019s Republic of China"},{"name":"Nanjing University , , Nanjing 210032, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"2022061509220778700_ref1","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(10)60490-4","article-title":"Endometriosis and infertility: pathophysiology and management","volume":"376","author":"Ziegler","year":"2010","journal-title":"Lancet"},{"key":"2022061509220778700_ref2","doi-asserted-by":"crossref","first-page":"E433","DOI":"10.1210\/jc.2014-3720","article-title":"Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization","volume":"100","author":"Su","year":"2015","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061509220778700_ref3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1093\/molehr\/gan073","article-title":"The IGF system in in-vitro human decidualization","volume":"15","author":"Ganeff","year":"2009","journal-title":"Mol Hum Reprod"},{"key":"2022061509220778700_ref4","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1055\/s-0029-1242989","article-title":"Endometrial decidualization: of mice and men","volume":"28","author":"Ramathal","year":"2010","journal-title":"Semin Reprod Med"},{"key":"2022061509220778700_ref5","doi-asserted-by":"crossref","first-page":"3870","DOI":"10.1210\/en.2006-0167","article-title":"FOXO1A differentially regulates genes of decidualization","volume":"147","author":"Buzzio","year":"2006","journal-title":"Endocrinology"},{"key":"2022061509220778700_ref6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171004","article-title":"Dysregulation of in vitro decidualization of human endometrial stromal cells by insulin via transcriptional inhibition of Forkhead box protein O1","volume":"12","author":"Ujvari","year":"2017","journal-title":"PLoS One"},{"key":"2022061509220778700_ref7","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1210\/me.2014-1292","article-title":"FOXO1 is required for binding of PR on IRF4, novel transcriptional regulator of endometrial stromal decidualization","volume":"29","author":"Vasquez","year":"2015","journal-title":"Mol Endocrinol"},{"key":"2022061509220778700_ref8","doi-asserted-by":"crossref","first-page":"E35","DOI":"10.1210\/jc.2011-1527","article-title":"Increased activation of the PI3K\/AKT pathway compromises decidualization of stromal cells from endometriosis","volume":"97","author":"Yin","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"key":"2022061509220778700_ref9","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/1477-7827-11-64","article-title":"CAPN 7 promotes the migration and invasion of human endometrial stromal cell by regulating matrix metalloproteinase 2 activity","volume":"11","author":"Liu","year":"2013","journal-title":"Reprod Biol Endocrinol"},{"key":"2022061509220778700_ref10","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1152\/physrev.00029.2002","article-title":"The calpain system","volume":"83","author":"Goll","year":"2003","journal-title":"Physiol Rev"},{"key":"2022061509220778700_ref11","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S0968-0004(96)10031-1","article-title":"PEST sequences and regulation by proteolysis","volume":"21","author":"Rechsteiner","year":"1996","journal-title":"Trends Biochem Sci"},{"key":"2022061509220778700_ref12","doi-asserted-by":"crossref","first-page":"37368","DOI":"10.1074\/jbc.M307161200","article-title":"Phosphorylation of a pest sequence in ABCA1 promotes calpain degradation and is reversed by ApoA-I","volume":"278","author":"Martinez","year":"2003","journal-title":"J Biol Chem"},{"key":"2022061509220778700_ref13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s12958-015-0079-z","article-title":"Kr\u00fcppel-like factor 12 is a novel negative regulator of forkhead box O1 expression: a potential role in impaired decidualization","volume":"13","author":"Zhang","year":"2015","journal-title":"Reprod Biol Endocrinol"},{"key":"2022061509220778700_ref14","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1210\/en.2012-1585","article-title":"WNT4 acts downstream of BMP2 and functions via \u03b2-catenin signaling pathway to regulate human endometrial stromal cell differentiation","volume":"154","author":"Li","year":"2013","journal-title":"Endocrinology"},{"key":"2022061509220778700_ref15","doi-asserted-by":"crossref","first-page":"31725","DOI":"10.1074\/jbc.M704723200","article-title":"Bone morphogenetic protein 2 functions via a conserved signaling pathway involving Wnt4 to regulate uterine decidualization in the mouse and the human","volume":"282","author":"Li","year":"2007","journal-title":"J Biol Chem"},{"key":"2022061509220778700_ref16","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1111\/jog.12392","article-title":"Regulation of decidualization and angiogenesis in the human endometrium: mini review","volume":"40","author":"Okada","year":"2014","journal-title":"J Obstet Gynaecol Res"},{"key":"2022061509220778700_ref17","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1042\/bj3490629","article-title":"Identification of the differential distribution patterns of mRNAs and consensus binding sequences for mouse DAF-16 homologues","volume":"349","author":"Furuyama","year":"2000","journal-title":"Biochem J"},{"key":"2022061509220778700_ref18","doi-asserted-by":"crossref","first-page":"5289","DOI":"10.1074\/jbc.M110.163667","article-title":"FoxO1 mediates an autofeedback loop regulating SIRT1 expression","volume":"286","author":"Xiong","year":"2011","journal-title":"J Biol Chem"},{"key":"2022061509220778700_ref19","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/jpi.12295","article-title":"Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C\/EBP\u03b2 and NF\u03baB cleavage","volume":"60","author":"Wu","year":"2016","journal-title":"J Pineal Res"},{"key":"2022061509220778700_ref20","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1111\/jnc.12956","article-title":"E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity","volume":"132","author":"Zyskind","year":"2015","journal-title":"J Neurochem"},{"key":"2022061509220778700_ref21","doi-asserted-by":"crossref","first-page":"13106","DOI":"10.1074\/jbc.RA119.008649","article-title":"AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins","volume":"294","author":"Saline","year":"2019","journal-title":"J Biol Chem"},{"key":"2022061509220778700_ref22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.apsb.2015.08.001","article-title":"Cysteine proteases as therapeutic targets: does selectivity matter? A systematic review of calpain and cathepsin inhibitors","volume":"5","author":"Siklos","year":"2015","journal-title":"Acta Pharm Sin B"},{"key":"2022061509220778700_ref23","doi-asserted-by":"crossref","first-page":"L145","DOI":"10.1152\/ajplung.00348.2015","article-title":"Activation of calpain by renin-angiotensin system in pleural mesothelial cells mediates tuberculous pleural fibrosis","volume":"311","author":"Yang","year":"2016","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"2022061509220778700_ref24","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1600-0897.2007.00576.x","article-title":"Role of mu-calpain in human decidua for recurrent miscarriage","volume":"59","author":"Kumagai","year":"2008","journal-title":"Am J Reprod Immunol"},{"key":"2022061509220778700_ref25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1007\/s00418-013-1165-y","article-title":"Calpain 2 activity increases at the time of implantation in rat uterine luminal epithelial cells and administration of calpain inhibitor significantly reduces implantation sites","volume":"141","author":"Kaneko","year":"2014","journal-title":"Histochem Cell Biol"},{"key":"2022061509220778700_ref26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/s41419-018-0317-3","article-title":"Calpain7 impairs embryo implantation by downregulating \u03b23-integrin expression via degradation of HOXA10","volume":"9","author":"Yan","year":"2018","journal-title":"Cell Death Dis"},{"key":"2022061509220778700_ref27","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.rbmo.2009.10.001","article-title":"Differential regulation of Akt phosphorylation in endometriosis","volume":"19","author":"Cinar","year":"2009","journal-title":"Reprod Biomed Online"},{"key":"2022061509220778700_ref28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/biolre\/iox152","article-title":"Pharmacological blockage of the CXCR4-CXCL12 axis in endometriosis leads to contrasting effects in proliferation, migration, and invasion","volume":"98","author":"Ruiz","year":"2018","journal-title":"Biol Reprod"},{"key":"2022061509220778700_ref29","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1080\/09513590.2019.1680627","article-title":"PI3K\/AKT pathway is altered in the endometriosis patient's endometrium and presents differences according to severity stage","volume":"36","author":"Madanes","year":"2020","journal-title":"Gynecol Endocrinol"},{"key":"2022061509220778700_ref30","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1095\/biolreprod.102.009316","article-title":"Regulation of insulin-like growth factor binding protein-1 promoter activity by FKHR and HOXA10 in primate endometrial cells","volume":"68","author":"Kim","year":"2003","journal-title":"Biol Reprod"},{"key":"2022061509220778700_ref31","doi-asserted-by":"crossref","first-page":"20825","DOI":"10.1074\/jbc.M201018200","article-title":"Cyclic AMP-induced forkhead transcription factor, FKHR, cooperates with CCAAT\/enhancer-binding protein beta in differentiating human endometrial stromal cells","volume":"277","author":"Christian","year":"2002","journal-title":"J Biol Chem"},{"key":"2022061509220778700_ref32","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20153822","article-title":"Progesterone and estrogen signaling in the endometrium: what goes wrong in endometriosis?","volume":"20","author":"Marquardt","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2022061509220778700_ref33","doi-asserted-by":"crossref","DOI":"10.1093\/biolre\/ioab182","article-title":"Attenuated monoamine oxidase a impairs endometrial receptivity in women with adenomyosis via downregulation of FOXO1","volume":"105","author":"Tian","year":"2021","journal-title":"Biol Reprod"},{"key":"2022061509220778700_ref34","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1073\/pnas.0502738102","article-title":"Acetylation of Foxo1 alters its DNA-binding ability and sensitivity to phosphorylation","volume":"102","author":"Matsuzaki","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022061509220778700_ref35","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1073\/pnas.0406789102","article-title":"Skp2 inhibits FOXO1 in tumor suppression through ubiquitin-mediated degradation","volume":"102","author":"Huang","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"2022061509220778700_ref36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/10799890903517947","article-title":"PCAF represses transactivation function of FOXO1 in an acetyltransferase-independent manner","volume":"30","author":"Yoshimochi","year":"2010","journal-title":"J Recept Signal Transduct Res"},{"key":"2022061509220778700_ref37","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/S0014-5793(02)03846-2","article-title":"Estrogen regulation of Pak1 and FKHR pathways in breast cancer cells","volume":"535","author":"Mazumdar","year":"2003","journal-title":"FEBS Lett"},{"key":"2022061509220778700_ref38","doi-asserted-by":"crossref","first-page":"2819","DOI":"10.1007\/s00125-015-3744-z","article-title":"Protein kinase C\u03b4 regulates nuclear export of FOXO1 through phosphorylation of the chaperone 14-3-3\u03b6","volume":"58","author":"Gerst","year":"2015","journal-title":"Diabetologia"},{"key":"2022061509220778700_ref39","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.bbrc.2010.12.027","article-title":"The orphan nuclear receptor Nur77 regulates decidual prolactin expression in human endometrial stromal cells","volume":"404","author":"Jiang","year":"2011","journal-title":"Biochem Biophys Res Commun"},{"key":"2022061509220778700_ref40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.ebiom.2019.10.018","article-title":"EHD1 impairs decidualization by regulating the Wnt4\/\u03b2-catenin signaling pathway in recurrent implantation failure","volume":"50","author":"Zhou","year":"2019","journal-title":"EBioMedicine"}],"container-title":["Biology of Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/biolreprod\/advance-article-pdf\/doi\/10.1093\/biolre\/ioac041\/43110246\/ioac041.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/106\/6\/1112\/44029515\/ioac041.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/biolreprod\/article-pdf\/106\/6\/1112\/44029515\/ioac041.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T09:23:44Z","timestamp":1655285024000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/biolreprod\/article\/106\/6\/1112\/6533538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2,21]]},"references-count":40,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,2,21]]},"published-print":{"date-parts":[[2022,6,13]]}},"URL":"https:\/\/doi.org\/10.1093\/biolre\/ioac041","relation":{},"ISSN":["0006-3363","1529-7268"],"issn-type":[{"value":"0006-3363","type":"print"},{"value":"1529-7268","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6]]},"published":{"date-parts":[[2022,2,21]]}}}